I tried it two days ago and I think it made me go "manic", I got super angry and depressed at the same time because one of our cats pissed on the carpet in a spare bedroom closet, the whole day went to shit because I could not pull it together. It was rediculous...
It warns people with bipolar disorder not to take it unless recommended by a doctor. I've been suspicious that I may be bipolar for awhile, I have these up times and down times,and have been trying to find the right supps/noops to help me but I have'nt found them/it yet.
The Sam-e made things worse for me.. I probably need to go see a doctor but it's hard to make that decision because I am fine alot of the time, but then I see heaven, and later find myself in hell..
I've tried effexor but that was years ago. I stopped taking it gradually and replaced it with illegal drugs.
I have not smoked my drug of choice (pot) for four months now and don't know if what I'm going through is from drugs (or lack therof) or if I have other psychological/physiological issues.. Time (and maybe a doctor visit) will tell..
I think it made me angry too. Inositol definitely caused anger in me. For the short time I used Sam-e it was definitely lifting my mood, but I was too anxious/high-strung. I am trying, without luck so far, to find something that helps me too.
I was on effexor, which helped a lot, for around ten years but finally quit like three months ago because I was sick of the side effects. The only time I was ever really manic (extremely manic actually) was when my effexor dose was too high, but on 75mg per day I did well, except for the side effects.
Theanine, Ashwaganda, Rhodiola, and Bacopa, all seem to make me more depressed. It's frustrating trying to find something that helps with depression/anxiety, when one has such an odd chemistry. If I don't find some relief soon, I will go to a doctor and try Cymbalta. It seems to be similar to effexor, but with lower incidence of side effects.