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hyperforin

st. johns wort depression premature ejaculation

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#1 Valor5

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Posted 03 June 2015 - 05:50 PM


Hello, I have not been on here as much as in the past but I have been lurking. Today, because of my mental problems, depression, lack of interest in anything, I ran into an abstract relating the fact that hyperforin delays ejaculation in rats. I thought that was interesting. I have been taking some perika for some time but it seems it does next to nothing, to be honest I take a number of things and maybe not as consistently as I should but I am somewhat consistent. That being said. I really feel nothing from the perika. So back on point, the delay in premature ejaculation in that abstract was at a dose of 5mg to 80mg/kg in the rat. Here is my concern. I feel like the dose is way too small in the perika. I would like to know if there is anyway we could get someone to make us higher amounts of hyperforin, not the measly weak amounts found in the perika.



#2 Valor5

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Posted 03 June 2015 - 09:25 PM

A little update. I took ten perika pills and it felt like it made a huge difference. But at that rate the bottle would be empty in 6 days. Also my stomach started to hurt not too bad but still uncomfortable. Wish I knew what was causing it, might be the magnesium stearate and the stearic acid. I've heard that causes nausea.

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#3 burnlife

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Posted 03 June 2015 - 10:57 PM

 What kind of difference did it make?



#4 Valor5

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Posted 04 June 2015 - 04:00 AM

 What kind of difference did it make?

 

Felt more talkative and bold. Down-side was slight diarrhea and stomach discomfort.



#5 toto75015

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Posted 04 June 2015 - 08:21 AM

My experience with perika is that it takes some weeks to start feeling the effects but when it kicks it is obviously not placebo. I'm not consistent in my perika use because even if it lift the depression I don't like how I feel when I took it for too long. It kind of dulls my emotions, I feel flat and slow. But from time to time it helps.

Did you take it consistently for at least 4 weeks at the recommended dosage?

Given the potency of this brand I warn you against ingesting so much at once, I don't believe it's safe for your brain.

#6 Valor5

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Posted 04 June 2015 - 12:06 PM

My experience with perika is that it takes some weeks to start feeling the effects but when it kicks it is obviously not placebo. I'm not consistent in my perika use because even if it lift the depression I don't like how I feel when I took it for too long. It kind of dulls my emotions, I feel flat and slow. But from time to time it helps.

Did you take it consistently for at least 4 weeks at the recommended dosage?

Given the potency of this brand I warn you against ingesting so much at once, I don't believe it's safe for your brain.

 

Hey toto75015, thanks for your concern. The bottle says to take three a day separated. I have 23 left meaning that before yesterday I had 33. So, If you divide that by the recommended dose I more or less took it for ten days and it did nothing that I could honestly say, there is something here. I am going to keep on with what I have, really just another two days worth, but for the sake of science and others I think this is worthwhile. I am going to take it after eating something. Hopefully this time I won't get diarrhea or nausea. I am thinking of stopping my other stuff, also.

 

 


Edited by Valor5, 04 June 2015 - 12:06 PM.


#7 toto75015

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Posted 05 June 2015 - 10:45 AM

If I were you I would stick with the recommended dosage for at least one month before judging. It is not an instant medication, it can take time. I don't believe that taking mega dose is safe.

On the other hand your problem may be unrelated to what hyperforin can help so may be this is not for you. But you should decide only after proper testing ie at least one month with the recommended dosage.

I know people over sensitive to perika that can feel it the first week generally not in a good way (dulled emotions, slowness...).

Strange that you feel nothing.

#8 Valor5

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Posted 05 June 2015 - 04:14 PM

If I were you I would stick with the recommended dosage for at least one month before judging. It is not an instant medication, it can take time. I don't believe that taking mega dose is safe.

On the other hand your problem may be unrelated to what hyperforin can help so may be this is not for you. But you should decide only after proper testing ie at least one month with the recommended dosage.

I know people over sensitive to perika that can feel it the first week generally not in a good way (dulled emotions, slowness...).

Strange that you feel nothing.

 

Hey toto75015, yesterday I took ten before noon and I can't say anything remarkable happened, in fact I felt like I was going somewhat backwards with forgetfulness and absent-mindedness coming back. So, I got a little frustrated and took 5 more and my other true and tested stuff and I felt cool and collected at work. This does not dull my emotions, in fact yesterday a girl irritated me but I was able to perform at work at a precise level. I have 9 left. I am thinking the first time I tried it, it may have caused a down-regulation and that is why the second time it did nothing, or felt like nothing. I am of the opinion of a higher dose is much better. The nausea did not bother me as much yesterday. I took it about an hour after eating. I wish I could inject hyperforin or maybe even inhale it or something. I throw so much stuff into my stomach that it just gets ridiculous and then my stomach becomes my worst enemy.



#9 toto75015

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Posted 05 June 2015 - 05:26 PM

Wow! That is strange. I never tested such a huge dose, but I am pretty sure that it would hurt me... I don't know the rest of your stack but it doesn't seem safe to mega dose on so many chemicals.

What is the root cause of your problem?

#10 Valor5

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Posted 05 June 2015 - 07:30 PM

Wow! That is strange. I never tested such a huge dose, but I am pretty sure that it would hurt me... I don't know the rest of your stack but it doesn't seem safe to mega dose on so many chemicals.

What is the root cause of your problem?

 

I just wrote a response and this thing erased it. Very upset right now.

 

Torpid, I feel torpid. I feel like action and feeling are not one. They are not working together. Sometimes I coldly do things but my feeling is not in it. I just do it coldly, mechanistically. Sometimes even in doing actions, like cleaning my room I have difficulty doing that, I don't know how to start, where to start, I can't finish, I frankly don't care if I finish, I feel REALLY, REALLY RETARDED, SLOW, etc. I was not like this in my early years, before 20. I don't know what the cause is exactly, just the effects.

 

I have fixed my forgetfulness and absentmindedness with Lions Mane, Cordyceps, Pregnenolone, DHEA, Magnesium Glycinate and Threonate, SAM-e, and B-right. However, I still feel slow like a person who is in a coma and walking around, zombie.

 

Anyhow, as far as hyperforin is concerned. I think it is an interesting compound. And it would be more interesting if we could have more of it in my opinion in a injectable form or a much higher amount that would not cause gastrointestinal disturbances.

 

 

Hyperforin btw, does downregulate the beta-1 andrenergic receptor so that may be why I did not feel it after the initial large amount trial. It is actually an agonist at that receptor but after exposure it is downregulated.

 

I am having trouble pasting abstracts on here. I had one that states that the dose is believed to be too low because of poor blood brain barrier crossing ability, http://www.ncbi.nlm....pubmed/20214594 


Edited by Valor5, 05 June 2015 - 07:37 PM.


#11 Valor5

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Posted 05 June 2015 - 07:52 PM

It appears that when one manipulates the blood brain barrier (BBB) that more drug/medicine can reach the brain. It seems like hyperforin and the other chemicals in St. Johns Wort have a tendency to hold things up at the "border". http://frontiersin.o.../event_abstract

 

This editor will not let me paste stuff.

 

 

 

 


Edited by Valor5, 05 June 2015 - 07:57 PM.


#12 Valor5

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Posted 05 June 2015 - 08:41 PM

It seems that the metabolic pathways of this compound may be hindering its efficacy, in the BBB and also the liver. I wonder if taking it with piperidine or quercetine would help with the blood brain barrier issue.

 

I wish I could find the patent for perika. It would be interesting if this company realized this problem of blood brain barrier permeability. I am wondering if they included piperidine or some other p-glycoprotein inhibitor. Actually that might not work.


Edited by Valor5, 05 June 2015 - 09:35 PM.


#13 Ark

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Posted 06 June 2015 - 12:20 AM

Consider adding Saffron extract, I like it more than SJW.

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#14 Valor5

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Posted 06 June 2015 - 01:06 PM

Consider adding Saffron extract, I like it more than SJW.

 

Yeah, that sounds like possibly a better alternative that doesn't have the permeability problem.

 

"Based on these data it can be assumed that the glycosylated crocines are not bioavailable after oral administration, but after intestinal deglycosylation the aglycon Crocetin should be absorbed to the systemic compartment and should also permeate the blood-brain-barrier" Planta Med 2013; 79 - PN55







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