• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
              Advocacy & Research for Unlimited Lifespans

- - - - -

Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases

maria a blasco spanish national cancer centre (cnio) madrid spain tert gene therapy with aavs

  • Please log in to reply
No replies to this topic
⌛⇒ MITOMOUSE has been fully funded!

#1 alc

  • Validating
  • 208 posts
  • 101
  • Location:Columbus, OH
  • NO

Posted 27 January 2016 - 03:39 AM


"Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging. Here, we discuss the role of telomere shortening as a direct cause for aging and age-related diseases. In particular, we draw attention to the fact that telomere length influences longevity. Furthermore, we discuss intrinsic and environmental factors that can impact on human telomere erosion. Finally, we highlight recent advances in telomerase-based therapeutic strategies for the treatment of diseases associated with extremely short telomeres owing to mutations in telomerase, as well as age-related diseases, and ultimately aging itself."



  • Informative x 1

Also tagged with one or more of these keywords: maria a blasco, spanish national cancer centre (cnio) madrid, spain, tert gene therapy with aavs

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users