www.abc.net.au/news/2016-05-04/newcastle-scientist-discovering-healing-power-blood-protein/7383726
Newcastle scientist discovers healing power of blood protein GDF11 through stem cell research
#1
Posted 13 May 2016 - 02:08 AM
www.abc.net.au/news/2016-05-04/newcastle-scientist-discovering-healing-power-blood-protein/7383726
#2
Posted 14 May 2016 - 03:36 AM
You can invite to this discussion an individual from this forum ... he is a sens troll and small oracle at the same time ... lol ... he knows everything and anything before happens ... lol ... he created a discussion to convince that gdf11 gives up the throne of rejuvenation ... maybe right now he is hard editing his previous posts to cosmeticize them ... lol
and now seriously: there is a lot of evidence in this area of research, and we can pull a lot of meaningful data from parabiois for the groups like us that are interested (can I use the word "obsessed") in rejuvenation. Seems like there is a lot of good things coming out recently, indicating a lot of potential. For sure not the totally rejuvenation, we all dream about, but still will have a huge impact.
So the mini-Oracles and trolls should stop posting continuously same ss, and let the science move on. That way we can get to some results soon, instead of keep beating the bushes.
Thank you.
#3
Posted 14 May 2016 - 04:25 AM
You can invite to this discussion an individual from this forum ... he is a sens troll and small oracle at the same time ... lol ... he knows everything and anything before happens ... lol ... he created a discussion to convince that gdf11 gives up the throne of rejuvenation ... maybe right now he is hard editing his previous posts to cosmeticize them ... lol
and now seriously: there is a lot of evidence in this area of research, and we can pull a lot of meaningful data from parabiois for the groups like us that are interested (can I use the word "obsessed") in rejuvenation. Seems like there is a lot of good things coming out recently, indicating a lot of potential. For sure not the totally rejuvenation, we all dream about, but still will have a huge impact.
So the mini-Oracles and trolls should stop posting continuously same ss, and let the science move on. That way we can get to some results soon, instead of keep beating the bushes.
Thank you.
alc, the only troll is you.
What I posted was a paper penned by one of the most prominent scientists in the field. The titles was the one she had chosen for the paper.
If you want to call Irina Conboy a troll feel free to do it, her emails are public.
As for GDF11 I can post more than one paper questioning it's efficacy and most of them are not opinion pieces done by undergrads but papers done by whole teams with decades of accumulated work in the field. By the way, as the time goes on the more papers being published are ones questioning the original reports.
Here you go. Last 3 months.
This “Controversies in Cardiovascular Research” article evaluates the evidence for and against the
hypothesis that the circulating blood level of growth differentiation factor 11 (GDF11) decreases in old age and
that restoring normal GDF11 levels in old animals rejuvenates their skeletal muscle and reverses pathological
cardiac hypertrophy and cardiac dysfunction. Studies supporting the original GDF11 hypothesis in skeletal and
cardiac muscle have not been validated by several independent groups. These new studies have either found no
effects of restoring normal GDF11 levels on cardiac structure and function or have shown that increasing GDF11
or its closely related family member growth differentiation factor 8 actually impairs skeletal muscle repair in old
animals. One possible explanation for what seems to be mutually exclusive findings is that the original reagent
used to measure GDF11 levels also detected many other molecules so that age-dependent changes in GDF11 are
still not well known. The more important issue is whether increasing blood [GDF11] repairs old skeletal muscle
and reverses age-related cardiac pathologies. There are substantial new and existing data showing that GDF8/11
can exacerbate rather than rejuvenate skeletal muscle injury in old animals. There is also new evidence disputing
the idea that there is pathological hypertrophy in old C57bl6 mice and that GDF11 therapy can reverse cardiac
pathologies. Finally, high [GDF11] causes reductions in body and heart weight in both young and old animals,
suggestive of a cachexia effect. Our conclusion is that elevating blood levels of GDF11 in the aged might cause
more harm than good.
(
Circ Res
. 2016;118:1143-1150. DOI: 10.1161/CIRCRESAHA.116.307962.)
Another one.
Summary
Recent high-profile studies report GDF11 to be a key circulating ‘anti-aging’ factor. However, a screen of extracellular proteins attempting to identify factors with ‘anti-aging’ phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.
http://onlinelibrary... inconvenience.
The closest I've seen to a new paper saying GDF11 is in any way good or useful is the one done by the original Walker group and even they are not so blindly enthusiastic about it to say this is as clean cut a topic as you would like to think it is
Effect of GDF11 Supplementation on Cardiac
Hypertrophy
Our studies published in 2013
24
and 2015
111
reported an anti-
hypertrophic effect of rGDF11 administration by comparing
heart weight/tibia length ratio in treated and control aging
mice, whereas the study by Smith et al
110
reported no effects
on the heart. As discussed above, this disagreement may re-
late to dose-dependent effects of rGDF11 on cardiac mass,
but it is also important to emphasize that Smith et al
110
did
not observe changes in body weight in rGDF11 injected mice,
whereas we reported a significant decrease in body weight inaging mice with exogenous rGDF11.
111
Observations from
our laboratories indicate that exogenous rGDF11 decreases
body weight in old mice in a dose-dependent manner (unpub-
lished data and studies by Sinha et al,
24
and Poggioli et al
111
).
Although rGDF11 directly activates SMAD signaling in car
-
diomyocytes,
111
it is also possible that the reduction in cardiac
size with exogenous rGDF11 in vivo is because of an indi-
rect effect of rGDF11. A systemic signal, possibly initiated
by a reduction in body size or a change in a specific tissue, is
plausible. For example, there is a clear evidence for cross talk
between adipose tissue and cardiac
166,167
and skeletal
139,168,169
tissues. Thus, any interpretation of a direct effect of rGDF11
on the myocardium must be considered in the context of its
systemic effects.
In conclusion, GDF11 has emerged as an intriguing can-
didate in the regulation of vertebrate aging and considerable
progress has been made in the analysis of its role in the pro-
gression of age-associated disease. Future investigation of
GDF11 and myostatin biology and biochemistry will clarify
the similarities and differences in the functions of these pro-
teins and advance our understanding of organismal aging and
disease.
Strange how the "trolls" in the medical community got activated one by one, huh.
I guess they all want to troll you personally.
You're hilarious. And a bit pitiable.
I had decided not to involve myself with this topic but I guess it's better that I do than to let disinfo blossom on a forum which should have rational stances on medical science.
#4
Posted 16 May 2016 - 01:03 AM
(OT but funny] - thanks for turning yourself in ... lol ...you fell into the trap immediately, because the troll cannot resist the temptation for posting on every subject ... lol ... logic is what fails you first, then the troll attitude that result in weak understanding in many subjects ... keep trying though (meanwhile, science moves on).
#5
Posted 02 June 2016 - 07:33 AM
Wagers original study may be correct and the second group may have misidentified the protein (gdf8 and another) as wagers has since stated. But the second group are still sticking by their testing results. But time will tell who's correct.
Edited by pleb, 02 June 2016 - 07:34 AM.
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