6 replies to this topic

[STOPOT]

Hey. I've been reading about the dosing for phenibut and picamilon and something seems odd. Phenibut's dosage is about 750mg a dose but Picamilon is about 70mg a dose. My question is, why such a big difference in dosage. Isn't Picamilon just a GABA with a niacin attached and Phenibut is just a GABA with a phenyl group attached? So why does it take less Picamilon to get the anxiolytic effect?

[branks]

Phenibut is effective at doses as low as 150mg in certain individuals. It has alot to do with persoanl biochemistry to be honest.

[lammas2]

Biochemistry isn't as simple as niacin group vs phenyl group.

You also need to take into account:
- bioavailability: how much of the substance gets absorbed in the GI tract;
- XlogP3 value: how readily does the substance cross the blood-brain barrier;
- which receptor(s) does the substance bind to;
- what is the binding affinity of the substance;
- half-life of the substance, at what rate is the drug metabolised.

[STOPOT]

Once broken down and inside the BBB both substances have the same GABA neurotransmitter, so wouldn't half-life, metabolism, oral bioavailability, and binding receptors be the same? I'm just interested in the GABA part, I know that niacin and the phenyl group act differently once they are broken apart from GABA.

[STOPOT]

Ok I found out more.
Phenibut is a GABAB receptor ligands antagonist
Picamilon is GABA itself.
So they indeed do different things inside the body.
The question now is, can I take both a the same time to get more of an anxiolytic effect?

[branks]

You totally can, I don't think it would have any serious toxic reactions at normal doses. There might be some sedation. You may be asking for a very long nap combining the two, or you might not even notice a difference at all.

[protoject]

Picamilon is a joke to me. Is there really any evidence that it actually crosses the BBB and then drops off the Gaba molecule into the receptor sites? I don't know, but I know I felt practically nothing from it. Looks like I'm an InternationalAntiAgingSystems propaganda victim for buying it. (though I applaud anyone who has had success with it!0

And phenibut is a gaba-b agonist. If it were an antagonist you'd probably have a seizure.