• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Microbiome – health & life span

microbiome

  • Please log in to reply
223 replies to this topic
⌛⇒ MITOMOUSE has been fully funded!

#211 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 26 May 2018 - 03:12 PM

Another good read and list of references on probiotics supplementation on humans regarding the gut brain axis:

 

"...This review explores the evidence demonstrating how the gut microbiome may affect brain function in adults, thereby having an impact on
stress, anxiety, depression, and cognition. In vitro, in vivo, and human studies reporting an association between a change in the gut microbiome and functional changes in the brain are highlighted, as are studies outlining the mechanisms by which the brain affects the microbiome and the gastrointestinal tract. Possible modes of action to explain how the gut microbiome and the brain functionally affect each other are proposed. Supplemental probiotics to combat brain-related dysfunction offer a promising approach, provided future research elucidates their mode of action and possible side effects. Further studies are warranted to establish how pre- and probiotic interventions may help to balance brain function in healthy and diseased individuals...
"

 

"...Communication between the brain and the microbiota involves epithelial receptor– mediated signaling, immune modulation, and stimulation of enteric neurons by bacterial metabolites. Important for this crosstalk is the ability of the microbiota to regulate the availability of circulating tryptophan, which affects serotonin synthesis, and to alter the expression of some CNS receptors, thereby enabling them to directly influence brain excitability and function as well as to exert epigenetic control of gene expression..."

 

Mohajeri MH, La fata G, Steinert RE, Weber P. Relationship between the gut microbiome and brain function. Nutr Rev. 2018

https://www.ncbi.nlm...pubmed/29701810

 

Attached File  brain gut studies.PNG   133.09KB   0 downloads



#212 pamojja

  • Guest
  • 1,861 posts
  • 415
  • Location:Austria

Posted 26 May 2018 - 04:43 PM

For anyone not aware yet, one can upload one's ubiome result to this private site: http://microbiomepre...rewebsites.net/

which is a huge data-base (in development), which for example identifies over- or undergrowth of particular bacteria and its food, supplemental or prescription modifier found reverences for.


Edited by pamojja, 26 May 2018 - 04:44 PM.


Click HERE to rent this BIOSCIENCE adspot to support LongeCity (this will replace the google ad above).

#213 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 12 June 2018 - 05:49 PM

The following is an extremely interesting study on the longevity effect of acarbose (used to treat diabetes) mediated by the gut microbiota, even though there are obvious difficulties to translate to humans due to the vast variety of composition of microbiota between different organisms.

 

Changes in the gut microbiota and fermentation products associated with enhanced longevity in acarbose-treated mice.

“…We have demonstrated a correlation between fecal SCFAs and lifespan in mice, suggesting a role of the gut microbiota in thelongevity-enhancing properties of acarbose. Treatment modulated the taxonomic composition and fermentation products of the gut microbiome, while the site-dependence of the microbiota illustrates the challenges facing reproducibility and interpretation in microbiome studies. These results motivate future studies exploring manipulation of the gut microbial community and its fermentation products for increased longevity, and to test a causal role of SCFAs in the observed effects of acarbose…”

https://www.biorxiv....311456.full.pdf

 

I am also puzzled by the fact that it is the second time I meet a drug, typically used for diabetes, investigated for lifespan or healthspan effects We know about metformin and his modulation of the human gut microbiota, e.g. increasing the population of Akkermansia muciniphila. We know about the potential beneficial effect of metformin on healthspan (possibly on longevity?) and I just speculate about this similitude maybe due to both drugs affecting morbidity and diabetes?

 

Attached File  acarbose.PNG   28.6KB   0 downloads


  • Informative x 2

sponsored ad

  • Advert
Advertisements help to support the work of this non-profit organisation. [] To go ad-free join as a Member.

#214 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 30 July 2018 - 09:19 AM

A short small review on microbiota impact on health and longevity.

 

I found interesting the concept of functional core microbiome, the changes associated to age and dysbiosis, the emphasis on "biological age" vs. chronological age and the required homeostasis in the short fatty acid production. Also quoted are small molecules such as rapamycin and metformin.

 

Kim S, Jazwinski SM. The Gut Microbiota and Healthy Aging: A Mini-Review. Gerontology. 2018;:1-8.

 

Attached File  dysbiosis homeostasis.PNG   74.61KB   0 downloads


Edited by albedo, 30 July 2018 - 09:31 AM.


#215 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 16 November 2018 - 04:25 PM

Insightful study, trying to meet some of the authors. Comments/questions?

 

"Dietary interventions to manipulate the human gut microbiome for improved health have received increasing attention. However, their design has been limited by a lack of understanding of the quantitative impact of diet on a host's microbiota. We present a highly controlled diet perturbation experiment in a healthy, human cohort in which individual micronutrients are spiked in against a standardized background. We identify strong and predictable responses of specific microbes across participants consuming prebiotic spike-ins, at the level of both strains and functional genes, suggesting fine-scale resource partitioning in the human gut. No predictable responses to non-prebiotic micronutrients were found. Surprisingly, we did not observe decreases in day-to-day variability of the microbiota compared to a complex, varying diet, and instead found evidence of diet-induced stress and an associated loss of biodiversity. Our data offer insights into the effect of a low complexity diet on the gut microbiome, and suggest that effective personalized dietary interventions will rely on functional, strain-level characterization of a patient's microbiota."

 

Gurry T, Gibbons SM, Nguyen LTT, et al. Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort. Sci Rep. 2018;8(1):12699.

 



#216 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 03 January 2019 - 09:39 PM

I was just waiting for this to happen. Here is in my view a quite pioneering work on biological age determination using ML/AI on microbiota. The study is still at level or preprint as per today:

 

"...Our most accurate DNN regressor achieved the MAE of 3.94 years. This performance is comparable with the 1.9 MAE of the PhotoAgeClock, 2.7 of the state of art methylation aging clock, 7.8 MAE transcriptomic aging clock and 5.5 MAE of the hematological aging clock published previously. We also developed a method for microbiological feature selection and annotation..."

 

Quite fascinating is that: "...Interestingly, while it contains both beneficial (e.g. Bifidobacterium) and pathogenic (e.g. Pseudomonas aeruginosa) microbes, seno-positive or seno-negative status is not determined by the nature of host-microbe interactions (Figure 12)..."

 

Fedor Galkin, Alexander Aliper, Evgeny Putin, Igor Kuznetsov, Vadim N Gladyshev, Alex Zhavoronkov

bioRxiv 507780; doi: https://doi.org/10.1101/507780



Click HERE to rent this BIOSCIENCE adspot to support LongeCity (this will replace the google ad above).

#217 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 21 February 2019 - 09:55 PM

Interesting study including casual relationships made on humans with normal glycemic levels looking at the SCFA impact on metabolic diseases risks and finding different roles between butyrate and propionate:

 

"Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 diabetes (T2D) and obesity1. However, the causal relationships remain largely unresolved. We leveraged information from 952 normoglycemic individuals for whom genome-wide genotyping, gut metagenomic sequence and fecal short-chain fatty acid (SCFA) levels were available2, then combined this information with genome-wide-association summary statistics for 17 metabolic and anthropometric traits. Using bidirectional Mendelian randomization (MR) analyses to assess causality3, we found that the host-genetic-driven increase in gut production of the SCFA butyrate was associated with improved insulin response after an oral glucose-tolerance test (P = 9.8 × 10−5), whereas abnormalities in the production or absorption of another SCFA, propionate, were causally related to an increased risk of T2D (P = 0.004). These data provide evidence of a causal effect of the gut microbiome on metabolic traits and support the use of MR as a means to elucidate causal relationships from microbiome-wide association findings."

 

Sanna S, Van zuydam NR, Mahajan A, et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat Genet. 2019;



#218 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 04 April 2019 - 07:37 AM

A company to follow on Akkermansia muciniphila (sorry if old news to you)

University of Louvain and Wageningen University launch their new spin-off A-Mansia: a microbiome company

https://uclouvain.be...in-off-ucl.html

 



#219 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 01 May 2019 - 01:45 PM

Good review of the current thinking about the relationship between aging and the host microbiota:

https://www.leafscie...binar-released/



⌛⇒ MITOMOUSE has been fully funded!

#220 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 04 July 2019 - 11:50 AM

I am always concerned by heavy usage of computer screen for my vision. This is an encouraging research which hopefully will became replicated and actionable in the future:

Morita Y, Jounai K, Miyake M, Inaba M, Kanauchi O. Effect of Heat-Killed Lactobacillus paracasei KW3110 Ingestion on Ocular Disorders Caused by Visual Display Terminal (VDT) Loads: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study. Nutrients. 2018;10(8)

"...In conclusion, the findings of this study indicated that L. paracasei KW3110 suppressed blue light-induced retinal pigment epithelial cell death in vitro and ingestion of L. paracasei KW3110 had positive effects for improving some objective and subjective parameters of eye disorders and eye fatigue induced by VDT loads. Further studies enrolling many more subjects should be carried out to more clearly reveal the clinical effects of L. paracasei KW3110 on ocular disorder including eye fatigue..."

Not a huge surprise considering the gut/brain axis and the fact some consider eyes as a part of the brain. What do you do to protect your eyes?


Edited by albedo, 04 July 2019 - 12:31 PM.

  • Informative x 1

#221 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 04 August 2019 - 03:45 PM

Interesting results on health and life spans, on mouse models and human progeria patients, in particular about the positive role of Akkermansia muciniphila:

 

Bárcena C, Valdés-mas R, Mayoral P, et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat Med. 2019

 

The gut microbiome is emerging as a key regulator of several metabolic, immune and neuroendocrine pathways1,2. Gut microbiome deregulation has been implicated in major conditions such as obesity, type 2 diabetes, cardiovascular disease, non-alcoholic fatty acid liver disease and cancer3-6, but its precise role in aging remains to be elucidated. Here, we find that two different mouse models of progeria are characterized by intestinal dysbiosis with alterations that include an increase in the abundance of Proteobacteria and Cyanobacteria, and a decrease in the abundance of Verrucomicrobia. Consistent with these findings, we found that human progeria patients also display intestinal dysbiosis and that long-lived humans (that is, centenarians) exhibit a substantial increase in Verrucomicrobia and a reduction in Proteobacteria. Fecal microbiota transplantation from wild-type mice enhanced healthspan and lifespan in both progeroid mouse models, and transplantation with the verrucomicrobia Akkermansia muciniphila was sufficient to exert beneficial effects. Moreover, metabolomic analysis of ileal content points to the restoration of secondary bile acids as a possible mechanism for the beneficial effects of reestablishing a healthy microbiome. Our results demonstrate that correction of the accelerated aging-associated intestinal dysbiosis is beneficial, suggesting the existence of a link between aging and the gut microbiota that provides a rationale for microbiome-based interventions against age-related diseases.



#222 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 10 November 2019 - 08:29 PM

Interesting video by Dr Greger on microbiota enterotype where "There appear to be just two types of people in the world: those who have mostly Bacteroides type bacteria in their gut, and those whose colons are overwhelmingly home to Prevotella species instead."

https://nutritionfac..._eid=f56b67bcfa


  • Informative x 1

#223 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 12 November 2019 - 02:31 PM

Scientists in global project to create world's largest human microbiome database

https://www.nutraing...X8FZ7w0m5mR&p2=



sponsored ad

  • Advert
Advertisements help to support the work of this non-profit organisation. [] To go ad-free join as a Member.

#224 albedo

  • Topic Starter
  • Guest
  • 1,393 posts
  • 429
  • Location:Europe
  • NO

Posted 13 November 2019 - 01:51 PM

Additional evidence to keep your Vitamin K in check and its link to gut microbiota and diet. Not only for coagulation and calcium delivery to bones but also for the brain:

Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults

https://www.ncbi.nlm...pubmed/31518386

"...This study provides evidence that although total concentrations of MK did not covary with cognition, certain MK isoforms synthesized by the gut microbiome, particularly the longer chains, are positively associated with cognition..."

 


  • Informative x 2





Also tagged with one or more of these keywords: microbiome

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users