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Two Mothers


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#1 Lazarus Long

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Posted 09 September 2005 - 03:30 AM


Here is an article in BBC about how they have approved a procedure that to me sounds basically one step away from cloning.

It is not cloning because what they are doing is transferring a newly fertilized nucleus to a second egg to bypass a mitochondrial disease but isn't this basically the same step as transferring nuclear material from other sources?

http://news.bbc.co.u...lth/4225564.stm

Embryo with two mothers approved 

The aim is to get healthy offspring free of inherited genetic disorders. UK scientists have won permission to create a human embryo that will have genetic material from two mothers. The Newcastle University team will transfer genetic material created when an egg and sperm fuse into another woman's egg.

The groundbreaking work aims to prevent mothers from passing certain genetic diseases on to their unborn babies.

Such diseases arise from DNA found outside the nucleus, and thus inherited separately from DNA in the nucleus.

They are collectively called mitochondrial diseases.


Studies in mice show it is possible to prevent the transmission of mitochondrial disease by moving the pronuclei - the genetic material which will go on to form a nucleus - from a fertilised egg containing bad mitochondria and putting it into another fertilised egg which only contains good mitochondria.

Professor Doug Turnbull, professor of neurology at Newcastle University, and Dr Mary Herbert, scientific director of Newcastle Fertility Centre at the city's Centre for Life, now plan to do the same in humans.

US scientists at the Institute for Reproductive Medicine and Science of St Barnabas, New Jersey, reported back in 2001 that they had successfully done similar, giving rise to 15 healthy children who appeared to be free of their mothers' disease.

Safety check

Instead of transplanting the pronuclei, these researchers injected another woman's ooplasm - the substance inside the cell that contains the mitochondrial DNA and bathes the nucleus - into the egg cell of the mother with faulty mitochondrial DNA.



#2 treonsverdery

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Posted 09 September 2005 - 04:28 AM

This is wonderful. combining this with studies of long lived mammals maternal mitochondria as well as the recent oocyte mass production research suggests that any lab animal or person is able to attain the highest longevity maternal mitochondria profile possible. that is have Jean Clement class longevists as your mom, whoever your nuclear DNA mom is.

Edited by treonsverdery, 02 November 2006 - 06:03 AM.


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#3 Infernity

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Posted 09 September 2005 - 11:21 AM

Two mothers?? Hmm it means it will have to be a female is it not?

And... what for? Lesbians? Or simply having the possibility to do that, as simply knowledge and option?

That's cool even though it's weired. It is a terrific claiming for all men who said there is no need in women because it is possible to multiply males or so without females, here is the female's claim, we can do the same.

-Infernity

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#4 Lazarus Long

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Posted 09 September 2005 - 11:56 AM

(Adi)
Two mothers?? Hmm it means it will have to be a female is it not?


No Adi it doesn't mean this at all. Did you read the article?

It has nothing to do with *parthenogenesis*.

The offspring are the result of normal fertilization between a male and female gametes and the odds for the resulting gender are unaffected. What is different is the mtDNA because they are switching the nuclei of two separate oocytes.




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