Hi everyone!
For the past few weeks i've been reading nonstop trying to figure this one out, but can't seem to resolve this "enigma".
I was diagnosed during the years with OCD (not sure i fit this one), CFS (not really tired just very achy), and suffer from constant 24\7 tension feeling in my stomach.
Anyway let me get to the main point here which is that when taking Dimenhydrinate (a muscarinic acetylcholine antagonist), it seem to alleviate this constant wired\anxiety felling and some of the stomach tension i've had for the past 10 years.
Now my two main issues with Dimenhydrinate are; one- after taking a very low dose (25MG twice or thrice a day) i've woken up in the middle of the night with some sort of seizure feeling (electricity feeling in the brain for a few seconds, repeating every time i start falling asleep), which led me to think it might triggerd ADNFLE (Autosomal dominant nocturnal frontal lobe epilepsy), and two - Dimenhydrinate antagonise all muscarinic acetylcholine receptors, and it's probably only a part of the med's mechanism which give's me the positive symptoms relief im getting from it.
Just to inform you, i have taken dozens of different meds through the years, including SSRI's (most of them), antipsychotics (risperidal, sulpiride), antiepileptics (lamictal, tegretol...) and almost every supplement you can probably think of, and non of them felt like it "touched" the core problem like Dimenhydrinate does. actually, what led me to try Dimenhydrinate for the first place was noticing how much worse i'm feeling after taking the pro cholinergics- lecithin and pramiracetam.
So what do you guys think? what part of the med's action is the one that makes me feel better?
My main "suspect" at the moment is the M3 receptor, as according to what i was reading, it is very widespread in the gut, and the brain.
I know it's a very complicated issue, but i will greatly appreciate any insight any of you might have.
Thank you.
Edited by Cosma, 04 January 2014 - 05:56 AM.