9 replies to this topic

[the_apollo]

Recently i've found that Inositol may be 'able to reverse desensitization of serotonin receptors', ( http://www.ncbi.nlm..../pubmed/9169302)

I am currently on citalopram (an SSRI) for anxiety,

and came to think about if Inositol may have restorative properties at the serotonin 5HT1A autoreceptor and 5HT2C receptor (those two are what i worry about the most),
i mean; if Inositol does in fact reverse densensitization on those receptor types, that would pretty much reverse a good deal of the SSRI anti-depressive properties..

So as my question is; Does Inositol reverse desensitization of the 5HT1A autoreceptor and the 5HT2C receptor? (and would it reverse SSRI-induced changes to them?)

[lammas2]

Several double-blind placebo-controlled studies have shown significant weight loss in patients treated with myo-inositol, a precursor to a number of second messengers including inositol triphosphate (IP3). IP3 is an intracellular second messenger molecule that acts downstream from the 5-HT2C receptor. Supplementation with myo-inositol may thus circumvent the 5-HT2C receptor blockade and combat the weight gain and associated metabolic disturbances commonly observed with atypical antipsychotics.

http://www.genomind....mple-Report.pdf

[mrd1]

The 5-ht2c receptor down regulates from both agonism and antagonism. Therefore, even if you ignored autoreceptors, still it should possibly downregulate even more when exposed to both an agonist and antagonist

An example of this paradoxical event is already intergrated into medicine (although many doctors don't seem to understand it, in my experiance) where atypical antipsychotics, despite antagonizing the 5-ht2c receptor results in more down regulation then with just a ssri alone. This is also why an atypical antipsychotic + an ssri can starting working in 2-3 weeks vs ssris as a monotherapy taking 6-8 weeks. This is documented very well to the point where it is fda approved in people who don't fully respond to ssri monotherapy.

[nowayout]

Well, nobody knows how SSRIs work, but there is a hypothesis that they may work precisely by desensitizing certain 5HT receptors. This may be one reason why they don't work right away.

[the_apollo]

Well, nobody knows how SSRIs work, but there is a hypothesis that they may work precisely by desensitizing certain 5HT receptors. This may be one reason why they don't work right away.

False. It is known just about how the basics of SSRI is.

Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects.

http://www.ncbi.nlm....pubmed/10333979

But you are half right there, the reason why SSRIs take time to start work is because they have a agonist-preference for the 5HT1A autoreceptor which desensitize in response to agonists (in this case SSRIs).

[nowayout]

False. It is known just about how the basics of SSRI is.

Well, the amine hypotheses for how SSRIs were thought to work against depression were pretty much known to be contradicted by experimental data already by the 80s if not earlier, and are not taken seriously by many researchers today. SSRIs continued to be marketed with a false story for how they supposedly work until the 00s in the U.S., though, when the FDA finally put a stop to that practice. The myths regarding their functioning are now so deeply embedded in the public consciousness, though, that they will probably not die in our lifetimes.

Edited by nowayout, 20 February 2014 - 05:39 PM.

[mrd1]

Well, technically a antagonism or agnoism of the 5-ht subscribbt 2a and 2c are capable of unducing downregulation capable of increase norepinephrine and dopamine release in some parts of the brain and reducing some of the overexpression of receptors in autopsied brains of people who commit suicide although correlation does not equal causation. But, at the very very least, provide neurogenesis in a albiet far from my personal opinion most ideal way.

[the_apollo]

False. It is known just about how the basics of SSRI is.

Well, the amine hypotheses for how SSRIs were thought to work against depression were pretty much known to be contradicted by experimental data already by the 80s if not earlier, and are not taken seriously by many researchers today. SSRIs continued to be marketed with a false story for how they supposedly work until the 00s in the U.S., though, when the FDA finally put a stop to that practice. The myths regarding their functioning are now so deeply embedded in the public consciousness, though, that they will probably not die in our lifetimes.

Is that a real fact or just your take on SSRIs?
Since there are research and tests being done on SSRIs that support their original serotonin function, but no "fact" as to them being something else.

[nowayout]

False. It is known just about how the basics of SSRI is.

Well, the amine hypotheses for how SSRIs were thought to work against depression were pretty much known to be contradicted by experimental data already by the 80s if not earlier, and are not taken seriously by many researchers today. SSRIs continued to be marketed with a false story for how they supposedly work until the 00s in the U.S., though, when the FDA finally put a stop to that practice. The myths regarding their functioning are now so deeply embedded in the public consciousness, though, that they will probably not die in our lifetimes.

Is that a real fact or just your take on SSRIs?
Since there are research and tests being done on SSRIs that support their original serotonin function, but no "fact" as to them being something else.

Well, if so then this would certainly be news to the FDA.