Increased activity of Catalase, Superoxide
Dismutase, Glutathione reductase, as well as an increase in the
reduced, oxidized, and total glutathione content
Exp Gerontol. 2005 Aug 30.
Modulatory effects of centrophenoxine on different regions of ageing
rat brain.
Bhalla P, Nehru B.
Department of Biophysics, Panjab University, Chandigarh 160 014, India.
The debilitating consequences of age-related brain deterioration are
widespread and extremely costly in terms of quality of life and
longevity. Free radical induced damage is thought to be responsible, at
least in part, for the degenerative effects of aging. This may be
largely due to high-energy requirements, high oxygen consumption, high
tissue concentration of iron and low of antioxidant enzymes in brain.
Therefore, supplementing an external source of free radical scavenger
would greatly benefit in ameliorating the free radical damage which may
thus be beneficial in aging. In the present study, an important
nootropic agent Centrophenoxine, which has an easy access to brain, has
been administered to aged animals (16 months old). Rats aged 6 months
(young group) and 16 months old (old group) were chosen for the study.
Both groups were administered Centrophenoxine (dissolved in
physiological saline) intraperitoneally once a day for 6 weeks. Our
study indicates an increased activity of Catalase, Superoxide
Dismutase, Glutathione reductase, as well as an increase in the
reduced, oxidized, and total glutathione content thus resulting in an
altered redox state. A substantial increase in the malondialdehyde
content was also reported as a result of aging. Whereas, following
Centrophenoxine administration (100mg/kg body weight/day, injected i.p)
alterations in the activities of Superoxide dismutase, Glutathione
reductase as well as in the reduced and oxidized glutathione content
was reported in aged rat brain. Lipid peroxidation was also reported to
be significantly decreased in aged animals after Centrophenoxine
supplementation for 6 weeks. The use of an extraneous antioxidant
substance may prove beneficial in combating the conditions of oxidative
stress in ageing brain.
PMID: 16137852 [PubMed - as supplied by publisher]
http://www.ncbi.nlm....852&query_hl=17
Edited by scottl, 03 September 2005 - 09:38 PM.
