I would say, get off the stimulants & Wellbutrin altogether and try taking a decent nootropic stack, as well as an improvement in nutrition & physical activity, get bodywork or some type of therapy done to release stuck energies and chronic tensions (such as Rolfing, Reichian growth work, Body Stress Release, etc). Chronic, unreleased anger and/or tension can be a major cause of fatigue. Change all habitual ways of non-optimal operation of one's self, detoxify one's body, organize one's environment, complete unfinished goals. That would be a start. Of course, it would take a lot of motivation, but the way to full recovery is not a quick fix.
First of all, I know from experience that constant stimulant use wears a person out, physically and mentally. What a stimulant does is draw out all your energy stores and focus them in a very task-specific way, like a laser. After the effects wear off, it leaves the user very scattered, spacey and fatigued. Your friend is probably always 'coming down' from his frequent and long-term use of amphetamine-type substances.
The Wellbutrin is probably compounding the situation even further! It is a chemical called Bupropion, which is also marketed as a quit-smoking drug called Zyban. It affects the dopamine system of one's brain. From my experience with taking bupropion, it screws up one's concentration and short-term memory. I only took it for two weeks, and found that it totally affected my ability to keep my attention span focused. There are whole forums out there dedicated to the discussion of peoples' negative experiences with this stuff. I'd say get off it by tapering off the dosages, and then steer well clear of it.
Maybe your friend also has a sleeping problem as well, which greatly contributes to fatigue. I have sleeping problems, and I can sleep a whole night and still wake up in the morning feeling tired and shitty. So look into that possibility as well, and find a way to treat it. I am buying and trying a 'memory foam' mattress, which is a space-age material supposed to provide a feeling of weightless and refreshing sleep. he could also try an air purifier in his bedroom to clean out any dust and prevent breathing problems during sleep.
The nootropics I am going to use are:
Deprenyl - to alleviate depression and provide dopamine support
Phenibut - to alleviate anxiety and promote restful sleep (cycle the usage on and off every couple of weeks and watch your dosages, because tolerance can build up)
Piracetam, Aniracetam or Pramiracetam - to enhance mental focus and clarity
"Get Smart" from International Antiaging Systems (smart-drugs.net) - a good formula that combines many other nootropic and antidepressant properties.
There are many experts in this forum, experienced with nootropics, who could advise a good nootropic/antidepressant stack for your friend to take.
Please bear in mind that I am only providing my educated opinion. Also, take note of the possibility that ADD/ADHD is a fraud disease, and your friend can release himself from the stigma of having ADD; that he has the ability to change himself for the better and does not have to rely on the sickness industry for the rest of his life.
