7 replies to this topic

[cortexian4]

hi, it's my first post here.

 

I'm taking "cdp choline + uridine + omega 3 + phosphatidylserine" 

for "safe" and "long-term" improvement of my cognitive enhancement. (actually I cannot sure it is safe and effective)

 

but many user (longecity, reddit)  take "racetam" for maximize their nootropic effect.

 

In my country, nootropic is prohibitted by custom policy.

 

 

1. without racetam, (cdp choline + uridine + omega 3+ phosphatidylserine )would it be sufficient for nootropic effect ??

 

2. is there a huge gap between "racetam stack" and "no racetam stack " ??

 

3. is my stack would be safe in the long-run ?? and any additional supplement welcome :-)

 

 

any inputs appreciated!

 

 

 

 

[Jeoshua]

1. CDP-Choline + Uridine Monophosphate + High DHA Fish Oil + Phosphatidylserine would be an excellent stack. It's kind of a slow burner, tho. Don't expect to see effects immediately, since the activity hinges on neurogenesis and dendritic outgrowth, which can take some time to really show its effects properly.

2. The gap between racetams and many other nootropics is merely in how they feel. Racetams are very obvious when taking them, even if for some people they don't have any good effects other than a slight brightening of the vision. However, many others are non-responders, and find no benefit or effects from racetams, at all.

3. Your stack will be plenty safe in the long run, if you make sure not to switch out some of the supplements for cheaper or less effective versions.

[cortexian4]

thanks for the detailed reply :-)

 

I have another question

 

what would be the proper dosage for each supplements ??

 

and If CDP-choline causes headache, then ALCAR or alpha GPC (or phosphatidylcholine, or choline bitatrate) could be substitute???

 

 

 

 

 

[Jeoshua]

CDP-Choline is the best for the stack you're talking about, since it gives a second source of Uridine in the brain (Citidine converts to Uridine when crossing the Blood-Brain Barrier). Alpha-GPC is also good, a tad more potent but a bit more expensive per effective dose, as well. Choline Bitartrate is alright, not very potent, but dirt cheap.

Dosages (the cholines are options, not to be taken at the same time at these doses):
CDP-Choline - 250mg should be more than enough, and is the most common pill size. This is the kind I use.
Alpha-GPC - 150-200mg would be a good amount. Stay away from the 500mg pills if you're not taking racetams.
Choline Bitartrate - 1-2g is the recommended dosage. I did tell you it was far less potent, right?

Fish Oil - Look for one with a high DHA content. The kind I like is 600mg DHA, 200mg EPA. Take 2.

Uridine Monophosphate - 150-250mg is a good dosage.

Phosphatidylserine - 100mg should suffice.

Note that this stack could exacerbate the effects of some dietary deficiencies, so make sure you take a good multivitamin, or at the very least a B-Complex supplement along with it.

Edited by Jeoshua, 12 April 2014 - 01:28 PM.

[cortexian4]

those dosages looks mild but perfect for me !

 

I realized I have ADD, OCD, compulsive disorder, concetration problems, paranoia..etc.. for 10 years.  (without doctor's diagnosis but It's certain.)

I tried to fix my mind by myself without any help, but failed everytime.

 

I also considered trying tDCS for clinical purpose, but that's bit risky.

 

with this stack, I expect it would gradually ease my depression :-)

more expectation makes less satisfaction, but anyway I really hope to change my desperate mental status.

 

I'll try and report the effectiveness

thank you for GOOD reply!!

 

 

[Jeoshua]

Oh, and if you start noticing increased depressive symptoms, then CDP-Choline might be the cause. I don't know why, but some people report that they feel sluggish and down from it. IF that's the case, switch to Alpha-GPC or Choline Bitartrate.

Myself, I'm ADHD (Type 3, Overfocused/Oppositional) and have struggled a bit with depression, but CDP-Choline makes me feel strangely better. So that's one of those situations where you will only know when you try it.

Edited by Jeoshua, 12 April 2014 - 01:57 PM.

[pbandy1]

good posts Jeoshua!

 

I've personally been wanting to try the UMP, CDP-choline, Alpha-GPC, & ALCAR together with aniracetam and huperzine-A (albeit a very small dose). Wondering what specific B-vitamins were you talking about? I do take B6 and B12 (methyl), but don't really take a complete B-complex/multi (just vitamin D & zinc/magnesium chelates).

[Jeoshua]

I was referring to Folate, primarily, but pretty much anything in the Homocysteine and NAD+/NADH cycles will be affected by taking large amounts of UMP+DHA+Choline. After all, the body needs energy to perform this kind of synthesis, and the energy source and half the "gears" of that system have B-Vitamin written all over it. Specifically:

Thiamine (B1)
Folate (B9)
Cobalamin (B12)
Choline (sometimes thought of as a B Vitamin)

There may be a few more of them involved in this cycle, this is just from memory. For that reason, a broad spectrum B Complex is preferable. I personally prefer the coenzymated versions, like methylfolate and methyl- or adenosylcobalamin, just because it removes one more rate limiting step before their effects can become manifest. Supplementing something like Cyanocobalamin is a good thing, but the body has to convert them into their more usable forms before they become useful, sort of like charging up a battery before you can plug it in to whatever you're trying to power.