I was a little disappointed with the little interest I found searching for posts on beta 1,3/1,6 glucan linkage in this community. I wish someone could shed some light.
A. Dosage? Is there any clinical trial that suggests a specific amount of beta glucan for immune enhancement / protection? I have read loose statements without particular reference to studies that 3,000 - 15,000 mg as daily intake is needed for it to yield positive results.
B. Linkage Percentage; PSK (NOT PSP!) or Baker's yeast does it even matter? Baker's yeast apparently has the highest concentration of this dietary fiber extract. According to what I have gathered, one issue that may arise is purity, something that yeast allergic patients must be informed of, the same with individuals who (may unknowingly have) inflammatory bowel diseases, Crohn's, intestinal permeability. Mannan is one of the components responsible for this reaction and must be isolated from the b. g. Regarding purity, to me it feels like AMD Athlon vs Intel Pentium wherein one may seem to have higher amounts in figures (numbers) but is actually slower or just as fast as the other [- that still lingers as heated debate]. According to http://www.beta-glucan-13d.com/, "the higher the Active Linkage, the more effective the product will be." It has also made clear that no clinical trials were made using an active linkage below 85%. The Japanese use Coriolus / Trametes versicolor as their source for the extract (PSK, polysaccharide krestin), and I haven't found any on the market that carries a mushroom extract above 85%. So it brings me to question, provided that they have the same mass and percentage of purity, would taking a baker's yeast extract yield the same results as with taking a Coriolus versicolor derived glucan? Is there an existing comparative analysis on this?
C. Brand suggestions, please? I have not found much, unfortunately:
- Baker's yeast: Life Source claims to have 95% purity but this 2004 analysis says otherwise. Webpage typo?
- Mushroom: Mushroom Science / JHSNP only 36%, which has a very misleading description. First, the inclusion of a beta 1-4 (see URL) when it is, in fact, not found in the bottle label. And then why would they not print "PSK" instead of "protein-bound polysaccharide", which may be mistaken for PSP (Polysaccharide peptide)? I am not sure either, but this is crucial since studies on PSP declared it as having failed to support immune enhancement
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