9 replies to this topic

[William Sterog]

PDE4 INHIBITION

PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition [3], improved long term memory [4], increased wakefulness [5], and neuroprotection.[6] [7]

Artichoke Extract is the safest and most effective PDE4 Inhibitor.

 

NCREASING CAMP

An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.

Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory

 

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I'm taking several sustances, including Mindcare by Himalaya, Imperial Adaptogen by Paradise Herbs and The original 7 mushroom blend by Eclectic Institute but I'm interested too in LTP, so, if you have to choose between PDE4 inhibition (artichoke) or increasing cAMP (forskohlii) what would you prefer? Why?

Thanks!

[Metagene]

Neither are preferable: http://www.reddit.co...iltep_debunked/

 

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses.

 

http://www.ncbi.nlm....pubmed/21649644

Edited by Metagene, 26 October 2014 - 11:20 PM.

[William Sterog]

 

Neither are preferable: http://www.reddit.co...iltep_debunked/

 

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses.

 

http://www.ncbi.nlm....pubmed/21649644

 

 

I have the philosophy of only take herbal remedies.

 

Are you sure that Artichoke doesn't inhibit PDE4? Is there any herb solution that works?

Edited by William Sterog, 27 October 2014 - 08:33 AM.

[Galaxyshock]

Avena Sativa (extract) works as a PDE4- and MAOB-inhibitor. I can actually feel it kicking unlike Artichoke for example.

[ceridwen]

Would like to increase CAMP as I have problems with long term memory formation

[William Sterog]

I find out that Hypericum Perforatum, which I used to take, may be the most interesting product for several reasons:

 

Hyperforin has been described as an inhibitor of the reuptake of many neurotransmitters such as dopamine, norepinephrine, serotonin or glutamate. It is thus a potent modulator of synaptic transmission. In addition, it blocks the activity of many receptors such as gamma-aminobutyric acid (GABA) and N-Methyl-D-aspartate (NMDA) receptors. More recently, hyperforin has been shown to activate TRPC6, a Ca(2+)-conducting channel of the plasma membrane, which is the only channel opened by this molecule. Interestingly, the other transient receptor potential channels of C type (TRPC) isoforms (TRPC1, TRPC3, TRPC4, TRPC5 and TRPC7) are insensitive to hyperforin. Due to this specific property, it is now used as a convenient pharmacological tool to investigate the functions of endogenous TRPC6 channels in various cell types. Chronically applied to neuronal cell line PC12, hyperforin promotes the extension of neurites via a mechanism implying TRPC6 channels. It is also known to trigger an intracellular signalling pathway that involves the cAMP-dependent protein kinase A and the transcription factor cyclic adenosine monophosphate response element binding protein (CREB). This leads to an up-regulation of the expression of the brain-derived neurotrophic factor (BDNF) receptor neurotrophic tyrosine kinase (TrkB) and TRPC6. This hyperforin-dependent cascade is controlled by Ca(2+) ions and occurs specifically in the cortex but not in the hippocampus. One key aspect of the cellular responses induced by hyperforin is its impact on the homeostasis of several cations (Na(+), Ca(2+), Zn(2+) and H(+)). In vitro experiments demonstrated that hyperforin, which changes the fluidity of membranes, elevates the intracellular concentration of these elements by promoting their influx and/or their release from internal compartments.

 

 

http://www.ncbi.nlm....pubmed/23816060

Edited by William Sterog, 27 October 2014 - 07:16 PM.

[William Sterog]

It seems like a plant called crotarlaria ferruginea may act like pde4 inhibitor. 

 

 http://www.ncbi.nlm....pubmed/24594242

[medievil]

With my real passport for forskolin the after applying one of my stunts let my brother that looks like me with a fake I'd choose a pde4 inhibitor, all I choose

Haha bit of a silly question this, it depends what affects I'd be after, this thread looks like if you'd be going after LTP.

[William Sterog]

With my real passport for forskolin the after applying one of my stunts let my brother that looks like me with a fake I'd choose a pde4 inhibitor, all I choose

Haha bit of a silly question this, it depends what affects I'd be after, this thread looks like if you'd be going after LTP.

 

Of course I'm after LTP.

[Thew]

I would prefer Increasing Camp, herbal supp might work for you.