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Synthetic Resveratrol Emodin content???

reseratrol bulk resveratrol

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#1 TheFountain

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Posted 10 November 2015 - 11:28 PM


So, I got in touch with this bulk resveratrol supplier on ebay, great feedback, ordered other bulk items from them. They have a Synthetic (laboratory created) resveratrol for very cheap, 99.9% purity. 

 

Question is, what's the deal with synthetic resveratrol and emodin? Anybody know? 



#2 niner

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Posted 11 November 2015 - 12:34 AM

There shouldn't be any emodin in synthetic resveratrol.  That would require a completely different synthetic pathway.



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#3 TheFountain

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Posted 11 November 2015 - 06:12 AM

There shouldn't be any emodin in synthetic resveratrol.  That would require a completely different synthetic pathway.

The seller said his chemist told him that it's based on a plant derivative. I think the seller doesn't know much about the subject personally. Either way 25$ for 50 grams? Not too shabby. 



#4 pleiotropic

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Posted 11 November 2015 - 06:34 AM

Often when people say "their chemist" they just mean the lab in China they bought it from.

 

Powdercity sell 99% resveratrol 50g for $22.60 (less 10% if you use the FEDORA coupon) and can supply a US lab CoA.  That's where I got mine from.



#5 TheFountain

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Posted 11 November 2015 - 06:56 AM

Often when people say "their chemist" they just mean the lab in China they bought it from.

 

Powdercity sell 99% resveratrol 50g for $22.60 (less 10% if you use the FEDORA coupon) and can supply a US lab CoA.  That's where I got mine from.

That's the brand I am referring to, Powder city. I can get 3$ off with the fedora coupon? On ebay it's about 25$ free shipping.

 

What have you to say about the quality? 



#6 pleiotropic

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Posted 11 November 2015 - 10:31 AM

Good service.  Peace of mind knowing they do independent testing (not just manufacturer CoA).  It was shipped promptly.   It's a white powder in a sealed, labelled foil bag.

 

I also bought theobromine, glycine and citrulline.  They all check as expected out too.



#7 maxwatt

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Posted 11 November 2015 - 11:32 AM

What is referred to as "synthetic" resveratrol, is not the product of chemical synthesis, but brewed in a vat of genetically modified yeast that has been engineered to produce resveratrol as a metabolic product..  No emodin.  The first few batches had unidentified impurities, but what has been coming out since is of good quality.  If you PM me the name of the supplier, I may be able to tell you more about him.


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#8 geo12the

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Posted 11 November 2015 - 06:26 PM

This is the stuff I take:

 

http://www.nutraingr...r-safety-purity

 

http://www.dsm.com/m...ls/resvida.html

 

My impression was that this particular composition was chemically produced without fermentation, there are some patents out there that discuss it.

 

My husband and I were having many many many serious tendon and joint issues when we were taking purified resveratrol from knotweed, even stuff that was supposed to be ultra pure. The tendon issues evaporated soon after we switched to resvida. 

 

 


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#9 TheFountain

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Posted 12 November 2015 - 01:01 AM

Good service.  Peace of mind knowing they do independent testing (not just manufacturer CoA).  It was shipped promptly.   It's a white powder in a sealed, labelled foil bag.

 

I also bought theobromine, glycine and citrulline.  They all check as expected out too.

I ordered their L-theanine and ALCAR so far. 

 

Next it's the resveratrol. Man, 50 grams for 25$? Holy cow!


What is referred to as "synthetic" resveratrol, is not the product of chemical synthesis, but brewed in a vat of genetically modified yeast that has been engineered to produce resveratrol as a metabolic product..  No emodin.  The first few batches had unidentified impurities, but what has been coming out since is of good quality.  If you PM me the name of the supplier, I may be able to tell you more about him.

Well. it's already been mentioned in the thread. Feel free to tell me more!


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#10 maxwatt

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Posted 12 November 2015 - 02:58 AM

Oh, yes.  Powder City.  They buy from the network of Chinese extract and pharmaceutical suppliers from Chongqing to Suzhou.

 

Certificate of merit:  http://www.fda.gov/I.../ucm444410.htm 

 

 

 

 


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#11 pleiotropic

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Posted 12 November 2015 - 03:23 AM

Oh, yes.  Powder City.  They buy from the network of Chinese extract and pharmaceutical suppliers from Chongqing to Suzhou.

 

Certificate of merit:  http://www.fda.gov/I.../ucm444410.htm 

 

As do most of supplement companies?  Even the giants like NOW Foods, Swanson, Vitacost, Doctors Best, Source Naturals and so on.   China is very cost effective.

 

The difference I find is that very few companies bother to have the stuff tested before reselling it.  For example, where as NOW Foods have their own in-house lab and staff of trained chemists doing QA on all raw materials, I've found that for some products Swanson relies on Chinese and Indian manufactuer CoAs.  

 

PowderCity have every batch tested after they receive it from their suppliers and before it goes on sale.  They use Colmaric Analyticals (located in Tennessee) to obtain purity, bacterial count and heavy metal testing.  I've requested a few original certificates of analysis from them and it checks out as far as batch numbers matching the products I've received.  

 

 

I'm not sure what your point is with that FDA link.  Many supplement companies were sent a notice advising that AMP Citrate was not being recognised by the FDA as a dietary supplement (i.e. not something found in the human diet or herbal or derived there-of).  AMP Citrate was a popular preworkout ingredient that replaced DMAA after sites and preworkout products started to withdraw it from sale for the same reason.  Powdercity sold independently tested AMP Citrate and then ceased selling it.

 

Also, I won't name names but I've seen a few supplement/nootropic companies/ebay sellers mentioned on longecity that also source from China but do not have an open and honest practice of testing before on-selling, saying "trust me, it's pure, I tried it" or saying "trust me, no one has complained" or "we are experts, trust us" etc.  

 

Each to their own, but I think people should be more careful.

 

 


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#12 TheFountain

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Posted 12 November 2015 - 05:36 AM

 

Oh, yes.  Powder City.  They buy from the network of Chinese extract and pharmaceutical suppliers from Chongqing to Suzhou.

 

Certificate of merit:  http://www.fda.gov/I.../ucm444410.htm 

 

As do most of supplement companies?  Even the giants like NOW Foods, Swanson, Vitacost, Doctors Best, Source Naturals and so on.   China is very cost effective.

 

The difference I find is that very few companies bother to have the stuff tested before reselling it.  For example, where as NOW Foods have their own in-house lab and staff of trained chemists doing QA on all raw materials, I've found that for some products Swanson relies on Chinese and Indian manufactuer CoAs.  

 

PowderCity have every batch tested after they receive it from their suppliers and before it goes on sale.  They use Colmaric Analyticals (located in Tennessee) to obtain purity, bacterial count and heavy metal testing.  I've requested a few original certificates of analysis from them and it checks out as far as batch numbers matching the products I've received.  

 

 

I'm not sure what your point is with that FDA link.  Many supplement companies were sent a notice advising that AMP Citrate was not being recognised by the FDA as a dietary supplement (i.e. not something found in the human diet or herbal or derived there-of).  AMP Citrate was a popular preworkout ingredient that replaced DMAA after sites and preworkout products started to withdraw it from sale for the same reason.  Powdercity sold independently tested AMP Citrate and then ceased selling it.

 

Also, I won't name names but I've seen a few supplement/nootropic companies/ebay sellers mentioned on longecity that also source from China but do not have an open and honest practice of testing before on-selling, saying "trust me, it's pure, I tried it" or saying "trust me, no one has complained" or "we are experts, trust us" etc.  

 

Each to their own, but I think people should be more careful.

 

How do I request certificate of analysis? Who do i go to? I'd like to read them. 



#13 pleiotropic

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Posted 12 November 2015 - 07:44 AM

Just use the contact option on the powdercity website and they'll email a PDF.


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#14 TheFountain

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Posted 13 November 2015 - 09:04 PM

pleiotropic
How do you take this resveratrol?

 


I just ordered the 50 gram batch. Is mixing it with water in the beginning of the day a good idea? Possibly 30 minutes prior to meal? 

 

I always take my resveratrol this way because of the idea of re-starting the biological signalling process at the beginning of the day. 



#15 maxwatt

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Posted 14 November 2015 - 04:12 AM

pleiotropic

How do you take this resveratrol?
 

 


I just ordered the 50 gram batch. Is mixing it with water in the beginning of the day a good idea? Possibly 30 minutes prior to meal? 

 

I always take my resveratrol this way because of the idea of re-starting the biological signalling process at the beginning of the day. 

 

 

It's not water-soluble.  Just put the powder under your tongue and have a drink to wash it down.  Sublingual absorption is low without alcohol, but you'd not be wanting to drink that early. 


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#16 TheFountain

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Posted 16 November 2015 - 09:41 PM

 

pleiotropic

How do you take this resveratrol?
 

 


I just ordered the 50 gram batch. Is mixing it with water in the beginning of the day a good idea? Possibly 30 minutes prior to meal? 

 

I always take my resveratrol this way because of the idea of re-starting the biological signalling process at the beginning of the day. 

 

 

It's not water-soluble.  Just put the powder under your tongue and have a drink to wash it down.  Sublingual absorption is low without alcohol, but you'd not be wanting to drink that early. 

 

How about with a spoon of olive oil? 



#17 maxwatt

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Posted 17 November 2015 - 12:15 PM

 


How about with a spoon of olive oil? 

 

It's not that soluble in oil, either.  Ethanol works.  Some people use vodka.  Interestingly, this results in sublingual aborption right into the bloodstream.  The superior absorption versus possible long term effects of alcohol on the oral tissues (possible cancer) need to be considered, and starting the day with a shot of vodka might not be a good idea. 

 

WRT morning versus evening dosage, both seem to work.  The effect on circadian rhythms is different depending on when it is taken according to one study.  It's possible to use both morning and night.  Noon has not been studied in this regard, as far as I know.



#18 TheFountain

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Posted 17 November 2015 - 09:48 PM

 

 


How about with a spoon of olive oil? 

 

It's not that soluble in oil, either.  Ethanol works.  Some people use vodka.  Interestingly, this results in sublingual aborption right into the bloodstream.  The superior absorption versus possible long term effects of alcohol on the oral tissues (possible cancer) need to be considered, and starting the day with a shot of vodka might not be a good idea. 

 

WRT morning versus evening dosage, both seem to work.  The effect on circadian rhythms is different depending on when it is taken according to one study.  It's possible to use both morning and night.  Noon has not been studied in this regard, as far as I know.

 

I said olive oil because I remember the discussion about fat as a potential delivery mechanism for resveratrol or other supplements. 



#19 maxwatt

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Posted 18 November 2015 - 04:08 AM

We used to think olive oil would help delivery, making it soluble in the gut.  Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats.  And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less.    I take mine before breakfast on rising, or before bed with only water as a chaser.  Well, sometimes bourbon at night.  And a number of other things.



#20 TheFountain

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Posted 18 November 2015 - 09:16 PM

We used to think olive oil would help delivery, making it soluble in the gut.  Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats.  And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less.    I take mine before breakfast on rising, or before bed with only water as a chaser.  Well, sometimes bourbon at night.  And a number of other things.

Yea that's what I am doing, taking it in the morning with nothing in the stomach, taking my shower and THEN eating breakfast. 

 

I wonder how mixing one of these scoops in with a glass of red wine at night would change efficacy if at all?



#21 maxwatt

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Posted 18 November 2015 - 09:39 PM

 

We used to think olive oil would help delivery, making it soluble in the gut.  Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats.  And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less.    I take mine before breakfast on rising, or before bed with only water as a chaser.  Well, sometimes bourbon at night.  And a number of other things.

Yea that's what I am doing, taking it in the morning with nothing in the stomach, taking my shower and THEN eating breakfast. 

 

I wonder how mixing one of these scoops in with a glass of red wine at night would change efficacy if at all?

 

 

One way to ruin a glass of red wine. 

 

Wine is typically 11 or 12% ethanol, sometimes as much as 15% with some of the semi-premium California and Australian reds.  The higher the percentage of alcohol. the more resveratrol will dissolve per unit volume.  Whiskies are typically 40%, some votkas 45 or 50%.  You can get Everclear which is 90%, in some states.  Some here have reported doing that, but other than reporting a "rush" which could as well be due the to the alcohol being absorbed in the mouth directly to the blood, rather than to resveratrol.  Nor have such users reported any better results than with other modes of adminisration.



#22 zorba990

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Posted 18 November 2015 - 09:55 PM

We used to think olive oil would help delivery, making it soluble in the gut. Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats. And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less. I take mine before breakfast on rising, or before bed with only water as a chaser. Well, sometimes bourbon at night. And a number of other things.


I found, recently, that mixing mine with fish oil I can take one gram without needing sodium butyrate to avoid diahhrea.
I mix fish oils, mega resveratrol micronized res, and koncentrated k with Nordic naturals fish oil. I plan to add omega 7 soon.

#23 maxwatt

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Posted 19 November 2015 - 03:42 PM

 

We used to think olive oil would help delivery, making it soluble in the gut. Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats. And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less. I take mine before breakfast on rising, or before bed with only water as a chaser. Well, sometimes bourbon at night. And a number of other things.


I found, recently, that mixing mine with fish oil I can take one gram without needing sodium butyrate to avoid diahhrea.
I mix fish oils, mega resveratrol micronized res, and koncentrated k with Nordic naturals fish oil. I plan to add omega 7 soon.

 

 

If you aren't getting diarrhea, how do you know that absorption into your bloodstream is not also blocked?
 



#24 TheFountain

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Posted 20 November 2015 - 08:19 PM

 

 

We used to think olive oil would help delivery, making it soluble in the gut.  Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats.  And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less.    I take mine before breakfast on rising, or before bed with only water as a chaser.  Well, sometimes bourbon at night.  And a number of other things.

Yea that's what I am doing, taking it in the morning with nothing in the stomach, taking my shower and THEN eating breakfast. 

 

I wonder how mixing one of these scoops in with a glass of red wine at night would change efficacy if at all?

 

 

One way to ruin a glass of red wine. 

 

Wine is typically 11 or 12% ethanol, sometimes as much as 15% with some of the semi-premium California and Australian reds.  The higher the percentage of alcohol. the more resveratrol will dissolve per unit volume.  Whiskies are typically 40%, some votkas 45 or 50%.  You can get Everclear which is 90%, in some states.  Some here have reported doing that, but other than reporting a "rush" which could as well be due the to the alcohol being absorbed in the mouth directly to the blood, rather than to resveratrol.  Nor have such users reported any better results than with other modes of adminisration.

 

Okay so, I let the resveratrol dissolve sublingually then I sip some wine? I think I might be able to do that. I just hope it doesn't keep me up at night. 

 

As far as hard liquor with higher ethanol content. Yuck! Hard liquor makes my belly ache. 



#25 gizmobrain

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Posted 23 November 2015 - 09:36 PM

Traditional resveratrol has been the source of tendon/muscle pains for me (mostly slowed healing of damage following working out). Synthetic resveratrol in the form of Resvida does not seem to have these effects.

I'd love to get my hands on some bulk of this, but the company that makes it seems to want me to be in the food industry to get my hands on some...  :dry:  Bricker Labs now sells it in capsule form, but I'd rather buy it in bulk.

 

Anyone got any connections? Anyone able to compare Resvida to the chinese sourced substance mentioned above?



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#26 zorba990

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Posted 23 November 2015 - 10:41 PM

We used to think olive oil would help delivery, making it soluble in the gut. Then we saw the pharmokinetic studies; to our surprise, it found its way into the blood stream more quickly, and with a higher concentration, when taken without food or fats. And at doses greater than a gram taken orally, absorption became less efficient, and the peak level and area under the curve was less. I take mine before breakfast on rising, or before bed with only water as a chaser. Well, sometimes bourbon at night. And a number of other things.

I found, recently, that mixing mine with fish oil I can take one gram without needing sodium butyrate to avoid diahhrea.
I mix fish oils, mega resveratrol micronized res, and koncentrated k with Nordic naturals fish oil. I plan to add omega 7 soon.

If you aren't getting diarrhea, how do you know that absorption into your bloodstream is not also blocked?

I guess I cannot easily determine that. But I haven't seemed to pass any indigestible material or any change that would make me think it's not absorbed along with the fish oil and vitamin k.




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