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              Advocacy & Research for Unlimited Lifespans


External Counterpulsation (ECP) to Take Out the Garbage

external counterpulsation ecp dementia alzheimers autophagy circulation ejection fraction heart blood pressure

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#1 resveratrol_guy

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Posted 25 October 2015 - 04:20 AM

User tham mentioned back in 2013 that external counterpulsation (ECP) appeared to be a potent antidementia therapy with neither drugs nor surgery. But for some reason, perhaps relating to patentability, it remains outside the lexicon of most health professionals. This is doubly frustrating on account of its broad spectrum health effects beyond the brain. Now, billionaire Manoj Bhargava is doing something about it -- and so much more. The ECP discussion beings at 29:11, but the whole mindblowing documentary "Billions in Change" is highly recommended and immensely relevant to our current global circumstances.



#2 niner

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Posted 27 October 2015 - 01:37 AM

ECP is pretty cool.  Seems to be underutilized.  Here's a trial from 30 years ago...  (ECP is far and away the best part of that video.)

J Appl Physiol (1985). 2012 Mar;112(5):868-76. doi: 10.1152/japplphysiol.01336.2011. Epub 2011 Dec 22.
Enhanced external counterpulsation improves peripheral artery function and glucose tolerance in subjects with abnormal glucose tolerance.
Martin JS, Beck DT, Aranda JM Jr, Braith RW.


In coronary artery disease patients, enhanced external counterpulsation (EECP) improves peripheral arterial function and nitric oxide (NO) bioavailability, which have been implicated in the pathogenesis of abnormal glucose tolerance (AGT). We sought to evaluate the effects of EECP on outcomes of arterial function, glucose tolerance, and skeletal muscle morphology in subjects with AGT.

18 subjects with AGT were randomly (2:1 ratio) assigned to receive either 7 wk (35 1-h sessions) of EECP (n = 12) or 7 wk of standard care (control; n = 6). Peripheral vascular function, biochemical assays, glucose tolerance, and skeletal muscle morphology were evaluated before and after EECP or control. EECP increased normalized brachial artery (27%) and popliteal artery (52%) flow-mediated dilation. Plasma nitrite/nitrate (NOx) increased (30%) and 8-isoprostane-PGF-F(2α), a marker of lipid peroxidation in the plasma, decreased (-23%). Fasting plasma glucose declined (-16.9 ± 5.4 mg/dl), and the homeostasis model assessment of insulin resistance (HOMA-IR) decreased (31%) following EECP. Plasma glucose 120 min after initiation of oral glucose tolerance testing decreased (-28.3 ± 7.3 mg/dl), and the whole body composite insulin sensitivity index (C-ISI) increased (21%). VEGF concentrations increased (75%), and vastus lateralis skeletal muscle biopsies demonstrated improvements in capillary density following EECP. No change was observed in cellular signaling pathways, but there was a significant increase GLUT-4 protein expression (47%) following EECP.

Our findings provide novel evidence that EECP has a beneficial effect on peripheral arterial function and glucose tolerance in subjects with AGT.

PMID:  22194326   Free full text


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Also tagged with one or more of these keywords: external counterpulsation, ecp, dementia, alzheimers, autophagy, circulation, ejection fraction, heart, blood pressure

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