3 replies to this topic

[SearchHorizon]

I have not posted much, but have been reading lots of posts in longecity forums.

 

I'd be grateful any feedback on l-serine.

 

 

[Kinesis]

I've supplemented with l serine on the theory that it might help boost endogenous phosphatidylserine production. PS itself unfortunately is not a specific compound since it contains two unspecified fatty acids. Most of the early research on PS was extracted from bovine brain and could have been different than the commercial soy based product. Brain sourced PS would for example likely contain DHA not found in plant sourced PS.

You can now buy DHA spiked PS but it's expensive and still doesn't contain much DHA. A better approach would be to take PS without the fatty acids (analogously to GPC which is phosphatidylcholine without the fatty acids) and take DHA with it, but as far as I know no one yet markets such a thing.

So I take GPC, DHA and serine.

[SearchHorizon]

I had an opportunity to observe my mom's memory on l-serine - the effect has been negative. Bad forgetfulness.

 

So, I have updated my theory - L-serine is known to convert to d-serine, which increases GABA workings. But GABA is inhibitory, which leads to forgetfulness.

 

I have seen PS having a positive effect on my mom's memory, so to me it appears that PS's positive effect comes from the phosphatidyl component, and not the serine portion.

 

One way to test the preceding theory is to try something similar, such as phosphatidylcholine (PC). I know that there are research data that supports its positive effects on memory. Choline is a bit excitatory, so PC should be more helpful for memory than PS.  

 

 

Edited by SearchHorizon, 06 June 2016 - 02:57 AM.

[Kinesis]

According to Examine.com

"D-Serine is an amino acid that plays a role in cognitive enhancement and schizophrenia treatment."

https://examine.com/...ments/d-serine/

Edited by Kinesis, 08 June 2016 - 11:21 PM.