Synergy or more harm than good? Resveratrol + Curcumin + Black Pepper ? - Supplements

Synergy or more harm than good? Resveratro...

Poll: The Combo (4 member(s) have cast votes)

Would you combine resveratrol, quercetin, curcumin/turmeric and black pepper for synergy?

yes, but only those four (1 votes [25.00%])
Percentage of vote: 25.00%
yes and I wouldnt worry about combining these with nootropics at normal doses (2 votes [50.00%])
Percentage of vote: 50.00%
no, its unlikely to be synergistic (0 votes [0.00%])
Percentage of vote: 0.00%
no, it could be harmful (1 votes [25.00%])
Percentage of vote: 25.00%

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LexLux 20 Feb 2014

I just used my pill machine to combine my trans-reveratrol supplement from life extension (contains quercetin) with turmeric, black pepper, rhodiola, ashwagandha and creatine. Each new capsule contains a smaller dose of each supplement than what was present in their original respective capsules. So this means smaller doses with every meal and I can take advantage of the oil in food to help with absorbtion.

Why?-
There could be benefits of taking resveratrol with the curcumin since they have been observed to act synergistically in:

suppressing immune response where a faulty immune response plays a pathogenic role in a wide spectrum of inflammatory diseases and;
- http://www.ncbi.nlm....les/PMC1810449/
anti-cancer
- http://www.ncbi.nlm....pubmed/23446753
- http://www.tandfonli...62#.UwYNFc4U2W8

The black pepper should increase the bio-availability of:

resveratrol and;
- http://www.ncbi.nlm....pubmed/21714124
curcumin
- http://www.sciencedi...00689931201606X

Finally, has anyone tried heat-stabilising turmeric/curcumin (other than with cooking) to increase bioavailability? This study seems support it:

http://online.lieber...89/adt.2007.064

I was thinking of putting some in a pan and heating it in the oven until the water boils away. Thoughts?

Why is this not a good idea? -
I do question if there might be a downside considering that Resveratrol, Curcumin and Quercetin inhibit p450, could this be doing more harm than good? I dont take any persciptions, but I am not sure about the nootropics.

http://www.ncbi.nlm....pubmed/20027150

However I did find this study:

Piperine and Quercetin Enhances Antioxidant and Hepatoprotective effect of Curcumin in Paracetamol Induced Oxidative Stress:

http://web.b.ebscoho...spLJwGA==&crl=c
Any feedback would be appreciated.
Edited by LexLux, 20 February 2014 - 07:27 AM.

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