I recent found a website selling the adrafinil derivative CRL-40,941. Worth checking out. Could someone do a review at your own risk with your lab rat? Thanks.
http://www.purechemi...40941-128-c.asp
Posted 04 March 2014 - 09:59 PM
Posted 04 March 2014 - 10:04 PM
Posted 04 March 2014 - 10:11 PM
Posted 04 March 2014 - 10:26 PM
I then searched up 4-fa, and it was indeed neurotoxic... it is indeed a research chemical.(I am not a pharmacist/pharmacologist/toxicologist, but I do read about this sort of stuff in my free time. Feel free to take this post with a grain of salt.)
The jury's still out on this one due to lack of research. Basically, the flouride ion is highly [neuro]toxic, but when flourine is bound to a ring it forms one of the strongest bonds in organic chemistry, requiring a large amount of energy to break the flouride ion off. This bond is so strong that it's very unlikely that it's broken when your body metabolizes the fluorinated drug (thus releasing the toxic flouride ion), but it's certainly not impossible. Basically, there's no way to know for sure in the absence of clinical research.
To answer the second part of your question, yes, this would carry over to nootropics.
tl;dr: nobody really knows for sure.
Posted 04 March 2014 - 11:53 PM
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