Hi,
I was reading about the connection between depression and changes in the hpa axis the other day. It is known, that depressed patients have changes in circadian curves of cortisol. There should be a spike in the morning, but depressed patients mostly have elevated baseline levels of cortisol and the spike is in the evening.
While it is known, that high cortisol levels over a long period are damaging to parts of the hippocampus and also slow down neurogenesis, I also read that tianeptine (I take it) protects the hippocampus against the changes. It has been shown that it does so even in presence of high levels of cortisol.
Now my question: Has anybody ever tried what happens taking cortisol or another glucocorticoid in the morning? I know it's damaging in the long term, but I'd like to know If this would work to be fit in the morning. My idea is basically similar to exogenous melatonin or agomelatin, but not resynchronizing the inner clock, but the hpa axis.
If anybodys has sources to these questions: It will be appreciated very much.
