Here's an article:
http://www.betterhum...65/Default.aspx
Apparently, lab rats which can't proofread mitochondrial DNA as well, will also suffer faster age-related decline.
So will a study be done with lab rats that have hyperexpression of the DNA proofreader gene? Hopefully, that would show rats with increased lifespan.
Forgive me if I've asked this before, but when you have a single-stranded mutation, how do you tell (how does a proofreader enzyme tell) which is the mutated strand and which is the genuine? I could understand if DNA was 3-stranded, and then the odd man out is obviously the mutant. But when you're 2-stranded, how do you tell which strand is right?