5 replies to this topic

[dalack]

About three years ago my friend that was a professional pilot had an accident that did damage to Achilles tendon and surrounding muscle and cartilage of his left leg.

Even though he had surgery to repair it and has gone through extensive physical therapy he can't build up the strength needed to match his right leg when pressing down on the rudder pedal. The doctor said the muscle has atrophied and won't return to normal. 

My friend is in his 60's so i'm guessing this is one of the reasons that he can't make a full recovery. 

Does anyone think that Mk-677 could have the potential to help my friend regain enough strength in his left leg to become a pilot again? 

 

Thanks for your help and advice 

 

David

[zorba990]

Well this is what bpc157 is suposed to be good for (not verified it yet)
http://www.ncbi.nlm....pubmed/21030672

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.
Chang CH1, Tsai WC, Lin MS, Hsu YH, Pang JH.
Author information
Abstract
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.
PMID: 21030672 [PubMed - indexed for MEDLINE] Free full text

[niner]

What have they tried besides PT?  Creatine?  High protein diet? Anabolic Steroids?  I wonder if this is a case of a doctor writing him off as "an old person" who doesn't really need athleticism?   I don't think BPC 157 would be a first choice, since this is a muscle problem, not a tendon problem.   Sarcopenia (muscle loss) is caused by mitochondrial dysfunction.  You might want to try some c60 olive oil, perhaps include some MitoQ (both are mitochondrial antioxidants) as a way to improve mitochondrial function, halt further decline, and possibly assist marginal stem cells.  Get some carnitine on board too- 500mg ALCAR twice a day, possibly including a gram of L-carnitine would be a start there.  A balanced high-nutrient diet with supplemental protein, particularly Branched Chain Amino Acids is usually recommended.  Find a trainer with experience in rehabing patients with disuse atrophy.  Before trying MK-677, I'd want to make sure that the basics are covered, including supplemental testosterone if indicated.

[platypus]

What is his resistance training protocol? 

[dalack]

Thanks for all the information and the through responses. I'm going to talk with him and get an idea of what he's actually tried. I know for sure he hasn't tried creatine,  c60 or  L-carnitine. 

Do you think these alone could do the trick? I don't think his diet is high protein either. 

Again, thanks for all your help

 

David

[adamh]

Creatine for sure, mk677 would be worth a try too. It is not a steroid it merely stimulates your body's production of gh. I found a long time lingering problem in my elbow got better after a few months on it. Try .25mg per day for a couple months then lay off for a month then back on.