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At what point would you use BioViva (Gene Therapy)?

bioviva

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#1 Decimus

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Posted 31 October 2015 - 09:55 PM


I am sure most of you are aware of Liz Parrish and BioViva:

http://nextbigfuture...-antiaging.html

This obviously looks potentially promising, especially since it has shown efficacy in mice, but I am missing their "end game" where enough information has been gathered that members of the general public feel compelled to try it. It can't be screening for cancer. That would take decades and many subjects to get clarity on. It obviously can't be evidence of human life extension (again decades). Maybe they are looking for signs of telomere extension.

So what could BioViva or any other genes therapy company show you that would convince you to try it?

#2 Jay Jordan Hawke

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Posted 01 November 2015 - 02:36 PM

I've been following this, and like you, I was wondering what the end point is. I'm assuming they are measuring her telomeres to show they are lengthening. But until they release more info, I guess we won't know.



#3 sthira

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Posted 01 November 2015 - 07:09 PM

I think her team is measuring some metrics (eg, TAT, QTRAP, DNAm, gene expression changes...) as Parrish indicated in her Reddit "Ask Me Anything." If her injections show positive changes, then maybe her self-risk will result in clinical trials for more sick people. She's a self-experimenter like many here on this site are self-experimenters (see the C60 olive oil section). Parrish is her own n=1 pilot, and she's presumably being open and publicly candid about her experiences.

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#4 corb

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Posted 10 November 2015 - 04:14 PM

 

At what point would you use Gene Therapy

 

Telomerase therapy particularly only when and if it's proven to do something positive in humans.
 


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#5 Mind

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Posted 26 February 2018 - 07:45 PM

BioViva is partnering with Integrated health systems to offer treatments: https://www.integrat...ntact-1-section


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#6 recon

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Posted 05 March 2018 - 05:00 AM

I’d take this after a few more people took it.
Probably in a few more years.
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#7 Mind

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Posted 05 March 2018 - 08:14 PM

I would take it in a year or so, if a handful of people (maybe a dozen) who can afford the treatment go through with it with no side effects and show statistically significant improvement in several aging bio-markers. Also, right now, I hear the price tag is $20,000. That is too step for me. Under $10,000 would be more manageable for my finances.


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#8 Nate-2004

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Posted 06 March 2018 - 03:59 AM

Yeah $20k is steep as hell, way too steep to not wait until others with more money have seen fairly significant results. Like some significant reversal. At that point I'd probably save up as fast as I could and go for it. However, it'd have to be enough of a reversal / rejuvenation that I'll have actually gained back more years of youth than I spent waiting on results and saving up.


Edited by Nate-2004, 06 March 2018 - 04:00 AM.


#9 recon

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Posted 06 March 2018 - 05:22 AM

Then again, having overexpression of telomerase may take a decade or more to show visible physical changes since it should work to slow aging more effectively than to reverse it.
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#10 QuestforLife

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Posted 06 March 2018 - 09:46 AM

I think the 20k figure was a minimum for some unspecified gene therapy; as far as I'm aware the AAV HTERT gene therapy is significantly more, though I don't know why - is it that expensive to create the viral vector, anyone have information on this?

 

I think if they can demonstrate they can reach 50% of tissues in the body, and that gene expression is reset in those tissues to a more youthful level and/or telomere lengths are back to youthful lengths (not just in leucocytes) then I will be jumping on this. I don't know how long it would take to get that demanding level of evidence, but hopefully the Libella gene therapeutics trial this year, whom Bioviva are doing the biomarkers for, should give us an early indication of efficacy.


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