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Piracetam and the Kidneys - Is it damaging or not?

piracetam safety kidneys

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#1 Tesla

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Posted 31 January 2015 - 03:38 AM


A few years back, I used to take piracetam 5-9g daily for a couple of months with TREMENDOUS results. Not too sure why I stopped.

 

Either way, few months ago (years after piracetam) experienced excruciating pain on my left flank--turned out to be a medium sized (3.6mm, just small enough not to be ultrasonically destroyed, large enough to hurt worse than giving birth) kidney stone making an escape to my bladder. Horrible time. Took 3 weeks to pass and a lot of codeine. Doc says my kidneys are just fine now.

Everything is all good now. Turned out to be a calcium stone, so unrelated to piracetam. Funny that I say this, but it was caused by my attempt at the paleo diet... I forgot to drink enough water. Hah! That's what I get for eating all those animals. Got me thinking about my long-term kidney health in general. Cut out sugars. Started drinking upwards of a gallon of water a day. Monitor my pH and protein as to not put stress on my kidneys. Feelin' good.

Wanted to add piracetam back into the mix, but was concerned at the potential implications upon the kidneys. I've heard people say that piracetam is excreted solely by the kidneys... so if I'm ingesting 9g of this chemical a day, isn't that a ton of stress? 

Is it true that piracetam can damage the kidneys? Are there any studies on the affects of piracetam on the kidneys that you guys know of?--or any recommendations?



#2 StevesPetRat

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Posted 31 January 2015 - 09:29 AM

Piracetam increases red blood cell deformability, so the net effect may be increased blood flow to the kidneys. It appears beneficial in certain circumstances:

http://www.ncbi.nlm..../pubmed/3188196

https://www.google.c...tents/US8686037

It is my suspicion that some people getting "kidney pain" with piracetam are in fact depleted of aldosterone; maybe the adrenal glands get sore trying to keep up with demand. I dunno.



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#3 maik2013

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Posted 02 August 2015 - 08:35 AM

Hi I'm taking 18g Piracetam daily at the moment. I'm drinking lots of water with it. Should i check my kidneys? Are those home urine tests enough?

 

Kind Regards



#4 Tesla

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Posted 27 February 2016 - 02:39 PM

Hi I'm taking 18g Piracetam daily at the moment. I'm drinking lots of water with it. Should i check my kidneys? Are those home urine tests enough?

 

Kind Regards

 

Checking on your kidneys with a doctor would be wise! I don't think home tests are enough. There are many parameters for kidney function that can only be determined by blood tests



#5 maik2013

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Posted 27 February 2016 - 05:05 PM

I stopped the high doses anyway.



#6 Tesla

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Posted 28 February 2016 - 11:27 PM

I stopped the high doses anyway.

 

Oh yeah? How was your experience with 18g?



#7 maik2013

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Posted 29 February 2016 - 09:38 AM

I was very qualitatively productive. But it could also be contributed to the fact that it was summer(can't stand winter), i exercised a lot and i used ephedrine too. I had one very bad day with shivering and racing heart so i stopped the ephedrine completely. I think it's hard to replicate those feelings, but yes, if i'm already working it enhances the quality of the work, but low doses do that too, i also think it enhances male balding pattern and there is a tolerance issue. First of all my base state was elevated already due to summer. I call this baseline nutrition. It basically means that you have to identify your root problem. In my case it is lack of focus, motivation and energy. This has several reasons, most of them health related, but during the summer this base is already elevated. If you already work hard and you're very focused and you need more intellect then maybe Piracetam is for you. But if you have my problems you probably might try other things. Which brings me to my second problem. Most things that do work, do so only temporarily. I basically looked back at the last three years, which saw me testing hundreds of supplemements and methods, and i took the things that worked best for me and i'm cycling them now within a week(example: Phenylpiracetam or Mucuna Pruriens mini dose).  The third most important thing is tracking. I have seen countless things that make me more physically active and feeling good, but i had zero improvements in my personal index. I have several weighted parameters in an excel sheet, which combine to a daily, weekly and monthly index. 

There is no wonder cure, but minidosing and cycling is my way to go at the moment, but i have to admit that i'm not ahead money wise so far, but i'm working on my projects more than ever. 

 

I take Piracetam 1.2g on four days a week currently, i just don't need more intellect, my problem is solely focus, motivation and energy. But if you work hard on a complicated project and you need a breaktrough in terms of quality, a megadose Piracetam for a limited number of days might help.

 

Kind regards



#8 BlueCloud

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Posted 29 February 2016 - 10:49 AM

Guys, the real question is : do you really need doses that high ? MOAR isn't always synonymous of better, and this recent trend of megadosing Piracetam is doing more harm than benefit. The usual prescribed doses of Piracetam are usually around 1600 to 2400mg (give and take) per day, and for a long time that's what most people were taking and safely enjoying the benefits. It's only recently that we started seeing forums filled with people advising to eat a baril of powder per day ( yes, i' m thinking for example of that post by ScienceGuy ), with dubious benefits most of the time since Piracetam , like many other substances , has a bell-shaped curve of efficacy.


Edited by BlueCloud, 29 February 2016 - 11:34 AM.


#9 Turnbuckle

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Posted 29 February 2016 - 12:37 PM

Guys, the real question is : do you really need doses that high ? MOAR isn't always synonymous of better, and this recent trend of megadosing Piracetam is doing more harm than benefit. The usual prescribed doses of Piracetam are usually around 1600 to 2400mg (give and take) per day, and for a long time that's what most people were taking and safely enjoying the benefits. It's only recently that we started seeing forums filled with people advising to eat a baril of powder per day ( yes, i' m thinking for example of that post by ScienceGuy ), with dubious benefits most of the time since Piracetam , like many other substances , has a bell-shaped curve of efficacy.

 

 

Some info on the dose response curve for piracetam--

 

Piracetam is one of the best examples of the U-shaped bell curve dose-response with the optimal range lying between 2.4 - 4.8 grams per dose, 2-3 times per day. On average, efficacy of piracetam increases sharply as the user approaches the peak of the dose-response curve and benefit drops and negative peripherals increase as you go past the peak of the bell curve right there at 4-4.8 grams

 

http://www.focussupp...-response-curve

 

 

 

So the most effective total daily dose is somewhere around 8 to 15 grams, according to this source (which unfortunately doesn't include any references or allowance for body weight).

 

Another source gives these rough guidelines--

 

Quick Facts About Piracetam Dosage and Usage
Safe Piracetam Dosage 400mg to 4800 mg
Piracetam Attack Dose Twice the normal dose - Up to 4.8gr taken twice a day.
Piracetam Maximum Dose It is not recommended to take more than 9.6 grams in a 24 hour period of time.
Piracetam half-life Piracetam has a half-life of 4-5 hours.
How long does piracetam last? Approximately 30 hours
Best choline sources for piracetam Alpha GPC, CDP Choline (Citicoline)
 

 

 

 


Edited by Turnbuckle, 29 February 2016 - 12:50 PM.


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#10 cat-nips

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Posted 22 August 2019 - 03:26 PM

Similar experience the last 2 times I took Aniracetam at normal doses ~750mg.  Co-administered with only Alpha GPC which I have taken independently without those effects.  The pain was enough to keep me immobilized for a few hours, unable to get up, contemplating a hospital visit, and lingered until the next day until gradually subsiding.  I never had any prior issues with racetams before this, but the severity of the last two times is enough to leave me nervous.  I also have somewhat of a paleo-ish diet, and probably not enough water, but it's definitely triggered by Aniracetam.  Wondering if it's kidney related.  Did you resume Piracetam without any further issues?  Found any insight into this?







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