Here's an article:
http://www.reuters.c...50§ion=news
Some kid has no myostatin gene, and suffers from big muscles
I'd imagine that the athletic industry would exploit this once they figure out how
Posted 23 June 2004 - 11:45 PM
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Posted 24 June 2004 - 12:58 PM
but where is the big penis gene?
Posted 24 June 2004 - 02:14 PM
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Edited by prometheus, 27 June 2004 - 12:37 PM.
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Edited by caston, 21 October 2007 - 04:30 PM.
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Posted 26 October 2007 - 06:57 AM
Myostatin inhibitors present a particularly interesting case for WADA. In 2004, scientists published a paper describing an abnormally muscular German toddler who carried mutations in both copies of his myostatin gene. The boy's mother, who had been a professional athlete, was found to have one defective copy of the gene, raising questions about how to deal with athletes who have naturally occurring genetic mutations that give them benefits similar to those offered by performance-enhancing drugs. "We have ethicists thinking about those issues and guiding us in the future," says Rabin. "We need to maintain fair play for all competitors." The issue is likely to grow as advances in genomics allow scientists to uncover additional variants linked to muscle, or other factors related to athletic ability.
Posted 27 October 2007 - 03:20 AM
So if they find that some people are smarter because of a naturally occurring mutation, will they be banned from universities? If they ban all the people with good coordination and strength, maybe I'd be competitive then! Wow, never thought of it that way. Maybe we could ban overly good looking guys from hanging out in singles bars so us normal looking guys would have a better chance. We clearly need a lot more ethicists working on these problems. After all, "we need to maintain fair play for all competitors." Natural selection is so politically incorrect.Myostatin inhibitors present a particularly interesting case for WADA. In 2004, scientists published a paper describing an abnormally muscular German toddler who carried mutations in both copies of his myostatin gene. The boy's mother, who had been a professional athlete, was found to have one defective copy of the gene, raising questions about how to deal with athletes who have naturally occurring genetic mutations that give them benefits similar to those offered by performance-enhancing drugs. "We have ethicists thinking about those issues and guiding us in the future," says Rabin. "We need to maintain fair play for all competitors." The issue is likely to grow as advances in genomics allow scientists to uncover additional variants linked to muscle, or other factors related to athletic ability.
Posted 27 October 2007 - 11:53 PM
Posted 28 October 2007 - 01:19 AM
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Posted 30 October 2007 - 01:08 AM
What would happen to the heart, diaphragm, or other muscles with extended use of these blockers?
How about any side effects? Nobody seem to know of any from all the places I've searched. Don't you think that the down-regulation in the production of myostatin in the muscle stem cells could come back to bite us?
Posted 31 October 2007 - 09:37 PM
What would happen to the heart, diaphragm, or other muscles with extended use of these blockers?
How about any side effects? Nobody seem to know of any from all the places I've searched. Don't you think that the down-regulation in the production of myostatin in the muscle stem cells could come back to bite us?
These are of course very important questions, which deserve strong consideration.
There are too my knowledge 2 humans lacking functional mystatin (granted I haven't done any research on the matter lately). Hardly a significant sample, and they are both children. We have no evidence to suggest what impact myostatin blocking may have on long term health in human beings.
However, in mice with the myostatin gene knocked out there does not appear to be any obvious detrimental effect, to the cardiac muscle.1 However there is apparently a size difference between the no myostatin group and a high myostatin group, but no difference in function was noted.2
It's also very important to keep in mind that even after loads of animal testing, and a seemingly excellent understanding of pathways involved in many systems people still do die in phase one clinical trials.3 This is something to keep in mind when using substances that have only been tested on animals.
1. Neuromuscul Disord. 2007 Apr;17(4):290-6
2. J Endocrinol. 2007 Jul;194(1):63-76
3. Annals of Oncology 1:175-181, 1990
Posted 04 January 2008 - 10:02 PM
The ingredients and some hype for it are below. I was alarmed that they use artificial color, and it made me wonder about the product and its claims."It's a myostatin-binding extract obtained from cystoseira canariensis, the brown sea algae which has been shown in laboratory experiments to have myostatin-binding capabilities"
SUPPLEMENT FACTS Serving size 4 caplets
Amount Per Serving % Daily Value*
Sodium 40 mg 2%
Potassium 40 mg 1%
Cystoseira canariensis 1200 mg †
* Percent Daily Values are based on a 2,000 calorie diet
† Daily Value not established
Active ingredients: Cystoseira canariensis Fraction-C extract (> 90% sulfo-polysaccharide), sodium lactate, potassium lactate, rhodiola rosea (standardized to 5% rosavin), rhaponticum carthamoides, piperin (piper nigrum).
Other ingredients: Dicalcium phosphate, cellulose, stearic acid, magnesium stearate, titanium dioxide, blue #1, yellow #5.
Your Genetics Are Powerless to Stop Us.
For as long as you’ve been lifting weights you’ve probably been told that your genetics will ultimately determine how strong, how big, and how lean you can get. You were also told that muscle cells don’t divide and the one’s you have will grow only so much. You learned that, short of resorting to risky alternatives, you’d eventually reach a point where your improvement would slow to a crawl or stop altogether.
Worst of all, this logic was more or less correct.
Everything is about to change
Today, we are standing at the forefront of the greatest discovery for athletes in the last fifty years. Recently researchers have discovered the primary gene for the control of muscle. This gene makes a peptide that prevents muscle growth and increases fat storage. They call it myostatin.
If you want to get lean and gain muscle or strength, myostatin is your worst enemy. It is the one peptide in your body whose only mission is to stop you from getting in better shape! Everyone makes myostatin, and it is the primary reason why it is almost impossible to make dramatic increases in muscle size and performance naturally. That’s because every time you do something that stimulates improvement, your body stops it with a burst of myostatin.
Suppress myostatin and muscles begin to grow naturally
The eternal question: Do muscle cells divide or just get bigger?
Just before this went on the web we got hold of a study that answered the question that has been nagging muscle researchers for 30 years: Under the right influences can you force muscle cells to divide? This new research shows that by controlling myostatin you can actually do something even better!! When you suppress myostatin prior to training three things happen:
Satellite cells begin dividing rapidly - when myostatin is suppressed. Satellite cells used to be thought of as just embryonic cells that played little role in the adult. Now they are know to be the key to muscle growth!
*
Satellite cells convert to Myoblast cells. Myoblasts become very active - when myostatin is suppressed
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Myoblasts bind to muscle cells and add new nuclei to the muscle cell - this is what allows a mature muscle cell to grow bigger (the size of a muscle cell is directly related to the number of nuclei it has).
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Myoblasts begin producing microtubules that form the membranes of brand new muscle cells! Myoblasts add nuclei to these microtubules and a new muscle cell is born.
Posted 04 January 2008 - 10:18 PM
Posted 04 January 2008 - 10:20 PM
Posted 04 January 2008 - 10:36 PM
Thanks. I would never buy it without investigating it...that's why I posted here.Here is a pretty definitive study that shows this stuff doesnt work. http://www.ncbi.nlm....;indexed=google
No significant difference between the placebo group and the Cystoseira canariensis (myostim group) after 12 weeks.
As a rule I am very very wary of anything marketed to the bodybuilding world these days. The marketing gurus have made an art form out of making their products sound like high tech pharmaceuticals with amazing results and very few side effects. Often these claims are completely untrue. When they are at least partially true, the substance is usually a new tweaked prohormone or steroid derivative that simply hasn't been classified for what it really is, a new steroid and an attempt to sell something to the public for a time until the FDA bans it.
Research research research before wasting money on products like this.
do you think this could have any validity?Unless enteric coated, up to 99% of the myostatin binder may be destroyed during digestion.
Thanks.Here's a discussion from last year.
http://www.imminst.o...&...st&p=201925
Posted 04 January 2008 - 10:40 PM
Posted 04 January 2008 - 10:55 PM
There are a few of these "natural" myostatin blockers on the market. If they really worked they would already be banned because they would be as powerful or more powerful than steroids (according to a couple popular articles I have read). Animals who lack the gene that produces myostatin look like freaks of nature, even cartoonish, because they have so much muscle. Some pharma labs are working on true functional myostatin blockers, in the hopes of helping older people who suffer from muscle loss. Of course, athletes and bodybuilders will want to get their hands on the stuff, and many sports leagues will probably ban it (sad).
I suppose it could be dangerous in the fact that people could develop much more muscle than their hearts, lungs, or other organs could handle. Myostatin is probably part of an evolved system to prevent the muscles from growing in order to conserve energy. If muscles grew with no limit, then the body would need greatly increased amounts of food and that would be bad for survival (back on the african plains).
Still, it is not as if myostatin blocks all muscle growth (like the "hype" statement above claims), it just makes it harder to gain muscle mass.
Posted 04 January 2008 - 11:59 PM
Edited by shepard, 05 January 2008 - 12:08 AM.
Posted 07 August 2008 - 02:45 PM
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