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Negative side effects from piracetam

piracetam negative

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#1 dragomundo

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Posted 05 October 2014 - 05:59 AM


Hello All, I have been a previous reader of these forums for a couple months and have just decided to make an account.

 

I bought 500g of piracetam a couple of weeks ago, with hope and a little too much faith in its ability to improve my cognitive functions.(I could've bought just 1 250g tub but was TOTALLY convinced it would work so I bought 500g). I am a 20 yr old male, 155ish lbs., 6' and very little body fat. I do cardio at least 3 times a week if I have time(some weeks none). I eat lunch and dinner, and take vitamins twice daily(from Standard Process), which include: Cod Liver oil, Catalyn, Hypothalamus PMG, Hypothalamex, Symplex M, Riboneucleic Acid, and their Bacopa and Kava stuff (don't argue with me on how effective these vitamins are, they're free of charge for me also). I am almost done with my associates and am taking Trigonometry, Physics, and Chemistry this semester, making A's in Physics and Trig, and a low B in Chemistry. Oh, and working a 50 hour week at a shop as mainly a janitor, and the odd jobs like oil changes, tire mounts, removing and replacing parts on the rare occasion.

 

I've had a social and general anxiety problem since I was a child, which has improved immensely since then. I also have had a history of major depression in grade school and up to 9th grade from bullies...Until I broke one day and gave him a stab with the tip of my pencil (I felt TERRIBLE and apologized, he didn't tell any of my authorities/teachers, thank god). Never got fucked with after that, that's for damn sure. From there on my depression got exponentially better(not exaggerating the exponential part). I hung out with the drug abusing group in like 10th grade and got into their lifestyle, like popping whatever pills were around and smoking weed EVERY DAY. Yeah its fucking stupid, even dumber, seeing as I was one of the best in my class. This abusing of drugs of course caused rebound depression. But ive learned a huge lesson from that and have been abstinent for a little over 2 years. (I still smoke cigarettes though :S)

 

So now here I was a couple weeks ago thinking that, "Hey maybe these nootropics would give me effects like the people on these forums are describing." So I bought a couple tubs, and some choline bitartrate/inositol mix from Vitamin Shoppe. I was doing about 500-800mg twice a day with 500mg of choline along with it. The first 2 days I felt GREAT and the effects I have noticed were synonymous with the positive effects of other posters. For the next 4 days after that I noticed I was getting brain fog, irritability, MAJOR depression, dry mouth, and other symptoms that I would associate with a "makes you retarded" dose of Benadryl(100-200mg it felt like). I attributed this to my Ach levels depleting so I upped my Choline bitartrate intake to 1500mg to counteract it. It didn't help so I came to the conclusion that I was overly sensitive to piracetam, and lowered my dosage to 400mg twice per day with the usual 1500mg's of choline bitartrate. the next 2 days were the same as before(this is I think the 8th day mark at the end of it), the usual anticholinergic symptoms.

 

By then I was a fucking trainwreck, too depressed to care for studies, wishing that God would kill me every day, and the stupidity caused by the anticholinergic effects intensified the depression. I THEN stopped all usage, and am back to the normal me.

 

One perspective of mine REALLY WANTS piracetam to work, but another perspective is afraid that I will get the same ol' usual, I FEEL RETARDED effects. Fast forward to two weeks later(today), I took a 50mg dose of piracetam about 3 hours ago, and felt as though I was spacing out more than usual, but am pretty sure it is just a placebo(I hope).

 

I am confused on whether I should throw all of my piracetam away(or give it away), or if I should continue experimenting with it in the micro/nano dose range. And I'm also scared that it might build up in my system to eventually give me the usual anticholinergic effects in the long run, maybe causing brain damage from those said effects.

 

Why brain damage you might ask? If you've ever abused Benadryl in your past (yeah I know it was retarded, but this was when I was like 15) youll know what I mean by "damage". :/

 

Yall can debate on the pharmacokinetics/pharmacology of why piracetam effects me in such a bad way, but I want your opinion on what I should do in regards to piracetam intake.

 

Thanks (beforehand) for each and every one of your perspectives that you might give regarding my situation. Im off to bed, c'yall tomorrow fellow longecitiors, longecitiers, w/e you might call it lol :P

 

 


Edited by dragomundo, 05 October 2014 - 06:02 AM.

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#2 dragomundo

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Posted 05 October 2014 - 06:02 PM

Oh and another major point I forgot to add is that the anticholinergic symptoms arose after the stuff had already worn off(for every day). All except for depression which was my only symptom while being affected by the drug.

 

Today I took another 50mg dose of piracetam, with 500mg choline bitartrate at 11am, and tried to do my Physics homework at 12pm.

I am usually proficient in the sciences, but today...dear jesus. I..Do..Not..Get..Physics at the moment... But I sure feel better at writing and stuff lol.


Edited by dragomundo, 05 October 2014 - 06:44 PM.

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#3 Seganfredo

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Posted 02 February 2019 - 06:38 AM

Weirdest thing ever.

Another case of classic Pir negative side-effects.

 

This is just getting insane.


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#4 BioHacker=Life

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Posted 02 February 2019 - 07:22 AM

You are retarded if you think Piracetam is an anticholinergic. Search pubmed for anticholinergic and piracetam and what do you find?

 

1 study that showed Piracetam prevented memory impairment from an anticholinergic drug namely scopolamine. If you don't remember scopolamine it was widely used as a date rape drug and has powerful anti cognitive inducing effects. It other words it counter acts anticholinergics!

 

Neurochem Res. 2013 Aug;38(8):1704-14. doi: 10.1007/s11064-013-1072-6. Epub 2013 May 16.

Piracetam prevents scopolamine-induced memory impairment and decrease of NTPDase, 5'-nucleotidase and adenosine deaminase activities.

 

https://www.ncbi.nlm...pubmed/23677777

 

FYI

 

"Scopolamine, a muscarinic cholinergic receptor antagonist, has been used as a standard/reference drug for inducing cognitive deficits in healthy animals [21, 22]. The effects of scopolamine on memory are associated with a decrease in central cholinergic functions. Furthermore, scopolamine-induced amnesia is associated with decreased glucose oxidation, increase in brain oxidative [23, 24] and decrease of ATP levels in the brain [8, 25]."

 

It actually shares the same mode of action as Benadryl. 

 

https://en.wikipedia...Diphenhydramine

 

"Like many other first-generation antihistamines, diphenhydramine is also a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors) and, as such, at high doses can cause anticholinergic syndrome.[56]"

 

Yet you would have us believe despite Piracetam prevents memory impairments due to antimuscarinic drugs like scopolamine or benadryl it acts just like them? If it had any meaningful anticholinergic effects it would be listed in any studies and as an interaction in the dozens of medical databases. Guess what it's not. At all. But again you think it is and it's as strong as benadryl? You are out of your mind.


Edited by BioHacker=Life, 02 February 2019 - 08:14 AM.

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#5 gamesguru

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Posted 02 February 2019 - 04:46 PM

Dimenhydrinate was also found to have about two times the side effects of piracetam. Drowsiness was found to be the most common side effect of these two drugs


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#6 BioHacker=Life

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Posted 02 February 2019 - 08:53 PM

 

Dimenhydrinate was also found to have about two times the side effects of piracetam. Drowsiness was found to be the most common side effect of these two drugs

 

 

Where is this from? If you're suggesting Piracetam a widely used smart drug approved in over 100 countries actually is a anticholinergic drug you're mistaken.


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#7 gamesguru

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Posted 03 February 2019 - 03:54 AM

Where is this from? If you're suggesting Piracetam a widely used smart drug approved in over 100 countries actually is a anticholinergic drug you're mistaken.

 

it's from a peer-reviewed study.  google the quote and you'll see

 

i'm not implying piracetam is anticholinergic, perhaps antihistamine. not everything is addressed to you or warranting your reaction.  the title of the thread is simply "negative side effects from piracetam", so that's what i'm posting about.

 

You came into this thread and the other one adamant that piracetam had only awesome effects and how anyone who could say otherwise is a scoundrel.  I'm just gently calling you out on the fact, but you keep twisting the truth against us. My teacher told me never to argue with fools, they only drag you down to their level and win with experience

 

Who cares if it's called a "smart drug" or how many countries it's approved in?  X-rays and mercury were once thought to be harmless. And 100 countries have gone to war, does that make war wise?

 

Piracetam can certainly cause contrary effects, so please gtfo.  Also questionable is your inclination that glutamate is always good.


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#8 GABAergic

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Posted 03 February 2019 - 04:22 AM

if piracetam comes out to be detrimental to mental health over long term then it would mean the end of all racetams as we know them since they are all offshoots piracetam. im very curious to follow this and see if piracetam is ever proven to be detrimental long term, but so far to me it just seems a specific case of specific biochemistry at play here. almost impossible to tell if piracetam does anything at all. anyway, i wish we can come to conclusion on this because i am tired of the whole racetam craze and i need definitive answers to them.


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#9 BioHacker=Life

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Posted 03 February 2019 - 04:23 AM

it's from a peer-reviewed study.  google the quote and you'll see

 

i'm not implying piracetam is anticholinergic, perhaps antihistamine. not everything is addressed to you or warranting your reaction.  the title of the thread is simply "negative side effects from piracetam", so that's what i'm posting about.

 

You came into this thread and the other one adamant that piracetam had only awesome effects and how anyone who could say otherwise is a scoundrel.  I'm just gently calling you out on the fact, but you keep twisting the truth against us. My teacher told me never to argue with fools, they only drag you down to their level and win with experience

 

Who cares if it's called a "smart drug" or how many countries it's approved in?  X-rays and mercury were once thought to be harmless. And 100 countries have gone to war, does that make war wise?

 

Piracetam can certainly cause contrary effects, so please gtfo.  Also questionable is your inclination that glutamate is always good.

 

I did and nothing in the study suggest it's anticholinergic the fact that it counteracts anticholinergics makes anyone suggesting it does absurd.

 

Perhaps antihistamine? Are you guessing or just making it up? Do you have a peer reviewed paper on that 2?

 

This thread is years ago bumped by someone who mistakenly thinks some blog post which incorrectly cited several important facts about Piracetam. Facts always come through for those intelligent enough to realize them. Anyone who tries to promote fiction or theories as facts have no standing here.

 

I never said Piracetam is awesome but making false statements from studies or trying pathetically to portray reddit posts as case reports is a utter joke and disservice to those interested in actual clinical data.

 

What facts are you stating? Piracetam can make some people drowsy according to one study? Sure. But saying because of that it works like benadryl gtfooh.

 

Any chemical can have side effects however suggesting Piracetam is dangerous or the ridiculous claim it damages the brain through OD is not based on any research.

 

I've never state glutamate is always good. What the fuck is wrong with you? Your attempts to lie your way into others thinking you're quoting me is disturbing. So do us all a favor and stfu. Keep your fake news on your trump blog.



#10 BioHacker=Life

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Posted 03 February 2019 - 04:26 AM

if piracetam comes out to be detrimental to mental health over long term then it would mean the end of all racetams as we know them since they are all offshoots piracetam. im very curious to follow this and see if piracetam is ever proven to be detrimental long term, but so far to me it just seems a specific case of specific biochemistry at play here. almost impossible to tell if piracetam does anything at all. anyway, i wish we can come to conclusion on this because i am tired of the whole racetam craze and i need definitive answers to them.

 

Piracetam has been around for clinical use since the 60's that's nearly 60 years and it was never pulled from market or shown in anyway to be dangerous to anyone. It is profoundly non-toxic. If there was any issues from it we would have seen it in the massive amount of studies on it. Which is far more than many drugs.


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#11 GABAergic

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Posted 03 February 2019 - 04:28 AM

lol you shouldnt take gamesguru literally. he is always trolling around. sometimes his firm belief of what he thinks is true shines up in his otherwise troll remarks, but in general, he is not good help for anyone on the forum for any advice forwarded to him :/


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#12 GABAergic

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Posted 03 February 2019 - 04:30 AM

Piracetam has been around for clinical use since the 60's that's nearly 60 years and it was never pulled from market or shown in anyway to be dangerous to anyone. It is profoundly non-toxic. If there was any issues from it we would have seen it in the massive amount of studies on it. Which is far more than many drugs.

 

yeah but its still not a huge seller and there are not stats of people using it long term because of internet and people buying it illegally in powder forms or whatever pirate version. unlike pharmaceutical drugs which are prescribed by doctors and all the prescriptions go into a system and everything is in stats and controlled an followed, you cannot really compare long term use of piracetam to any drug really. in fact, supplements in general are like this


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#13 BioHacker=Life

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Posted 03 February 2019 - 04:39 AM

yeah but its still not a huge seller and there are not stats of people using it long term because of internet and people buying it illegally in powder forms or whatever pirate version. unlike pharmaceutical drugs which are prescribed by doctors and all the prescriptions go into a system and everything is in stats and controlled an followed, you cannot really compare long term use of piracetam to any drug really. in fact, supplements in general are like this

 

Not a good seller? It's the most popular nootropic out there and there are several long term studies done on it. Guess what no concerning side effects were ever reported. There's no basis for people to report severe side effects who are taking clinically studied doses. If you're taking tainted piracetam that's outside the discussion as far as i'm concerned.

 

 

 

1. A 28 week study. https://www.ncbi.nlm.../pubmed/3899033

 

2. A 6 month study. https://www.ncbi.nlm...pubmed/21227483

 

3. A 7 YEAR study that used up to 45 GRAMS daily. https://www.ncbi.nlm...pubmed/10338109

 

4. An excellent quote here including phase 4 research. "Recent post-marketing surveillance reports have confirmed the benign safety profile and lack of organ toxicity shown by piracetam during its 25 years of clinical usage. " https://www.ncbi.nlm...pubmed/10338106

 

5. A 1 year study. https://www.ncbi.nlm.../pubmed/8437693


Edited by BioHacker=Life, 03 February 2019 - 04:45 AM.

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#14 gamesguru

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Posted 03 February 2019 - 02:43 PM

Anyone who tries to promote fiction

 

"fictions" like piracetam having deleterious effects?  Not saying permanent damage was done, only that it can cause short-term brain fog.  And we now have studies and anecdotes to back that up, see study quoted in my first post and the people agreeing with me in the other thread.

 

 

lol you shouldnt take gamesguru literally. he is always trolling around. sometimes his firm belief of what he thinks is true shines up in his otherwise troll remarks, but in general, he is not good help for anyone on the forum for any advice forwarded to him :/

 

so because I avoid noopept and dihexa and new kids on the block in favor of more boring and well studied natural stuff, i'm a troll without any good advice?


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#15 BioHacker=Life

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Posted 03 February 2019 - 09:26 PM

"fictions" like piracetam having deleterious effects?  Not saying permanent damage was done, only that it can cause short-term brain fog.  And we now have studies and anecdotes to back that up, see study quoted in my first post and the people agreeing with me in the other thread.

 

 

 

 

 

There's a major difference between the blog suggesting it's causing brain damage and people getting headaches, nausea, or drowsiness.

 

There is NO studies anywhere showing piracetam causes Brain Fog.

 

The majority of people are idiots who agree with whoever sounds like they know what they are saying rather than facts. Let me guess you voted for Trump.

 

You said you have studies backing up Piracetam causes brain fog...OK SHOW ME 1 STUDY AKA PUT UP OR SHUT THE FUCK UP wasting people's time with your unproven theories based on some bro's poorly cited for profit blog post.

 

 

https://www.ncbi.nlm...n fog piracetam

 

Search results Items: 0  No documents match your search terms

 


Edited by BioHacker=Life, 03 February 2019 - 09:30 PM.

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#16 gamesguru

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Posted 03 February 2019 - 10:58 PM

There is NO studies anywhere showing piracetam causes Brain Fog.

 

SHOW ME 1 STUDY

 

 

you won't find "brain fog" in ncbi because it isn't a technical term.

 

 

Comparison of the effectiveness of intravenous piracetam and intravenous dimenhydrinate in the treatment of acute peripheral vertigo in the emergency department.

Drowsiness was found to be the most common side effect
 
Probable Nootropicinduced Psychiatric Adverse Effects: A Series of Four Cases
Ampakines have also been found to cause headaches, somnolence, and nausea.21 Despite the enhancement of long-term cortical neural potentiation with the use of ampakines, shifting cortical neural plasticity in favor of long-term potentiation could lead to impairments in spatial memory and perhaps motor function.
 
Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: a review
Side effects were few and transient, and included insomnia, somnolence, and agitation.
 
Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy.
Two patients reported drowsiness

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#17 BioHacker=Life

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Posted 04 February 2019 - 12:09 AM

you won't find "brain fog" in ncbi because it isn't a technical term.

 

Because it's not a medical condition. There's no test or anyway to measure this so called psychiatric issue some people claim to have. 

 

 

 

Comparison of the effectiveness of intravenous piracetam and intravenous dimenhydrinate in the treatment of acute peripheral vertigo in the emergency department.

Drowsiness was found to be the most common side effect

 

 
 
Drowsiness in people with vertigo injected with Piracetam...guess what vertigo can cause drowsiness and there's no placebo to compare to.
 
"Of the 100 patients treated with dimenhydrinate, 36 experienced side effects – 26 (26.0%) reported drowsiness, 8 (8.0%) dizziness and 2 (2.0%) fatigue. Similar side effects were also recorded in 22 patients treated with piracetam (drowsiness [n = 15, 15.0%] and dizziness [n = 7, 7.0%]) (Fig. 1)."
 
So 15% of people with vertigo who received i.v. Piracetam felt some light degree of drowsiness or 22 out of 100. I don't think anyone is planning on injecting it or has vertigo and regardless it was very effective for their condition. Hardly a dangerous brain damaging side effect given it improved their condition and was safer than dimenhydrinate.
 
But if drowsiness worries you because you think it's going to cause brain damage by all means don't take it.
 

Probable Nootropicinduced Psychiatric Adverse Effects: A Series of Four Cases
Ampakines have also been found to cause headaches, somnolence, and nausea.21 Despite the enhancement of long-term cortical neural potentiation with the use of ampakines, shifting cortical neural plasticity in favor of long-term potentiation could lead to impairments in spatial memory and perhaps motor function.

 

 

 

 

Piracetam is not an ampakine for 1. 2nd these are 4 case reports not a study. But sure let's look at these 4 case reports to see how damaging Piracetam is.

 

Case 1. A 19-year-old male college student with a history of depression and attention deficit hyperactivity disorder (ADHD) presented to the emergency department with psychosis and paranoia resulting in self-injurious behavior. His current medication was bupropion, and historically he had been prescribed methylphenidate but was no longer taking that medication. His parents reported a history of cannabis abuse but he had been abstinent for the past year. No history of psychosis was reported. Previously, the patient was functioning well, in a euthymic state, and was attending his classes. He denied any substance abuse, and urine toxicology was negative. On further questioning, the patient revealed that he was taking a supplement to treat his ADHD. He reported purchasing it online. The supplement was found to be citicoline, and he had been consuming 2 to 3 tablets three times a day for several weeks. The family had noticed some insomnia and irritability early on, but no other concerning behaviors until now. The patient was admitted to the psychiatry department, and his symptoms resolved with olanzapine. He was discharged home in a stable condition and instructed to continue taking olanzapine for one month and to stop using all supplements.

 

 

So nothing to do with Piracetam.

Case 2. A 24-year-old male body builder with a history of anxiety presented to the emergency room with agitation and several days of hypomania. Currently, he was not on any medications, but previously had been treated with paroxetine for anxiety. Several years ago, he used anabolic steroids for a few months, but has not used them since. He reported smoking cannabis on weekends and consuming alcohol occasionally. Urine toxicology was negative. On questioning, he reported recently using cerebrolysin to enhance his cognitive performance, consuming two tablets twice daily. The supplement was obtained from a local health store. The patient received diazepam and was observed overnight. He improved significantly and was discharged home in stable condition. Diazepam was discontinued upon discharge from the hospital. He was instructed to stop all supplements.

 

So nothing to do with Piracetam.

Case 3. A 28-year-old female graduate student presented urgently to the psychiatry clinic for new onset insomnia, anxiety, and panic attacks. She reported a history of depression that was well controlled with psychotherapy. Currently, she was not taking any medications. She denied any illicit substance use and did not consume caffeine or smoke cigarettes. She admitted to being a casual cannabis smoker, but had not been using cannabis recently. The patient reported that she recently started using armodafinil to help her cope with her stressful academic program. Initially, she consumed armodafinil on an as-needed basis, and she felt improved performance and well-being. She then started using it regularly twice daily. Approximately one week later, the symptoms of insomnia, anxiety, and panic attacks began. The patient reported using armodafinil upon the suggestion of a friend, and it was obtained online from an overseas pharmacy. The patient was advised to stop armodafinil and was prescribed clonazepam twice daily until symptoms resolved one week later. At follow-up one week later, up her symptoms had resolved.

 

So nothing to do with Piracetam.

 

Case 4. A 17-year-old male high school student with obsessive compulsive disorder (OCD) and learning disabilities was admitted to the emergency room and then to the psychiatry department for exacerbation of OCD with akathesia and paranoia. He had previously been maintained on fluoxetine with good control of his OCD. He reported no substance abuse or caffeine use, which was confirmed by his parents. Urine toxicology was negative. No history of psychosis or paranoia was reported by the patient or his parents. Basic medical screening showed no abnormalities. On further questioning his parents reported that he had recently started using a supplement for memory. Further investigation revealed that the supplement was piracetam. The parents had not objected to him using the supplement since they perceived it as a safe and “natural remedy.” The supplements were obtained online. His symptoms improved with daily alprazolam and olanzapine at bedtime. Fluoxetine was discontinued. He was discharged home after a short hospital stay in a stable condition on olanzapine at bedtime. Piracetam was discontinued.

 

 

 

So a 17 year old with ocd and alot of other psych issues tried and unknown dose of piracetam and his ocd, akathesia, and paranoia got worse. This means nothing and again none of those have anything to do with "brain fog".

 


Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: a review
Side effects were few and transient, and included insomnia, somnolence, and agitation.

 

 

This is a review article which they cite the study you posted below and 1 other. Since it's not an actual study I'm not going to comment on it directly but only the the cited studies below. Nice try counting this a reference when it's referencing the below study. LOL. This isn't tag along where you can cite 10 studies and all of them are citing 1 study and portray it otherwise.

 

 

7. Fedi M, Reutens D, Dubeau F, et al. Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy. Arch Neurol. 2001;58:781–786. [PubMed]

8. Waegemans T, Wilsher CR, Danniau A, et al. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis. Dement Geriatr Cogn Disord. 2002;13:217–224. [PubMed]

 

 

 

Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy.
Two patients reported drowsiness

 

 

Oh no 2 people in an open study (no placebo) of 11 people had drowsiness for 2 weeks which went away.

 

"Two patients reported drowsiness during the first 2 weeks of treatment."

 

When citing people don't usually edit mid sentence you are purposing trying to hide the fact it was temporary and only lasted 2 weeks. If you're going to hide part of a sentence it is proper to do it like this. Two patients reported drowsiness...". Otherwise it's not much different than lying to people in a pathetic attempt to make your point.

 

Regarding the other reference #8 is also a review study here's the full article. https://sci-hub.tw/10.1159/000057700 But I don't see the quote about side effects so it's Invalid.

 

It's called fact checking and requires effort and thinking. You should get on that.

 

In review of the over 200 studies on Piracetam you found a few case reports, open non placebo study, and 1 small study showing it may cause some drowsiness which appears to be short term yes. Well I'm sorry I value the studies on healthy adults and over 200 studies not showing it to be a serious concern worth even discussing. The clinical relevance of this is nil.


Edited by BioHacker=Life, 04 February 2019 - 12:36 AM.

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#18 gamesguru

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Posted 04 February 2019 - 11:02 PM

Because it's not a medical condition. There's no test or anyway to measure this so called psychiatric issue some people claim to have. 

 

The drowsiness may be short-term because tolerance builds to all effects.

 

If it's impossible to test (or difficult or not a research priority), why discredit anecdotes?  If the very thing in question is hard to establish in the clinical setting but we have people claiming to experience it recreationally, why accuse them of confabulating the effects?  Why not take them seriously?

 

Furthermore there are studies, such as this one (see attached image), but you keep tossing them in the trash.

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#19 BioHacker=Life

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Posted 05 February 2019 - 01:20 AM

The drowsiness may be short-term because tolerance builds to all effects.

 

If it's impossible to test (or difficult or not a research priority), why discredit anecdotes?  If the very thing in question is hard to establish in the clinical setting but we have people claiming to experience it recreationally, why accuse them of confabulating the effects?  Why not take them seriously?

 

Furthermore there are studies, such as this one (see attached image), but you keep tossing them in the trash.

 

Because there's no way to confirm their validity or the cause as they may not disclose all the other drugs they are on, have a health condition that puts them a higher risk, or may dose it differently from what studies recommend which may increase the risk of light side effects.

 

That is not a study. That is a collection of 4 case reports with only 1 on Piracetam and it was a kid with severe issues. Try reading my post above I commented on each of those case reports. That is where they belong. 


Edited by BioHacker=Life, 05 February 2019 - 01:23 AM.

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#20 GABAergic

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Posted 05 February 2019 - 02:51 AM

biohacker, why are so strung out on defending and supporting piracetam use? maybe try noopept, its newer edition


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#21 gamesguru

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Posted 05 February 2019 - 03:16 AM

it was a kid with severe issues.

Try reading my post above

 

well at least you'll have something in common

 

Try making your posts more concise.  There is not even meta-analysis corroborating a statistically significant effect in healthy, young volunteers.  Given the research tends to be positively focused, but fails to establish a clear positive outcome, it is equally likely there is a statistically significant negative outcome which has not been corroborated or investigated by the agencies in charge.

 

I would be even more leery of noopept and its side effects and negative outcomes.

 

from: https://www.ncbi.nlm...pubmed/11296070

Piracetam therapy did not enhance cognition or behavior but was associated with adverse effects.

 

from: https://link.springe...000000000-00000

piracetam exhibited no long-term benefits for the treatment of mild cognitive impairments


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#22 BioHacker=Life

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Posted 05 February 2019 - 05:31 AM

biohacker, why are so strung out on defending and supporting piracetam use? maybe try noopept, its newer edition

 

I'm showing the citations are being improperly used. If someone said a supplement cured cancer based off poor science that showed the opposite I would comment all the same.

 

Noopept is related to Piracetam but with far less research.


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#23 BioHacker=Life

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Posted 05 February 2019 - 05:35 AM

 

 

Try making your posts more concise.  There is not even meta-analysis corroborating a statistically significant effect in healthy, young volunteers.  Given the research tends to be positively focused, but fails to establish a clear positive outcome, it is equally likely there is a statistically significant negative outcome which has not been corroborated or investigated by the agencies in charge.

 

I would be even more leery of noopept and its side effects and negative outcomes.

 

from: https://www.ncbi.nlm...pubmed/11296070

 

from: https://link.springe...000000000-00000

 

Try learning how to read. I know words are hard for you probably a sign you would use some piracetam.

 

You've continually lied on this forum, refused to acknowledge your mistakes, and cite 1 case report as an example of the so called serious negative effects of piracetam. Do you write articles saying kratom kills people but leave out they were also on heroin and cocaine? Seems like it. You're spreading misinformation and seem to be delusionally oblivious to it. Seriously get mentally checked out.

 

 

The majority of all research shows no dangerous or damaging side effects from Piracetam in most people. Some people may notice short term light to mild side effects. Just like any food or supplement. Phase 1-3 and even 4 studies have confirmed this as conclusive.

 

"Post-marketing surveillance has confirmed the benign profile of piracetam and shown that adverse events occur only slightly more often than during placebo administration (Delaere, 1997b)."

 

"Recent post-marketing surveillance reports have confirmed the benign safety profile and lack of organ toxicity shown by piracetam during its 25 years of clinical usage."

 

 

 

It's nearly as safe as sugar pills. Compared to many nootropics it's one of the safest. This data has been published awhile ago. Again learn how to read. Researchers have already reviewed both the studies and it's actual use when being prescribed for 25 years since it was approved and it's been on the market for 60 years. Studied as long as 7 years and there are studies up upwards of 1,000~ patients showing again very few if any light to mild side effects.

 

Why do you think you know more than the researchers and majority of study reports? You don't.


Edited by BioHacker=Life, 05 February 2019 - 05:54 AM.

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