6 replies to this topic

[reason]

The brain is impacted by the processes of degenerative aging for decades before the damage rises to noticeable levels. When the technologies exist to repair this damage, treatments should ideally begin in the middle of life, not wait until there are obvious signs of degeneration. Prevention beforehand is better than restoration after the fact, for all that most of us are, at best, going to forced along the restoration route given the prospective timelines for the development of repair therapies:

Typical cognitive aging may be defined as age-associated changes in cognitive performance in individuals free of dementia. To assess brain imaging findings associated with typical aging, the full adult age spectrum should be included. Researchers compared age, sex and APOE ɛ4 effects on memory, brain structure (as measured by adjusted hippocampal volume, HVa) and amyloid [brain plaques associated with Alzheimer disease] positron emission tomography (PET) in 1,246 cognitively normal individuals between the ages of 30 and 95.

Overall memory worsened from age 30 through the 90s. HVa worsened gradually from age 30 to the mid-60s and more steeply after that with advancing age. Median amyloid accumulation seen on PET scans was low until age 70 but increased after that. Memory was worse in men than women overall, especially after 40. The HVa was lower in men than women overall, especially after 60. For both males and females, memory performance and HVa were not different by APOE ɛ4 carrier status at any age. From age 70 onward, APOE ɛ4 carriers had greater median amyloid accumulation seen on PET scans than noncarriers.The ages at which 10 percent of the population was "amyloid PET positive" were 57 years for APOE ɛ4 carriers and 64 years for noncarriers. Amyloid PET positive indicates individuals are accumulating amyloid in their brain as seen on PET scans and, while they may be asymptomatic, they are at risk for Alzheimer disease.

"Our findings are consistent with a model of late-onset AD [Alzheimer disease] in which β-amyloidosis arises later in life on a background of preexisting structural and cognitive decline that is associated with aging and not with β-amyloid deposits."

Link: http://media.jamanet...he-aging-brain/

View the full article at FightAging

[corb]

 

The brain is impacted by the processes of degenerative aging for decades before the damage rises to noticeable levels. When the technologies exist to repair this damage, treatments should ideally begin in the middle of life, not wait until there are obvious signs of degeneration.

 

If there's one thing I'm completely sure SENS can't take care of it's "normal" brain aging.

The focus of SENS is amyloids but amyloidosis happens much later in the lifespan, decades after the brain has already started to lose functionality and mass.

I suspect the SENS philosophy of letting the damage happen and then repairing it once in a while is fundamentally flawed in the context of postmitotic tissues.

 

[niner]

If there's one thing I'm completely sure SENS can't take care of it's "normal" brain aging.

The focus of SENS is amyloids but amyloidosis happens much later in the lifespan, decades after the brain has already started to lose functionality and mass.

I suspect the SENS philosophy of letting the damage happen and then repairing it once in a while is fundamentally flawed in the context of postmitotic tissues.

 

I don't think that the SENS philosophy is to let the damage happen; it's more like fixing the damage periodically before it gets bad enough to notice.  The problem is that at the moment, SENS doesn't have much to offer people who need help now.  There's also a curious anti-supplement bias among many SENS fans, so I suppose the idea of doing something to prevent or slow the development of AD, like using a forumulated curcumin, would be considered "silly".  Needless to say, I find this attitude troubling.

[GhostBuster]

 

If there's one thing I'm completely sure SENS can't take care of it's "normal" brain aging.

The focus of SENS is amyloids but amyloidosis happens much later in the lifespan, decades after the brain has already started to lose functionality and mass.

I suspect the SENS philosophy of letting the damage happen and then repairing it once in a while is fundamentally flawed in the context of postmitotic tissues.

 

I don't think that the SENS philosophy is to let the damage happen; it's more like fixing the damage periodically before it gets bad enough to notice.  The problem is that at the moment, SENS doesn't have much to offer people who need help now.  There's also a curious anti-supplement bias among many SENS fans, so I suppose the idea of doing something to prevent or slow the development of AD, like using a forumulated curcumin, would be considered "silly".  Needless to say, I find this attitude troubling.

 

 

The problem with supplements is that they are not sustainable. There are so many supplements that might be good for you, but it's a difficult task to keep feeding yourself with supplements for many years let alone decades. Especially so if you don't "feel" the supplement in any way, althought you might "know" that it is the real deal. To make it even worse, it's hard to believe that supplements are any good for longevity if you don't eat them for many years/decades.

[Logic]

Amyloidosis:

 

Excess antibody protein fragments produced by bone marrow build up in the bloodstream and are then deposited between cells in body tissue.
Chronic infections and inflammatory disease speed up the process.

This points to the elimination of, or at least the minimization of, infection as important in minimising Amyloidosis.

 

http://www.longecity...ndpost&p=597470

 

http://www.longecity...infected-cells/

 

http://www.longecity...m-bacteria-100/

Edited by Logic, 20 March 2015 - 04:06 PM.

[niner]

 

I don't think that the SENS philosophy is to let the damage happen; it's more like fixing the damage periodically before it gets bad enough to notice.  The problem is that at the moment, SENS doesn't have much to offer people who need help now.  There's also a curious anti-supplement bias among many SENS fans, so I suppose the idea of doing something to prevent or slow the development of AD, like using a forumulated curcumin, would be considered "silly".  Needless to say, I find this attitude troubling.

 

The problem with supplements is that they are not sustainable. There are so many supplements that might be good for you, but it's a difficult task to keep feeding yourself with supplements for many years let alone decades. Especially so if you don't "feel" the supplement in any way, althought you might "know" that it is the real deal. To make it even worse, it's hard to believe that supplements are any good for longevity if you don't eat them for many years/decades.

 

How are they not sustainable?  In a lot of cases, "feeling" the supplement isn't useful; the point of the supplement is to keep something bad from happening, not change you.  In other cases, you can certainly feel things.  Sometimes we have clinical markers that we can use as guidance.  Lacking that and lacking any deeper understanding of your condition and the workings of the vast pharmacopeia that we lump under the term "supplements", my advice would be to go minimal.  There are absolutely going to be compounds that you don't have to take daily for decades to benefit from:  They are called "senolytics".  You might take them every couple years.  As for having to eat anything for many years/decades, that's true for food and water-- does that make them unsustainable?  Moderate supplementation is just part of a healthy lifestyle.

[GhostBuster]

 

 

I don't think that the SENS philosophy is to let the damage happen; it's more like fixing the damage periodically before it gets bad enough to notice.  The problem is that at the moment, SENS doesn't have much to offer people who need help now.  There's also a curious anti-supplement bias among many SENS fans, so I suppose the idea of doing something to prevent or slow the development of AD, like using a forumulated curcumin, would be considered "silly".  Needless to say, I find this attitude troubling.

 

The problem with supplements is that they are not sustainable. There are so many supplements that might be good for you, but it's a difficult task to keep feeding yourself with supplements for many years let alone decades. Especially so if you don't "feel" the supplement in any way, althought you might "know" that it is the real deal. To make it even worse, it's hard to believe that supplements are any good for longevity if you don't eat them for many years/decades.

 

How are they not sustainable?  In a lot of cases, "feeling" the supplement isn't useful; the point of the supplement is to keep something bad from happening, not change you.  In other cases, you can certainly feel things.  Sometimes we have clinical markers that we can use as guidance.  Lacking that and lacking any deeper understanding of your condition and the workings of the vast pharmacopeia that we lump under the term "supplements", my advice would be to go minimal.  There are absolutely going to be compounds that you don't have to take daily for decades to benefit from:  They are called "senolytics".  You might take them every couple years.  As for having to eat anything for many years/decades, that's true for food and water-- does that make them unsustainable?  Moderate supplementation is just part of a healthy lifestyle.

 

 

How many people are going to eat handful of supplements for the rest of their lives? Eating supplements is not a pleasure, they are not nice to swallow and the taste is not so good etc. They also cost quite of lot if you count the life time costs. If you quit eating supplement X, the money used was probably in most cases the waste of time and money (so think carefully before you get married...). Ok, if you have a condition which is why you eat a supplement (and you notice it helps), then you may be motivated to take your supplements faithfully. In most cases at some point (young) people just quit taking supplements they had been taking. I have dropped every supplement I have been taking except vitamin D3, which have had noticeable benefits. Some supplements I restart every now and then, for example a multivitamin.

Edited by GhostBuster, 23 March 2015 - 11:25 AM.