Neuroprotective Activity of Proproten in Rats with Experimental Local Photothrombosis of the Prefrontal Cortex.
[Article in English, Russian]
Romanova GA, Voronina TA, Dugina YL, Martyushev-Poklad AV, Sergeeva SA, Epstein OI, Barskov IV.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences; Institute of Pharmacology, Russian Academy of Medical Sciences; Research-and-Production Company "Materia Medica Holding"; Institute of Brain, Russian Academy of Medical Sciences, Moscow. nauka@materiamedica.ru.
Proproten (ultralow doses of antibodies to S100 protein) exhibited neuroprotective activity in rats with experimental photochemical thrombosis of the prefrontal cortex. Proproten was more potent than standard neuroprotectors piracetam and vinpocetine in alleviating the signs of memory disorders produced by ischemic injury. Pathomorphological study of the damaged area confirmed the neuroprotective effect of Proproten.
