8 replies to this topic

[ImmortalSpace]

Okay I know theres a lot of hype about this-

but is taking ceramides for someone whos 20 years old (turning 21 in 6 months) a good idea?

I know that ceramides decline as we age and I do have dry skin even though I moisturize daily using sunflower and coconut oil-

Anyways some backround on me, I'm a pescetarian and take Omega 3 capsules daily. My diet is nonpreocessed and I drink a gallon of water daily.

So basically my question is will taking ceramides help me with my dry skin whilst preventing wrinkles from forming for someone my age? I'm so confused, the phytoceramide I bought is made of sweet potato and rice powder with the capsule being gelatin.

Anyone knowledgable in this area please help? It is much appreciated, thank you (: !

[Kenbar]

No one has anything they can share? I am taking them, but can not really comment on results as I take so many other things too....

[krillin]

I haven't done a thorough investigation, but the effects of ceramide on the heart and apoptosis bother me.

 

Basic Res Cardiol. 2014 Nov;109(6):445.

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.

Simon JN, Chowdhury SA, Warren CM, Sadayappan S, Wieczorek DF, Solaro RJ, Wolska BM. 

Abstract 

Although ceramide accumulation in the heart is considered a major factor in promoting apoptosis and cardiac disorders, including heart failure, lipotoxicity and ischemia-reperfusion injury, little is known about ceramide's role in mediating changes in contractility. In the present study, we measured the functional consequences of acute exposure of isolated field-stimulated adult rat cardiomyocytes to C6-ceramide. Exogenous ceramide treatment depressed the peak amplitude and the maximal velocity of shortening without altering intracellular calcium levels or kinetics. The inactive ceramide analog C6-dihydroceramide had no effect on myocyte shortening or [Ca(2+)]i transients. Experiments testing a potential role for C6-ceramide-mediated effects on activation of protein kinase C (PKC) demonstrated evidence for signaling through the calcium-independent isoform, PKCε. We employed 2-dimensional electrophoresis and anti-phospho-peptide antibodies to test whether treatment of the cardiomyocytes with C6-ceramide altered myocyte shortening via PKC-dependent phosphorylation of myofilament proteins. Compared to controls, myocytes treated with ceramide exhibited increased phosphorylation of myosin binding protein-C (cMyBP-C), specifically at Ser273 and Ser302, and troponin I (cTnI) at sites apart from Ser23/24, which could be attenuated with PKC inhibition. We conclude that the altered myofilament response to calcium resulting from multiple sites of PKC-dependent phosphorylation contributes to contractile dysfunction that is associated with cardiac diseases in which elevations in ceramides are present.  PMID:     25280528

[Kenbar]

I haven't done a thorough investigation, but the effects of ceramide on the heart and apoptosis bother me.

 

Basic Res Cardiol. 2014 Nov;109(6):445.

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.

Simon JN, Chowdhury SA, Warren CM, Sadayappan S, Wieczorek DF, Solaro RJ, Wolska BM. 

Abstract 

Although ceramide accumulation in the heart is considered a major factor in promoting apoptosis and cardiac disorders, including heart failure, lipotoxicity and ischemia-reperfusion injury, little is known about ceramide's role in mediating changes in contractility. In the present study, we measured the functional consequences of acute exposure of isolated field-stimulated adult rat cardiomyocytes to C6-ceramide. Exogenous ceramide treatment depressed the peak amplitude and the maximal velocity of shortening without altering intracellular calcium levels or kinetics. The inactive ceramide analog C6-dihydroceramide had no effect on myocyte shortening or [Ca(2+)]i transients. Experiments testing a potential role for C6-ceramide-mediated effects on activation of protein kinase C (PKC) demonstrated evidence for signaling through the calcium-independent isoform, PKCε. We employed 2-dimensional electrophoresis and anti-phospho-peptide antibodies to test whether treatment of the cardiomyocytes with C6-ceramide altered myocyte shortening via PKC-dependent phosphorylation of myofilament proteins. Compared to controls, myocytes treated with ceramide exhibited increased phosphorylation of myosin binding protein-C (cMyBP-C), specifically at Ser273 and Ser302, and troponin I (cTnI) at sites apart from Ser23/24, which could be attenuated with PKC inhibition. We conclude that the altered myofilament response to calcium resulting from multiple sites of PKC-dependent phosphorylation contributes to contractile dysfunction that is associated with cardiac diseases in which elevations in ceramides are present.  PMID:     25280528

Not going to pretend I understand...any of this...but yea that does sound a bit alarming. I keep in mind that many times these test are done with abnormally high amounts...and most often, almost anything in high amounts has some down side effects. My skin seems to look pretty good for my age...but I don't know that I can contribute it to any particular thing. More likely a combo of things...and for all I know somethings I take might, in reality, be working against me. I mess around with C60, DMSO...all kinds of unproven stuff. I also use prescription Retin A .05% on my face for acne control as of late, Suppose to have some nice side benefits as well. But...the skin on my forearms looks pretty good too...and I don't use the cream there. Think I might be seeing the start of some age spots on my hands though....not 100% sure. I am a 58 year young male.

[mustardseed41]

How are you using DMSO?

[sthira]

Longecity is my go-to place to check for anecdotes on scammy products. But here I've find only this one little thread about phytoceramides.

Anyone have happy anecdotal experience to report by taking phytoceramides?

http://www.ncbi.nlm....pubmed/20646083

The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial.
Randomized controlled trial
Guillou S, et al. Int J Cosmet Sci. 2011.

Abstract
Ceramides, specific lipid components of the skin, represent 35-40% of the intercellular cement binding cells together and contributing to skin hydration. A wheat extract rich in ceramides and digalactosyl-diglycerides was developed by Hitex in two forms: wheat extract oil (WEO) and wheat extract powder (WEP). In vitro tests and two clinical studies demonstrated promising efficacy results with WEP on skin hydration. To confirm these early results, a double-blind, randomized, placebo-controlled study was carried out on 51 women aged 20-63 years with dry to very dry skin who received either 350 mg of WEO or placebo for 3 months. Evaluation of skin hydration on legs, arms and face, assessed at baseline (D0) and at study end (D84) was performed by the dermatologist using dermatological scores (dryness, roughness, erythema), skin hydration measurement (corneometry) and self-assessment scores (Visual Analogue Scale: VAS). Perceived efficacy was noted by participants throughout the study; tolerability and overall acceptability of the study products were evaluated by the dermatologist and the participants at the end of study. Skin hydration was significantly increased between D0 and D84 on the arms (P < 0.001) and legs (P = 0.012) in the WEO group compared with placebo. Even if no significant statistical differences between groups were observed for the dermatological evaluation, skin dryness and redness tended to be reduced in the WEO group. Moreover, from D0 to D84, the VAS index had a tendency to increase in favour of WEO for the overall skin hydration (P = 0.084) indicating that participants perceived an improvement. The WEO capsules were perceived by participants as being more effective than placebo on all skin dryness signs. In conclusion, WEO capsules were well tolerated and appreciated. After 3 months' treatment, a significant increase in skin hydration and an improvement in associated clinical signs were observed in women with dry skin.

[ceridwen]

ImI'm putting 4 drops of DMSO into 4oz CDS and taking that every hour

[Ark]

How would one determine if supplementing phytoceramides are useful? (Blood or Skin test?)


Also,that study would make one think this shouldn't be taken very often or at all. Unless you know the benefits out way the risks, I would think the elderly would want to micro supplement this stuff if use it at all.

[Nate-2004]

If it's a scam I dropped a little money to find out. I got a deal with 4 months worth. The amazon reviews were legit according to fakespot but I also checked references and looked at author names and sample sizes. It looks promising but hard to say really. The best way to test anything is with pictures in the same light. I took a ton of pictures in the UK and Croatia this past two weeks and in the UK for some reason I look older. I think it's the overcast skies in Edinburgh and on my last day in London that really showed me that either A: I was eating like crap on this trip and drinking too much (true), or B: None of my efforts this past year have done squat for me. I don't know what's true, but a good test would be to save these pics and then take more in 40 or 50 days in the same kind of light. A midday picture outdoors during a good overcast. I think the light, UV as well, is scattered a lot more on those days and you can get a good idea of how your skin looks that way.

 

Another way is just to use black light or strong florescent light but that doesn't tell you much because for a before and after pic, every single environmental factor has to be the same and not only that, your smile should be the same. 

 

My skin looks great when I'm not smiling, when I smile, here come the deep crows feet that appear out of nowhere (I don't even have fine lines otherwise) that didn't show up till at about 5 years ago.

 

Anyway. I'm trying to fight back here, worst case I wasted money again. That's common in this battle.