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Constant Heavy Drunk/Drugged/Sedated Brain with Dimmed vision and Anhedonia

brainfog dimmed vision anhedonia

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#31 ceridwen

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Posted 24 November 2015 - 02:07 PM

I have had similar results so recently decided to treat my cognitive decline as if it were Lyme. I have been getting some results.
The 1st thing to do is break up any Biofilms that might be there. While the Biofilms are there nothing that one takes works. There are several medicines that can break up Biofilms xylitol, Wobenzyme,TinidazoleJ,Nepron,Morninga Oleifera,Mild Hyperbaric Oxygen, Hanitaki Fruit.
Try these before going to mop up the things that are released from the Biofilm. Bentonite clay should attach to pathogens and drag them out of the body. I am also trying anything I can to make my brain grow Montelukast,Hydergine,Noopept,Folate.
So far for removing Biofilm I have tried Xylitol and Wobenzyme I intend getting the other supplements but Hyperbaric Oxygen costs too much for me to try right now.
Nothing will work until the Biofilm is removed.
Hope this helps

#32 Sephrioth

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Posted 24 November 2015 - 02:46 PM

I have had similar results so recently decided to treat my cognitive decline as if it were Lyme. I have been getting some results.
The 1st thing to do is break up any Biofilms that might be there. While the Biofilms are there nothing that one takes works. There are several medicines that can break up Biofilms xylitol, Wobenzyme,TinidazoleJ,Nepron,Morninga Oleifera,Mild Hyperbaric Oxygen, Hanitaki Fruit.
Try these before going to mop up the things that are released from the Biofilm. Bentonite clay should attach to pathogens and drag them out of the body. I am also trying anything I can to make my brain grow Montelukast,Hydergine,Noopept,Folate.
So far for removing Biofilm I have tried Xylitol and Wobenzyme I intend getting the other supplements but Hyperbaric Oxygen costs too much for me to try right now.
Nothing will work until the Biofilm is removed.
Hope this helps

 

Thanks, I didn't really know that. I will look into it. The problem is crossing the Blood Brain Barrier of course. 


Edited by Sephrioth, 24 November 2015 - 02:47 PM.


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#33 PalmAnita

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Posted 27 December 2015 - 11:06 AM

This is somewhat beyond my current knowledge, but two points that came to my mind:

 

- Blood flow and oxygen. With a heart rate this low, and the platelet issues on top of that, is there a possibility for the brain getting too little oxygen overall? Then myo-inositol trispyrophosphate could help tremendously.

 

- Hypoactive glutamate. Glutamate is the main excitatory transmitter in the brain, it's responsible for just everything and if there's something wrong here, then the dopaminergics (Ritalin etc.) will only work partially, as you've experienced it. The glutamate system is currently being researched extensively, and most people seem to have rather imbalances (especially overactive NMDA receptors due to stress, but what you describe could well be underactive NMDA- because this dimmed vision, brain fog, lack of emotions and all that sounds really close to what one might experience on a too high dose of a NMDA antagonist! They also pixelate the vision and can make it look cartoon-ish from time to time due to impaired processing of sensory input which happens through NMDA). There are a few things that activate NMDA, but as my research has mainly been how to -de-activate it, I hope others can help out. I know of sarcosine for example. And we have the AMPA positive modulators, unifiram and sunifiram. The latter is more stimulating, maybe you want to give it a try.

 

Also, the yellow-brown-ish coloring of the vision reminds me of something. Have to search for it, but I think it could have been sildenafil (Viagra). Vasodilation, nitric oxide. The brain trying to get more oxygen? 


Edited by dopamimetiq, 27 December 2015 - 11:18 AM.

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#34 ceridwen

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Posted 27 December 2015 - 12:13 PM

Where can I get myo-inositol trispyrophosphate?

#35 Sephrioth

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Posted 27 December 2015 - 12:52 PM

This is somewhat beyond my current knowledge, but two points that came to my mind:

 

- Blood flow and oxygen. With a heart rate this low, and the platelet issues on top of that, is there a possibility for the brain getting too little oxygen overall? Then myo-inositol trispyrophosphate could help tremendously.

 

- Hypoactive glutamate. Glutamate is the main excitatory transmitter in the brain, it's responsible for just everything and if there's something wrong here, then the dopaminergics (Ritalin etc.) will only work partially, as you've experienced it. The glutamate system is currently being researched extensively, and most people seem to have rather imbalances (especially overactive NMDA receptors due to stress, but what you describe could well be underactive NMDA- because this dimmed vision, brain fog, lack of emotions and all that sounds really close to what one might experience on a too high dose of a NMDA antagonist! They also pixelate the vision and can make it look cartoon-ish from time to time due to impaired processing of sensory input which happens through NMDA). There are a few things that activate NMDA, but as my research has mainly been how to -de-activate it, I hope others can help out. I know of sarcosine for example. And we have the AMPA positive modulators, unifiram and sunifiram. The latter is more stimulating, maybe you want to give it a try.

 

Also, the yellow-brown-ish coloring of the vision reminds me of something. Have to search for it, but I think it could have been sildenafil (Viagra). Vasodilation, nitric oxide. The brain trying to get more oxygen? 

 

Thanks! that is very interesting. I was thinking in the same direction myself. Under-active NADA and maybe overactive GABA. (Combined with possible dopamine receptor down regulation and physical brain damage due to lowered neurosteroid protection).

 

Oxygen deprivation could certainly play a part too. I do not feel better or worse however when I raise my heart rate by exercising. When I stand/walk around, my heart rate also returns to 60, without any improvement. I did however have a few incidents where I wasn't getting enough oxygen at night (due to deviated septum), and dreamt I was suffocating without being able to wake up. After that I felt horrible for months (physical sedated feeling in my forehead like a local anesthetic sedation). When that feeling slowly disappated, my underlying symptoms were much worse. I have had two of those episodes a year apart. Since then I use nasal spray and nasal clamp, and I sleep upright. I have never had that heavy acute anesthetic feeling since. 

 

I am also thinking about chronic inflammation in my brain, since I have periods where I become much worse (feeling physically very ill in my head) without a clear cause. Sometimes I have a few weeks of improvement where I feel 65-70% sedated/drugged. (I mean 65% ill where 100% would be an almost complete comatose state and horrible ill feeling (and 0% quality of life). But then I fall back again, feeling 75% ill, 85% ill and ending up suffering non stop and feeling 95% ill (Not even able to watch TV or a movie).

 

The dimmed dark, yellow vision is much worse when the other brain-symptoms also become worse. Early in the morning and later at night when my brain is the most tired it gets worse too. 


Edited by Sephrioth, 27 December 2015 - 12:54 PM.


#36 Sephrioth

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Posted 27 December 2015 - 01:03 PM

I also want to say that these vision problems are not subtle. They get to absolutely horrible levels at times. Everything looks almost grotesk, strange discolored, dimmed, yellow. I can't describe it. If I could let someone else look through my eyes they would be utterly shocked. The combination with the ill, drugged feeling and the dimmed, dark yellow vision is almost unbearable.



#37 vader

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Posted 27 December 2015 - 03:05 PM

I also want to say that these vision problems are not subtle. They get to absolutely horrible levels at times. Everything looks almost grotesk, strange discolored, dimmed, yellow. I can't describe it. If I could let someone else look through my eyes they would be utterly shocked. The combination with the ill, drugged feeling and the dimmed, dark yellow vision is almost unbearable.

 

This sounds like derealization or HPPD. I bet your cortisol is sky time high and you are suffering PTSD or something. Unfortunately those kinds of disorders are very hard to treat by drugs or psychotherapy. It is in a sense an ego death, in ancient times you would probably be some kind of shaman but today this disorder makes life unbearable.

 

I wouldn't discount the idea that someone in your close proximity is making your life stressful. Could be some kind of conversion disorder.

 

Of course it could be even as simple as sinus infection going into vagus nerve an causing it all, but it is a stretch.

 

I would start treatment with giving up all drugs and recreational substances (including alcohol, nicotine, benzos, weed and caffeine), no supplements, clean diet with most starch and some vegge. Then would compound this with light exercise and see from there. 

 

I am sympathizing because im suffering very similar problems without resolution.

 

Btw, viagra causes blue tinted vision, possibly depression can cause tinted vision too (if Picasso's blue period is to be believed :P).


Edited by vader, 27 December 2015 - 03:13 PM.

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#38 Sephrioth

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Posted 27 December 2015 - 05:14 PM

 

I also want to say that these vision problems are not subtle. They get to absolutely horrible levels at times. Everything looks almost grotesk, strange discolored, dimmed, yellow. I can't describe it. If I could let someone else look through my eyes they would be utterly shocked. The combination with the ill, drugged feeling and the dimmed, dark yellow vision is almost unbearable.

 

This sounds like derealization or HPPD. I bet your cortisol is sky time high and you are suffering PTSD or something. Unfortunately those kinds of disorders are very hard to treat by drugs or psychotherapy. It is in a sense an ego death, in ancient times you would probably be some kind of shaman but today this disorder makes life unbearable.

 

I wouldn't discount the idea that someone in your close proximity is making your life stressful. Could be some kind of conversion disorder.

 

Of course it could be even as simple as sinus infection going into vagus nerve an causing it all, but it is a stretch.

 

I would start treatment with giving up all drugs and recreational substances (including alcohol, nicotine, benzos, weed and caffeine), no supplements, clean diet with most starch and some vegge. Then would compound this with light exercise and see from there. 

 

I am sympathizing because im suffering very similar problems without resolution.

 

Btw, viagra causes blue tinted vision, possibly depression can cause tinted vision too (if Picasso's blue period is to be believed :P).

 

 

Sorry, but this is absolutely not my problem!! It is very hard for me to describe what I see, and how I feel. That is why people keep interpreting my symptoms in the wrong way and projecting their own experiences with anxiety. I do not have anxiety. I do not have a depersonalisation, derealization disorder or any of the symptoms of those conditions.

 

It makes no sense whatsoever in my case. I have no stress, other than that caused by this illness. I want to do nothing more, than to be able to create again. I just want to feel a little bit better, that is all. I do not even care if I feel bad, just good enough to work, and not suffer unbearably. When I feel a little bit better, all I do is work. Why would I sabotage myself??? Feeling unbearably ill all the time, unable to even watch TV, or a movie, let alone read. I am immensely relieved if I feel a little bit better (20-25% improvement at the most) for a few weeks, but it never lasts.

 

I have always exercised (currently 10x a day for 5 minutes) But I used to do 4x 15 minutes etc. Cardio, weights etc. I eat as healthy as anyone can possible eat (all raw and cooked vegetables, some sardines, no carbohydrates sugars). I never used drugs, or alcohol or smoked in my entire life. I have always lived and eaten healthy. I already wrote that multiple times. 

 

Please, please stop telling me it is anxiety. I really wish it was, but it isn't. 


Edited by Sephrioth, 27 December 2015 - 05:23 PM.


#39 vader

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Posted 27 December 2015 - 05:30 PM

 

 

I also want to say that these vision problems are not subtle. They get to absolutely horrible levels at times. Everything looks almost grotesk, strange discolored, dimmed, yellow. I can't describe it. If I could let someone else look through my eyes they would be utterly shocked. The combination with the ill, drugged feeling and the dimmed, dark yellow vision is almost unbearable.

 

This sounds like derealization or HPPD. I bet your cortisol is sky time high and you are suffering PTSD or something. Unfortunately those kinds of disorders are very hard to treat by drugs or psychotherapy. It is in a sense an ego death, in ancient times you would probably be some kind of shaman but today this disorder makes life unbearable.

 

I wouldn't discount the idea that someone in your close proximity is making your life stressful. Could be some kind of conversion disorder.

 

Of course it could be even as simple as sinus infection going into vagus nerve an causing it all, but it is a stretch.

 

I would start treatment with giving up all drugs and recreational substances (including alcohol, nicotine, benzos, weed and caffeine), no supplements, clean diet with most starch and some vegge. Then would compound this with light exercise and see from there. 

 

I am sympathizing because im suffering very similar problems without resolution.

 

Btw, viagra causes blue tinted vision, possibly depression can cause tinted vision too (if Picasso's blue period is to be believed :P).

 

 

Sorry, but this is absolutely not my problem!! It is very hard for me to describe what I see, and how I feel. That is why people keep interpreting my symptoms in the wrong way and projecting their own experiences with anxiety. I do not have anxiety. I do not have a depersonalisation, derealization disorder or any of the symptoms of those conditions.

 

It makes no sense whatsoever in my case. I have no stress, other than that caused by this illness. I want to do nothing more, than to be able to create again. I just want to feel a little bit better, that is all. I do not even care if I feel bad, just good enough to work, and not suffer unbearably. When I feel a little bit better, all I do is work. Why would I sabotage myself??? Feeling unbearably ill all the time, unable to even watch TV, or a movie, let alone read. I am immensely relieved if I feel a little bit better (20-25% improvement at the most) for a few weeks, but it never lasts.

 

Please, please stop telling me it is anxiety. I really wish it was, but it isn't. 

 

 

That is the point of depersonalization / derealization. All people have such moments, but if you get dissociative disorder then the stress fuels itself until it becomes relentless. In such a feedback loop even the smallest tingle or skipped heartbeat is interpreted by the body as a life threatening situation. You might as well have a disease so mysterious as Gulf War Syndrome, but it doesn't mean that treatment can't be made based on symptoms. I would try a short course of benzos.


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#40 Sephrioth

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Posted 27 December 2015 - 06:48 PM

That is the point of depersonalization / derealization. All people have such moments, but if you get dissociative disorder then the stress fuels itself until it becomes relentless. In such a feedback loop even the smallest tingle or skipped heartbeat is interpreted by the body as a life threatening situation. You might as well have a disease so mysterious as Gulf War Syndrome, but it doesn't mean that treatment can't be made based on symptoms. I would try a short course of benzos.

 

I do not have any of the symptoms of a dissociative disease. I have read about them extensively years ago, because I have researched every possible condition. Please read my original post. I don't know how I can convince anyone that it's not psychological. They would have to experience first hand how I feel. It's so easy for someone who has not gone through my symptoms to project their own experience or to judge. This is a physical sensation (almost like the flue) and the vision symptoms are not like those of derealisation or depersonalization. I just can't put into words what it looks like. A heartbeat of 30, second degree hart block and aplastic anemia is psychological too? Hormones all wrong, psychological or anxiety of course! I feel non-stop horrible without anxiety, quite the opposite actually. Then blame it on suppressed anxiety or depression, why not? I get really, really fed up with this, sorry. I know everyone means well, but it gets very frustrating if it isn't true.



#41 PalmAnita

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Posted 27 December 2015 - 08:52 PM

Where can I get myo-inositol trispyrophosphate?

 

Think nyles7.com has it. He's also on eBay and one of the few really trustable private vendors (at least of those I know of), has been around for years, and I've bought from him repeatedly.



#42 pheanix997

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Posted 03 February 2016 - 11:55 PM

I believe OP has depression but doesn't realize it. Life-long, long-term depression is always, always unconscious. It's like a fish in water - it's all you've ever known.

Depression impairs vision. I can't post a link now but I think I read on wikipedia that depression causes a greyness, dullness, yuckiness to your vision. Just look at the subtly "disgusted with life" look on a depressed person's face and you can almost SEE through their own POV looking out at a dim, barren wolrd. I can attest to this - SSRI's brighten up my vision.

HOWEVER, I do think you also have neuro problems. I have the same vision issues but mine is more a lack of crispness/ clarity/ depth perception than what you're experiencing. Stimilant medication for my ADD often gives me HD-like vision, and also anything that juices up the brain, which tells me for me its neurological and not psychological.

When I had this vision impairment, I too could not explain it. I would look at something but there would be a lag in processing it. It's very, very hard to explain. I'm on my first week trial of NSI-189 and I've never in my entire life had as crisp, sharp vision as I do now - but its too soon to say for sure if itll last.

These issues, regardless of what causes them, also make one read more to find out, constsntly researching on a computer, refraining from using the eyes for long-distance cause you're so preoccuoied with your problems, and it gets worse. Dry eye, eye strain, worsening amblyopia, etc.

My vision has gotten worse from this constant reading but I don't regret it cause I've discovered now its not in my head and it's a brain thing %110.

Now what caused my neuro problems is another issue. Stress/ anxiety /depression / ADHD/ Sensory processing / poor posture leading to poorer vision/ concussions from hockey, etc.etc. probably all have. But like I said Stimulant medication and NSI-189 has helped ALOT.

I'm astounded at the vast amount of things you have tried that haven't given relief... i'm sorry I can't help more. I do think deprssion is one of your issues because vision issues alone wouldn't necessarily cause your anheadonia and deprssion, e.g. my boss has BAD Strabismus and convergence insufficiency where he literally sees double 24/7... and he's happy as hell and doesn't complain about it. My opthamologist had the same issue and also cant read but hes an alpha male son of a bitch. Those problems would depress me SO much and I would probably start tracing all my problems to that issue!
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#43 Sephrioth

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Posted 04 February 2016 - 05:33 AM

Thank you for your answer but I have already explained I do not have stress, anxiety or anything like that. I also really do not have a depression. Please read my original post and reactions carefully. This is physical, either caused by damage, hormonal/neurotransmitter dis-regulation or persistent infection. 



#44 pheanix997

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Posted 04 February 2016 - 09:12 AM

Thank you for your answer but I have already explained I do not have stress, anxiety or anything like that. I also really do not have a depression. Please read my original post and reactions carefully. This is physical, either caused by damage, hormonal/neurotransmitter dis-regulation or persistent infection. 

I still think depression is at least part of the picture. 

 

But your physical symptoms are probably real. I know because I have them too. I'm spatially disoriented, off-balance, have vision issues as well, etc. It's really, really impairing. And although I have depression and anxiety, it is frustrating when people chalk it up to JUST that. I think a lot of my issues stems from being born with ADD and with a family history of Alzheimer's, having lifelong stress and mild dysthymia causing damage, and then the many, many mild concussions I sustained over my hockey career. It's all cumulative. I know the feeling of being sedated/ drunk. In fact I started a thread about just this feeling a while back, you can look through it. I think being on an SSRI has contributed to it, but these problems go back much before I ever hopped on an anti-depressant. 

 

Anyway, I can't remember if you said you'd tried antidepressants? If I recall it seemed like that's the only thing you haven't tried. Wouldn't hurt to try... Edit: I looked and it seems you haven't tried any. I'm on wellbutrin and it helps a lot with this. I think you're past the realm of supplemental help and need to start trying pharmaceuticals, which will bring you closer to baseline where supplements would bring more improvements. 

 

If you find anything that helps please come back to update the thread because I'm in the same boat! Good luck! 


Edited by pheanix997, 04 February 2016 - 09:18 AM.

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#45 NG_F

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Posted 04 February 2016 - 09:15 AM

Do you notice, see or feel your eyelids being heavy/pulled down ? Seen frequently  in Myasthenia Gravis (For an EXAMPLE)  I'm not implying at all that you have MG.

 Try and get a complete Blood work-up ( CBC, Thyroid panels, Hormones, Calcium, Iron, CRP- for an Inflammation marker). Also  try and get a PET or SPECT brain scan.

 

 

Best of Luck  :)



#46 pheanix997

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Posted 04 February 2016 - 09:33 AM

Do you notice, see or feel your eyelids being heavy/pulled down ? Seen frequently  in Myasthenia Gravis (For an EXAMPLE)  I'm not implying at all that you have MG.

 Try and get a complete Blood work-up ( CBC, Thyroid panels, Hormones, Calcium, Iron, CRP- for an Inflammation marker). Also  try and get a PET or SPECT brain scan.

 

 

Best of Luck  :)

Wow I match all the symptoms of this... the dropping eyelids, the facial muscles feeling too weak to be expressive... it's like when I smile my brain and body feel weak/ tingly, so I keep a flat expression. I also have that tingly sensation feeling the OP is talking about when I speak for example. I feel considerable pain and discomfort when I do a simple thing like lifting up the bed mattress; I almost have to left my hands rest as they become almost numb. Also have the nasal voice and dystharia... 



#47 Sephrioth

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Posted 04 February 2016 - 10:41 AM

 

Thank you for your answer but I have already explained I do not have stress, anxiety or anything like that. I also really do not have a depression. Please read my original post and reactions carefully. This is physical, either caused by damage, hormonal/neurotransmitter dis-regulation or persistent infection. 

I still think depression is at least part of the picture. 

 

But your physical symptoms are probably real. I know because I have them too. I'm spatially disoriented, off-balance, have vision issues as well, etc. It's really, really impairing. And although I have depression and anxiety, it is frustrating when people chalk it up to JUST that. I think a lot of my issues stems from being born with ADD and with a family history of Alzheimer's, having lifelong stress and mild dysthymia causing damage, and then the many, many mild concussions I sustained over my hockey career. It's all cumulative. I know the feeling of being sedated/ drunk. In fact I started a thread about just this feeling a while back, you can look through it. I think being on an SSRI has contributed to it, but these problems go back much before I ever hopped on an anti-depressant. 

 

Anyway, I can't remember if you said you'd tried antidepressants? If I recall it seemed like that's the only thing you haven't tried. Wouldn't hurt to try... Edit: I looked and it seems you haven't tried any. I'm on wellbutrin and it helps a lot with this. I think you're past the realm of supplemental help and need to start trying pharmaceuticals, which will bring you closer to baseline where supplements would bring more improvements. 

 

If you find anything that helps please come back to update the thread because I'm in the same boat! Good luck! 

 

 

All my symptoms are real. Please read my previous post more carefully. This is a 24/7 condition. I know exactly what depression and anhedonia feel like. I get them sometimes because living like this is hell. But most of the time I do not suffer from them yet my brain-symptoms remain.

 

Yes anti-depressant DO HURT to try. Especially SSRI's with my other symptoms. They are counter indicated (cause further sedation, anhedonia and can have long lasting effect). Just ask some people on this or other forums.

 

Do you notice, see or feel your eyelids being heavy/pulled down ? Seen frequently  in Myasthenia Gravis (For an EXAMPLE)  I'm not implying at all that you have MG.

 Try and get a complete Blood work-up ( CBC, Thyroid panels, Hormones, Calcium, Iron, CRP- for an Inflammation marker). Also  try and get a PET or SPECT brain scan.

 

 

Best of Luck  :)

 

Sorry, but I never have had problems with my eyelids or anything else I didn't describe previously. I have had all sorts of blood tests including most of those.

 

I would really like a PET/F-MRI scan, but I can't get them here. They are only used for other diseases like Alzheimer and research purposes. I have found someone on the phoenix rising forum with almost exactly my symptoms. He had meningitis, from which he sustained brain damage and never recovered. The description he used for the strange dark dimmed vision, like seeing everything by candle light or walking from bright sunlight outside into a room, was the only time I have seen anyone describe it with my exact same words. He had a F-MRI/PET scan that showed very clearly a diffuse decreased activity.  



#48 FunkOdyssey

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Posted 04 February 2016 - 10:11 PM

 

I have read about Lyme a lot. I know it's difficult to treat. I have had many tests (Western blots / PCR etc). But never conclusively positive. Some positive bands, but not specific. And the PCR is frequently false-positive. It could be that the infection is too old, and I do not produce antibodies anymore. I am probably going to try Amoxicillin 3g daily,  to see if I get improvements.

 

 

 

As a former advocate of empiric antibiotic trials for suspected Lyme disease, I would urge you to tread very carefully and possibly reconsider  The risk of damage to your microbiome is real and the consequences can be lasting and severe.
 


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#49 pheanix997

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Posted 07 February 2016 - 04:39 AM

I found this book... maybe give it a read? Not sure if it'll address your issues but it's possible. I know you're obviously not blind but there may be one in there that talks about vision and cognition that might give you a new lead to investigate. 

 

Blind vision : the neuroscience of visual impairment by Zaira Cattaneo and Tomaso Vecchi

 

Table of Contents

  • Blindness and sensory compensation
  • The relationship between visual perception, imagery, and cognitive functions
  • Imagery and working memory processes in the blind
  • Spatial cognition in the blind
  • Low vision
  • The importance of blindness onset
  • Cortical plasticity and blindness.

 


Edited by pheanix997, 07 February 2016 - 04:40 AM.

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#50 Onyoursix

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Posted 11 February 2016 - 07:35 AM

I liked the extended fast suggestion.  I've done a 7-day water fast a few years ago and it was one of the best things I've ever done.  I plan on doing a 14 day water fast later this year.  While I didn't suffer from any symptoms like you are, it did heal chronic pain that I had due to an injury, I felt like I had an almost new body.


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#51 pheanix997

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Posted 08 March 2016 - 02:52 AM

This comment is only related to your vision problems, but I want to add that I heard that yellowing or dimming of vision can be early sign of cataracts... might want to rule it out OP.

#52 Caravaggio

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Posted 11 March 2016 - 08:09 AM

Hey Sephrioth,

 

because you mentioned you got better on Pregnenolone maybe you got some problem with your adrenal glands.

 

Check this: https://www.drlam.co...s-fatigue/1611/



#53 Jim2000

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Posted 15 March 2016 - 09:13 PM

Hi man. Do you eat oats regularly / semi-regularly?

 

I only skimmed the thread but for around 2-3 months I had very similar symptoms so I can relate to you. They started off mildly which got worse when taking certain supplements, then turned into full blown every day symptoms without taking anything.

 

I was waking up every day just as if someone had injected me with a sedative, and was forcing myself through every action of every day. Then I did a few diet tests and stopped eating oats that I was eating every day. Within about 5 days I noticed improvement and after 2 weeks I was way better. I still eat other grains fine, for some reason oats were causing these issues.

 

Secondly, I HIGHLY suggest you read the book 'You are the placebo' and put disbelief (if any) temporarily on hold until you get a decent way into the book. It will help you out a lot.

 

http://www.amazon.co...are the placebo


Edited by Jim2000, 15 March 2016 - 09:15 PM.


#54 Grey baron

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Posted 08 April 2016 - 04:21 AM

Don't listen to anyone who says this is depression or anxiety man, I have the same EXACT symptoms as you, it is NOTHING even close to depression or anxiety, it's actually offensive calling it that. It's nothing anyone can even imagine. I got mine from Propecia(Same as you), I read some of your posts over at propeciahelp as "NO". The extreme brain fog, seems like our vision is like 3 frames per second, vision dosent process with our brains correctly anymore, you feel as if your on Ketamine or DXM, I've been doing a lot of research and here it goes...

So what's happening to us is
1st. Propecia caused overexpression of our 5AR, silenced the regulatory gene from overexpression
2nd. Overexpression of 5ar leads to drastically increased neurosteroids and DHT
3rd. Neurosteroids such as allopregnanolone are inhibitors to NMDA and agonists to GABA
4th. Such down regulation of NMDA makes us feel as if we our on a Dissociative Anthesthetic(NMDA Antagonist)

Now I have found things that have helped,
PQQ is the main one I've been using the last week, it's been helping a little, to soon to get full benefits
I am going to try sacrosine, just ordered it will update on it

Oh, and I had a SPECT scan and fMRI, spinal tap, tons of blood work, EEG, ALL came back good, so there's no structural brain damage

Edited by Grey baron, 08 April 2016 - 04:53 AM.


#55 Grey baron

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Posted 08 April 2016 - 04:27 AM

I would trade places with almost any other disease, this truly is a living hell, never take propecia

#56 Grey baron

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Posted 16 May 2016 - 03:56 AM

Pregneolone is the only neurosteroid that is a NMDA agonist, the rest are antagonist.

So that is why you felt better with pregneolone, but of course using it will downregulate your nmda even more.

I haven't tried it, cause I don't want to risk getting even worse(don't know if that's possible)

If I could just fix either my visual processing, dimmed vision, or extreme brain fog, I would be happy, but unfortunately they all go together and you can't just fix one at a time, when vision problems get worse, so does brain fog

#57 Sephrioth

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Posted 16 May 2016 - 09:08 AM

when vision problems get worse, so does brain fog

 

This is exactly the same for me. Though the vision problems are not the most important, since I can still work with them.

 

Pregnenolone is no solution. I needed to increase the dosage and eventually it stopped working. I also think that higher Testosterone may lead to lower 5AR (binding and converting to DHT). That's why I seem to feel worse with high Testosterone. 


Edited by Sephrioth, 16 May 2016 - 09:09 AM.


#58 Sephrioth

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Posted 09 October 2016 - 12:49 PM

I had a few months where I felt a little better 65-70% ill (brainfog, drugged drunk) where 0% would be normal. Even then I felt ill, but at least I could work. My 3D work is everything to me, nothing else interest me much anymore because it's hard to enjoy anything feeling ill. It's like having the flue, but only in your head and without the fever. When I feel worse my vision also becomes ill/darker/dimmed with a strange contrast.

 

Unfortunately I am doing a lot worse again lately. I get tired of fighting this all the time. I always crash eventually, no matter how much I try to fight it and no matter how much discipline I have in my daily routines. In the end I just can't take it anymore. I lose my motivation when I feel ill all the time, although my 3D work is everything to me. As long as I take all the supplements, eat no sugars/carbohydrates and keep pushing through with my work I feel maybe 65%-70% ill (drugged drunk unmotivated) where 0% would be normal. This is bad enough but at least I can work.

 

I think I raise my neurotransmitters naturally by working, but then build up tolerance for my own dopamine/nor-ephedrine and NMDA receptors. This isn't sustainable, so I crash and lose lots of time. Then I feel 85-90% drugged/drunk/anhedonic again. I don't know how to describe it. I am not sleepy, but it feels like I haven't slept for days.

 

I have absolutely no anxiety or depression at all, also not subconscious! I know Anhedonia can be a symptom of depression, but for me it is the result of feeling too ill to work and being incapacitated.

 

Should I try Memantine for 10 days to revert Dopamine/NMDA tolerance? I am not looking forward to feeling even worse, but if there is a chance for improvement I would try it.

 

Pregnenolone is probably the only substance that ever gave substantial improvement. (I took a very low dose about 4-5 years ago intermittently for maybe a few month total). At first it worked well, then less and less, and eventually it stopped working (dose-independent).

 

A few days ago I tried Tianeptine sulfate, Adrafinil and Agomelatine (before bed). Only for a day and they did nothing (only got a headache). 

I have no interest in going to doctors anymore, because they know less then I do after all my years of research. Most of the time they don't even know what I am talking about. 

 

I really need help, this is ruining my life personally and work related :-(.


Edited by Sephrioth, 09 October 2016 - 12:55 PM.


#59 psychejunkie

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Posted 09 October 2016 - 12:59 PM

Any certain spiritual practices?



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#60 Sephrioth

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Posted 09 October 2016 - 01:04 PM

Any certain spiritual practices?

 

I am 99,999999% atheist, since nothing is 100% I guess.







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