2255 replies to this topic

[stefan_001]

NAD+ dependent SIRT3 in the news again:
Reduced SIRT3 contributes to large elastic artery stiffness with aging
http://www.fasebj.or...t/1080.13.short

[Nate-2004]

I'm 48 hours into a fast. Should I be taking NR? I haven't been taking any supplements other than occasional magnesium, sometimes l-theanine and sometimes ginger, but not sure about whether I should take anything at all. NR is considered a fasting mimetic, but what happens when you take NR while fasting? I doubt there's any research yet answering this question, but what are some hypothesis'?

Edited by Nate-2004, 16 May 2017 - 05:50 PM.

[MikeDC]

Guess depends how old you are. If you are less than 40, you probably don't need fasting and NR at the same time.

[Bryan_S]

The Effects of Nicotinamide Riboside Supplementation on NAD+/NADH Ratio and Bioenergetics

https://clinicaltria...how/NCT03151707

 

First received: May 4, 2017

Last updated: May 11, 2017

Last verified: May 2017

 

The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain NAD+/NADH ratio and bioenergetics functions in healthy individuals using phosphorus magnetic resonance spectroscopy (31P MRS) imaging.

 

The secondary aim is to investigate the effects of NR on brain structure and neurotransmitter functions using other neuroimaging methods.

 

More Human Clinical Trials https://www.ncbi.nlm...les/PMC5389020/

Edited by Bryan_S, 16 May 2017 - 11:11 PM.

[Bryan_S]

The brain, sirtuins, and ageing

 

Akiko Satoh, Shin-ichiro Imai & Leonard Guarente

 

Nature Reviews Neuroscience 18, 362–374 (2017) doi:10.1038/nrn.2017.42

Published online 18 May 2017

http://www.nature.co...ts_neuroscience

[Bryan_S]

Just a note guys, LongeCity would like to consolidate many of the NR threads into a Sub-forum so everything can be found in one area. This is all in the discussion phase right now.

 

If you see some changes to this thread don't be alarmed. We'll preserve this thread but it's getting to be rather long, and people are having problems finding the research they came here for. We might just start fresh with a new one.

 

Personally, I'd like to see a thread where we just see pure research of NAD-repletion and its related topics with the comments getting branched off into a parallel discussion thread. I'll discuss this with our LongeCity Admins and see if and how this can be arranged.

 

Bryan

 

As always JMHO