5 replies to this topic

[coderbrah]

So a bit of a background: 2 months ago I took a pill of XTC (first time doing drugs in my life btw), it hit me really hard and since then have been having all kinds of issues (strong hypoglycemia, sensory overload, sound & light sensitivity, insomnia and memory loss). Since then I've improved greatly but am still suffering with derealization and depression/anxiety. 

 

I came to the conclusion that my condition has been brought on by serotonin receptor downregulation. In my research I've stumbled upon Inositol as a way to sensitize serotonin receptors. I started taking 2g of Inositol powder before going to bed for 4 days and in those days I started to become progressively worse. First an increase in anxiety and actual panic attacks, then it quickly escalated to feelings of despair and anhedonia, strong fatigue, decreased appetite and brainfog/memory problems. Which is weird because it has helped a bit with my derealization (as far as I can tell).

 

I have stopped taking Inositol 2 days ago and I still have these symptoms albeit not as strong.

 

What could have caused my body to react this way? My own speculation would be that Inositol (combined with my diet and omega 3 pills) also increased the acytelcholine activity in my brain (which apparently was high already). Any ideas?

Edited by coderbrah, 30 April 2014 - 05:56 PM.

[Duchykins]

2g seems too much to start with. I never take more than 400mg of inositol in one dose, sometimes even that seemed too much and I began altering days of 200mg.


Try lysine 500mg-1g, zinc 25-50mg, magnesium 300-400mg. A B-50 complex may assist, but I don't recommend B-100 because it gets you your maximum intake of B6 and the B6 in your foods could easily put you over the 100mg limit.

Then you could reintroduce lower doses of inositol if you like.

Edited by Duchykins, 30 April 2014 - 06:32 PM.

[coderbrah]

2g seems too much to start with. I never take more than 400mg of inositol in one dose, sometimes even that seemed too much and I began altering days of 200mg.


Try lysine 500mg-1g, zinc 25-50mg, magnesium 300-400mg. A B-50 complex may assist, but I don't recommend B-100 because it gets you your maximum intake of B6 and the B6 in your foods could easily put you over the 100mg limit.

Then you could reintroduce lower doses of inositol if you like.

 

What side effects did you get from a 400mg dose that you had to spread it out?

[Duchykins]

2g seems too much to start with. I never take more than 400mg of inositol in one dose, sometimes even that seemed too much and I began altering days of 200mg.


Try lysine 500mg-1g, zinc 25-50mg, magnesium 300-400mg. A B-50 complex may assist, but I don't recommend B-100 because it gets you your maximum intake of B6 and the B6 in your foods could easily put you over the 100mg limit.

Then you could reintroduce lower doses of inositol if you like.

 
What side effects did you get from a 400mg dose that you had to spread it out?

I got migraines. I suppose, given how inositol is supposed to increase serotonin sensitity from my understanding of it, I can assume it's related to the *relatively* sudden dip in serotonin, even if that was followed by an increase in receptor sensitivity, it was too late; the migraine was triggered. Of course this won't happen in most people, they're not susceptible to migraines. That's why common dosage of inositol is 400mg. It also says 400mg dose on the bulk packaging of my inositol.