• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Resveratrol Activates SIRT3 to improve cardiac function

resveratrol sirt3 heart improves function

  • Please log in to reply
No replies to this topic
⌛⇒ write a quiz!

#1 Anthony_Loera

  • Life Member
  • 3,128 posts
  • 713
  • Location:Miami Florida

Posted 03 May 2015 - 04:26 PM


Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway.

Am J Physiol Heart Circ Physiol. 2015 Mar 1;308(5):H424-34

Authors: Chen T, Li J, Liu J, Li N, Wang S, Liu H, Zeng M, Zhang Y, Bu P

 

Abstract
Sirtuins [sirtuin (SIRT)1-SIRT7] mediate the longevity-promoting effects of calorie restriction in yeast, worms, flies, and mice. Additionally, SIRT3 is the only SIRT analog whose increased expression has been shown to be associated with longevity in humans. The polyphenol resveratrol (RSV) is the first compound discovered able to mimic calorie restriction by stimulating SIRTs. In the present study, we report that RSV activated SIRT3 in cardiac fibroblasts both in vivo and in vitro. Moreover, in wild-type mice, RSV prevented cardiac hypertrophy in response to hypertrophic stimuli. However, this protective effect was not observed in SIRT3 knockout mice. Additionally, the activation of SIRT3 by RSV ameliorated collagen deposition and improved cardiac function. In isolated cardiac fibroblasts, pretreatment with RSV suppressed fibroblast-to-myoblast transformation by inhibiting the transforming growth factor-β/Smad3 pathway. Therefore, these data indicate that the activation of SIRT3 by RSV could ameliorate cardiac fibrosis and improve cardiac function via the transforming growth factor-β/Smad3 pathway.

 

PMID: 25527776 [PubMed - indexed for MEDLINE]

 

Cheers

A







Also tagged with one or more of these keywords: resveratrol, sirt3, heart, improves, function

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users