11 replies to this topic

[velocidex]

Does anyone have any information about the safety of combining Huperzine A and selegiline? I'm concerned that one is a MAO inhbitor and the other an AChE inhibitor. If huperzine is metabolised through MAO, you could get quite substantial increases in huperzine A.... massive excesses of acetylcholine = very not good.

[LifeMirage]

Zero interaction.

[mnosal]

I've been on 1mg 2x day Selepryl and 180mcg Hup-A for 3 months now and can only say good things both. Not sure about MOA and breakdown of Huperzine, I thought that Acetylcholinesterase would eventually just overtake the amount of Huperzine in the system and begin its normal Ach breakdown.

If you are concerned, limit your supplementation of Choline/Alpha-GPC. I find that I need only 300-400mg of A-GPC to feel "balanced" while using the Huperzine,
and that's with 4g/day of Piracetam as well.

[velocidex]

Can you make an equivalent choline dosage recommendation? I realise that choline is inferior, but that's all I've got access to atm...

Just for the record, I'm currently taking 4g choline, 4g piracetam, 1g l-phenylalanine, 5mg selegiline, 1000mg DMAE daily.

[mnosal]

I'm not sure on a ratio for Choline to A-GPC, anyone have any suggestions?

I guess you could add the Hup-A @ 50mcg 2x day and lower the Choline by 1 gram, then wait a few days to judge if you're depleted or overstimulated.

In theory the Hup-A should allow you to significantly decrease Choline intake.

[helza]

If your choline is depleted of overstimulated what would it feel like? Need to know what signs to watch for when i take it

[mnosal]

Over stimulation is hard to describe, sorta like too much traffic in your head. Thoughts come faster than the ability to focus, I become sloppy when putting thoughts to paper or computer(jumbled typing or easy spelling errors i.e. "aer" instead or "are")

Depleted for me is manifested by slight headache and inability to focus. Reading speed falls off quickly and concentration suffers.

These may be universal or singular only to me, so I'd advise getting 2nd,3rd & 4th opinions on this. Niether is life threatening but could hurt academic/work performance

[velocidex]

True acetylcholine excess is a real problem. Nerve gases like sarin and VX work as cholinesterase inhibitors, causing your body to go into choline overload.

[jeromewilson]

Cool, does anyone know which offshore pharmacies sell Sarin? Do you think it might interfere with anything in my stack:

Scopolamine 500mg
Tabun 15mg
Agent Orange 750mg

Hold on, back in a minute - there's someone at the door...

[mnosal]

Yeah I did some scopolamine with the bad kids behind the library once...I couldn't remember where my house was for like three days

[enemy]

Incidentally, low dose scopolamine is an excellent motion-sickness preventive.