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Best Anti-Depressant combination with the least side effects?

anti depressantwellbutrinlexapro prozac depression anhedonia social anhedonia

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#1 Iamnobodi

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Posted 11 July 2016 - 11:38 AM


I am currently going through a rut in my life which includes anhedonia including social anhedonia, blank mind and underlying depression. Also feels like my memory has gone to shit. 

 

I was on Brintelix, and although I felt better after a few days I stopped due to sexual side effects. My penis and balls felt numb. 

 

After some research I found Wellbutrin, which apparently has the least amount of sexual side effects & may actually improve sexual function.

 

There is also lexapro which was reported by a LongeCity user to be the "cleanest SSRI" in terms of side effects. 

 

I saw another member recommend a combination of Prozac and Wellbutrin to combat sexual side effects.

 

A little background about me I have history of recreational marijuana use and probably abused MDMA. But have been off drugs for close to a year now. I think I'll probably cut out alcohol as we'll. 



#2 jack black

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Posted 11 July 2016 - 06:29 PM

wellbutrin sounds good on paper but can give you hell (including suicide ) in the first couple of weeks. I know it firsthand and from a member of family too. IMHO, the best way is to boost BDNF (naturally or by drugs). Search this forum for BDNF. Stopping ethanol and stress is a good idea (they lower BDNF).


Edited by jack black, 11 July 2016 - 06:40 PM.


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#3 Mind_Paralysis

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Posted 13 July 2016 - 11:26 AM

Lamnobodi: Do you, or have you, or anyone else close to you, suspected any other diseases or disorders, that might ail you?

Like, is there any signs whatsoever of ADHD, SCT, Autism, Schizotypal disorders, et c.

Also, important, how is it that you got hooked on Weed? It's fairly unusual to smoke to such an extent that one gets permanent problems. Not trying to be offensive or anything, but the only people I know, or have seen, to do so, are people that suffer from one neuropsychiatric disorder or another, and who are subconsciously looking for treatment - they find some of that in Cannabis and then start using it excessively, eventually ending up with problems because of excess.

 

As for what combo I think works - well, if you are ADHD-PI like me, then one of the best combos is this:

 

Bupropion (wellbutrin, voxra) + Agomelatine (valdoxan)

 

Combination of agomelatine and bupropion for treatment-resistant depression: results from a chart review study including a matched control group

http://www.ncbi.nlm....les/PMC4356843/

 

I've tried it myself and can vouch for the efficacy - highly effective, didn't take long at all for this combo to break my depression and anhedonia.

 

However, word of warning, Agomelatine did not affect Bupropion -induced aggression, I still got this to an extent, only sligthtly less so during the titration-phase. It also doesn't affect the selective memory-impairment that Bupropion causes, I still got dumb when it came to word-recall.

 

If you're looking for BDNF-support, then go take a look in the NSI-189 thread, there is a fellow there who gets a hold of that neurogenic compound now and then, and he may be of service in that regard.



#4 jack black

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Posted 13 July 2016 - 02:50 PM

It's fairly unusual to smoke to such an extent that one gets permanent problems.

 

 

I thought one can get lasting effects from abusing ecstasy?

 

 

As for what combo I think works - well, if you are ADHD-PI like me, then one of the best combos is this:

 

Bupropion (wellbutrin, voxra) + Agomelatine (valdoxan)

 

Combination of agomelatine and bupropion for treatment-resistant depression: results from a chart review study including a matched control group

http://www.ncbi.nlm....les/PMC4356843/

 

Agomelatine (valdoxan): Interesting drug. Do you take it at AM or PM? Can you just take Melatonin instead of this? It's not available in USA.
 



#5 Mind_Paralysis

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Posted 13 July 2016 - 08:24 PM

BURNOUT! Must give EVERYTHING to answer this! Aaaaaaarrrghh!!!
 

 

It's fairly unusual to smoke to such an extent that one gets permanent problems.

 

 

I thought one can get lasting effects from abusing ecstasy?

 

 

As for what combo I think works - well, if you are ADHD-PI like me, then one of the best combos is this:

 

Bupropion (wellbutrin, voxra) + Agomelatine (valdoxan)

 

Combination of agomelatine and bupropion for treatment-resistant depression: results from a chart review study including a matched control group

http://www.ncbi.nlm....les/PMC4356843/

 

Agomelatine (valdoxan): Interesting drug. Do you take it at AM or PM? Can you just take Melatonin instead of this? It's not available in USA.
 

 

 

I meant smoking in relation to Cannabis, of course one can get cognitive decline from the abuse of heavier drugs - chief one being Methampetamine - crystal meth ain't no joke, dude!

 

I take Agomelatine PM - if you take it AM it's going to cause somnolence, it may also interfere with your circadian rhythm then as well. One of the prescribed uses here in Europe is for the treatment of circadian rhytm disorder - and other diseases where such symptoms are indicated. For the actual antidepressant effect, you can't just take Melatonin - although it's been reported to have some effect, it's too low to be the central AD -effect.

 

The AD-effect from Agomelatine is believed to mainly come from it's 5ht2c -antagonism -effect - it also increases norepinephrinergic an dopaminergic signalling in the Pre-frontal Cortex, and hence why it's shown some small benefit for ADHD-treatment as well. This is also the main reason why it has a positive rebound-effect! = ) The MT1-2 agonism is only active the first few hours, after that, the 5ht2c-antagonism kicks in, and GIVES you energy instead!

 

Good stuff, on that effect alone. First time I took it, was actually like the first time I took Methylphenidate or Dexamphetamine! But WITHOUT the psychomotor effects - the cleanest, most relieving stimulant effect I have ever experienced. However, this was the stimulant-naive me, and this effect has never been repeated other than that first round - I call it the "novelty-effect", since it seems to happen to various degrees every time I try a new form of stimulation.



#6 Agent0023

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Posted 18 July 2016 - 03:11 AM

"California Rocket Fuel"

 

I found mirtazepine 45mg. hs and venlafaxine 300mg. qam the best for me. 

 

http://mentalhealthd...ne-combination/

 

Ramping up the mirtaz dose is probably good if you'd be alarmed awakening to psilocybin like visual illusions for midnite toileting (only for the first week or so.)   They pass.   I was not at all alarmed; found it amusing.



#7 Agent0023

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Posted 18 July 2016 - 03:15 AM

sorry repeat post... my bad


Edited by Senolytic Agent 0023, 18 July 2016 - 03:17 AM.


#8 dopaminerush

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Posted 03 May 2018 - 11:29 PM

i think they should do a agomelatine tablet  which contains a high dose thick melatonin layer on it and disolves around 3-4 hours. After that agomelatine will kick in for 3-4 hours and booom you wake up resfreshed.

 

agomelatin is givingn you very short sleep.



#9 dojob

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Posted 04 May 2018 - 10:28 AM

I'm currently taking Tianeptine sulfate as a nootropic. No side effects. I must mention the effect itself is not very strong too.

If i were you i would try that one first.



#10 Hyperflux

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Posted 05 May 2018 - 07:10 AM

I'm currently taking Tianeptine sulfate as a nootropic. No side effects. I must mention the effect itself is not very strong too.

If i were you i would try that one first.

 

Dose?



#11 dojob

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Posted 05 May 2018 - 09:36 AM

Dose?

40 mg in the morning. on busy days another 20 at around 4 pm.

if you want to try it i suggest starting at 20mg.



#12 normalizing

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Posted 05 May 2018 - 05:25 PM

I'm currently taking Tianeptine sulfate as a nootropic. No side effects. I must mention the effect itself is not very strong too.

If i were you i would try that one first.

 

the sodium version works but sulfate is questionable for many. personally, no effect for me, while sodium version works instant except its short lived. i guess its good for anxiety but sulfate is not good for anything really



#13 stan08

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Posted 05 May 2018 - 07:49 PM

the sodium version works but sulfate is questionable for many. personally, no effect for me, while sodium version works instant except its short lived. i guess its good for anxiety but sulfate is not good for anything really


Have you tried the free acid version? Curious as to how it compares to sulfate and sodium.

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#14 normalizing

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Posted 06 May 2018 - 04:15 PM

i havent but from what i read its like sulfate version, it doesnt stick and works similar way etc. i would like to try it but its more expensive than both other versions







Also tagged with one or more of these keywords: anti depressantwellbutrinlexapro, prozac, depression, anhedonia, social anhedonia

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