27 replies to this topic

[lifemission]

I'm 26 years old...should I hold out on using this until later in life, or is it of greater benefit to start now?

[LifeMirage]

I'm 26 years old...should I hold out on using this until later in life, or is it of greater benefit to start now?

You can start low doses like 1 mg every other day.

[losty]

Gdamn....... I better seriously rethink the 5mg a day was taking for a while.....Im 23

Ive read of ppl on this forum taking 10mg a day....

[liorrh]

if the half life of deprenyl is so long wouldnt taking 5mg everyday result in MAO-A inhibition also?

[zorblart]

i'm 25 and take 5 mg daily but it's just me

im 22 and thinking about doing the same (taking 5mg a day that is)

what benefits have you noticed?


cheers,
zorblart

[liorrh]

where do you sell it?
I must say that I can't tolerate 5mg more than 2-3 days in a row. a pitty.
what supplements are you taking with? anything synergistic like DLPA, Tyr? Gaba/theanine?

[lemon]

For someone who is healthy and in their 20's no more than 1mg should be taken a day. I don't know of any studies of healthy people in their 20's taking, say, 5mg a day.

5 mg a day, ultimately is gambling your long term health. I realize the short term effects are nice (as they are for alot of street drugs ).

[olav23]

Someone should also mention that the absorption rate is different from the Tabs vs the sublingual Selegiline. I'm not sure of the comparison off-hand but I believe much more is absorbed sublingually over the tablets.

[lifemission]

Da Sense do you take NAC, Vitamin C and or Vitamin E?
Theres a bunch of info on the site below about how it's good to supplement with these due to the increased SOD. It is said that NAC, Vit C and E can help keep a balance and deal with the levels of hydroxy radicals produced by SOD upregulation.

A personal note: After all this, sometimes confusing, information about deprenyl, you are probably wondering how much, if any, deprenyl I take. In 1989, I began taking 15 mg. a week. I soon reduced the dosage to 5 to 10 mg. of deprenyl weekly. In 1996, I reduced my dose to 5 mg. a week and started using liquid deprenyl citrate. I also take 1000 mg. of NAC per day and at least 800 I.U. of vitamin E and 3200 mg. of vitamin C per day.

See the preceding context of this quote here> http://www.futuresci...m/deprenyl.html

Do you folks here think that I would be better off taking modalert rather than deprenyl at my age? It may sound like a dumb question since deprenyl seems so safe, but I don't really want to mess with my life span (shorten it) because I started deprenyl at too young of an age.. maybe a tough question to answer but opinions are fine with me..
I'm looking to improve my mood and motivation/productivity...Life Mirage mentioned that it would be ok to take 1mg every other day, but would this even cause any noticable improvements? I guess this depends on my current dopamine levels?
Is it that much of a fine line between increasing/decreasing a persons lifespan?

[liorrh]

Hi da sense, I took tianeptine and dep together for two months. I will chime in later on my results, got to run to the gym...

[REGIMEN]

tianeptine and deprenyl...sounds like something I should try.
Would taking 5-HTP and DLPA be a good addition to take with each of these, respectively ... kind of like serotonin and dopamine 'fuel' for the 'fuel injectors' of Tia and Dep? I'm rather retarded on these things. LifeMirage, rally!

[wannafulfill]

this has been brought up many times, but no one found any real studies showing possible long term negative side effects of deprenyl

No one can present any real studies showing long term ANYTHING with deprenyl in healthy humans... because the research doesn't exist.

[vastman]

wannafulfill....your comments apply to most of the 80-95 caps a day I consume...however, the laboratory work and related research/evidence is sufficiently overwhelming to me that I choose to invest in this endevour....

It is unfortunate that no one is monitoring my chemistry...or anyone elses for the long run... clarity is always nice to have... But I can't wait that long....

[rfarris]

How does body weight effect the suggested quantity of deprenyl? If the normal quantity is intended for a 175 lb male, what would be the suggested quantity for a 350 lb male?

[rfarris]

At UN it is suggested that you take 1/4 to 1/2 5mg tablet with each meal. That seems like a lot of work. If you intended taking, say, 15mg per week, would there be a big difference to taking a 5mg tablet 3 times a week, or is it really important to split those pills and taking them spread across your meal plan?

[rfarris]

Oh, believe me, I spend a couple of hours every day digging through this place, but, there are a lot of posts here, and as with all online resources, within a half dozen posts for a typical topic, the topic title usually doesn't relate to the posts. A good example is this one "Deprenyl: How young is too young?" (I'm as bad as anyone.) That makes it difficult to find relelvant information, sometimes. That's just the way it is online.

When you say:
> ... if it's mao inhibition you can take it once per week, if it's a dopamine boost
> then you should take it daily ...

Do you mean that taking small amounts daily would give me a small daily amount of dopamine boost, as opposed to taking all of the weekly amount would give me one big dopamine boost? Or that there would be *no* dopamine boost?

If the first, then I might be willing to live with the 3-times-a-week regimen...

[johnmk]

Keep in mind MAO-B exists pretty much only in glial cells. Most dopamine in the interesting parts of the brain that you folks are likely more interested in (PFC, etc.) is broken down by MAO-A which selegiline at the doses you are taking will likely not even begin to touch. I don't think many are aware of that, and also the cognitive effects from MAO-B inhibition are, as far as I am aware, not altogether well-known. Please correct me if I am wrong here. What would be truly interesting is to find out precisely what the function of glial cells are, and what effect MAO-B inhibition within them has for the rest of the brain.

Edited by johnmk, 05 September 2005 - 08:22 PM.

[rfarris]

Da Sense writes:
> ... 2-3 times a week is a good anti aging schedule (depending on your age ...

Thanks, Da. I'll be 54 next week. As a quick introduction I'll mention that I had a stroke in March (the cerebral hemorrhagic kind) and luckily came out of it with no physical problems, although I did lose about 10% of my vocabulary. Some friends from Poland loaded me up with Swiss Nootropil (piracetam) and insisted I take some every day. When I ran out (as did they) I found UN, and started getting my piracetam there.

As generally being considered a master-level journeyman software engineer, it was quite scary to find out that describing various technical topics related to computer science was sometimes impossible for me.

Then I noticed Steve's "stack," and I added aniracetam, oxyracetam, Hup-A and Alpha-GCP. After a couple of months I'm finding my brain coming back.

Then I found this place and now I'm thinking of adding deprenyl and Hydergine.

Thanks for the help.

[johnmk]

Thank you for sharing your story with us rfarris. Keep in mind the brain takes care of itself, as well, and it will attempt to repair itself of its own accord with or without nootropics -- you cannot be sure you wouldn't be where you are right now regardless. Nevertheless I think you are wise to consider nootropics both in improving your cognitive function and in helping to prevent future decline.