Bacopa can never replace deprenyl...the impressive weight of antiaging studies on lifespan done on deprenyl and the fairly large number of human studies leaves Bacopa lacking clinical research. I currently recommend them both for best effects.
Michael severely criticised deprenyl's alledged life-extension properties in a another
thread here. how would you respond to those?
Deprenyl is often cited as a counterexample, but it really isn't. Yes, Knoll made an exciting single report (and repeated it in several journals), but he's the ONLY person to report an extension of max LS: lots of others show increases in av'g bu t not max, no extension at all, or even *increased* mortality. Flat ad hominem: Knoll had the patent on the stuff. See the desperate attempts to reconcile the data between different studies on pp. 3-8, esp. the lifespan discussions on pp 7-8, of (1). Much of this info (but without, alas, the unpublished stuff sumarized in (1)) is put in a tabular form in (2), which makes the fundamental lack of anything like a logical pattern in the results clear. IMO, this shows pretty clearly that even if you believe there's something to it as a life-extension drug, there is just no way that one can rationally USE it as such at this time as there is no basis upon which to reasonably extrapolate a dose which can be expected to consistently extend even AV'G LS in humans.
It doesn't appear to give any reliable benefits in animal systems; it seems to kill the folks it's designed to TREAT; I just do not see how the risk:benefit calculation can be fudged to make it come out in favor of use by young, healthy people.
So when I say that "Knoll made an exciting single report (and repeated it in several journals), but he's the ONLY person to report an extension of max LS: lots of others show increases in av'g bu t not max, no extension at all, or even *increased* mortality", I'm referring to this failure to extend the normal, healthy organism's lifespan, not to the alleviation of premature mortality in short-lived strains or animals raised under poor husbandry. It's easy to reduce mortality by antioxidants in short-lived strains or chorts -- it's been done with any number of compounds, from Harnam on -- and deprenyl has certainly been reported to do this several times, although (again) it has also increased mortality in others (eg (6)).