11 replies to this topic

[MrHappy]

http://www.nejm.org/...6/NEJMoa1515319
...
RESULTS
After 27 patients were enrolled, the study was halted early, because telomere attrition was reduced in all 12 patients who could be evaluated for the primary end point; in the intention-to-treat analysis, 12 of 27 patients (44%; 95% confidence interval [CI], 26 to 64) met the primary efficacy end point. Unexpectedly, almost all the patients (11 of 12, 92%) had a gain in telomere length at 24 months as compared with baseline (mean increase, 386 bp [95% CI, 178 to 593]); in exploratory analyses, similar increases were observed at 6 months (16 of 21 patients; mean increase, 175 bp [95% CI, 79 to 271]) and 12 months (16 of 18 patients; mean increase, 360 bp [95% CI, 209 to 512]). Hematologic responses occurred in 19 of 24 patients (79%) who could be evaluated at 3 months and in 10 of 12 patients (83%) who could be evaluated at 24 months. Known adverse effects of danazol — elevated liver-enzyme levels and muscle cramps — of grade 2 or less occurred in 41% and 33% of the patients, respectively.

[AlephNull]

I came here with the exact intention of posting this same link.

Very interesting stuff!

So, who's going to be the first to try it?

[Rocket]

I came here with the exact intention of posting this same link.

Very interesting stuff!

So, who's going to be the first to try it?

 

It's not just Danazol!!!  Anabolic steroids (including testosterone) increase telomere length.  Searching is your friend............. 

 

Considering how weak Danazol is, I wonder what the more potent adrogens like Nandrolone and Trenbolone do to telomere length.
 

[motorcitykid]

I guess the juice heads had it right, keep it simple lol

 

I wonder if ostarine would have a similar effect on telomeres, working on the androgen receptors to increase telomere length without working on the liver.

Edited by motorcitykid, 28 July 2016 - 05:16 PM.

[PeaceAndProsperity]

If it is true that androgens in general increase telomere length, how come people like Rich Piana look prematurely aged? Yes, he and his likes abuse growth hormone, which reduces telomere length, but still.

Trenbolone is supposedly also inflammatory, causing premature graying of hair in some (or so he suggests).

[motorcitykid]

If it is true that androgens in general increase telomere length, how come people like Rich Piana look prematurely aged? Yes, he and his likes abuse growth hormone, which reduces telomere length, but still.

Trenbolone is supposedly also inflammatory, causing premature graying of hair in some (or so he suggests).

You're referencing Rich Piana who probably abused Tren in combination with other steroids over many years. A person could wreck their liver with too much green tea extract so yeah taking Tren for years in combo with other steroids will accelerate the aging process.

Danazol is a mild anabolic steroid(mild on the liver as well)  compared to Trenbolone. We don't know if Trenbolone would have the same effect or a reverse effect on telomeres.

 

IMO, Ostarine(a SARM) might be a good candidate for increasing telomere length. Ostarine is androgenic and is not methylated(unlike anabolic steroids) so it doesn't turn your liver to mush.

[motorcitykid]

On the other side of the coin, Danazol increases telomerase which increases telomere length. Increase in telomerase is associated with an increase in cancer which could explain why people who abuse anabolic steroids are more likely to develop cancer.

Edited by motorcitykid, 29 July 2016 - 06:21 AM.

[playground]

Where is the evidence that Testosterone and DHT lengthen telomeres ?

 

Thanks to anyone that replies to this question :-)

 

What we need... Is a comparison chart showing how much telomere lengthening

is achieved with different steroids... and this would include Testosterone and DHT

(and perhaps estrogen and progesterone too)

[PeaceAndProsperity]

http://www.ncbi.nlm....pubmed/26789780

Wow.. reading this, I wonder why it is that "steroid" abusers tend to look aged and tend to have skin that looks senescent.

Is abusing growth hormone really enough to speed up the shortening of telomere length, even in the face of compounds that increase telomere length?

[Sky_hi]

Tren has gotten a bad reputation. First off its underground lab form it's 200mg/ml in strength injectable oil which would only involve one shot a week and a sustained release. Tablets must be formulated to bypass the liver on the first pass and that very fact makes things harder on the liver. But if it's androgenic that is the property that's desired then tren would seem to be the ideal substance. You see trenbolone is 5 times more androgenic then testosterone so it seems to me that a lower dose would be required. This combined with the fact there is no first pass with the liver issues to deal with might just make it the ideal substance in a lower dose.

[Rocket]

Steroid users do not tend to look older. There are somewhat famous people who used steroids who also lived poor lifestyles that look like hell. The older steroid users I know and knew who lived healthy lifestyles all look(ed) great for their age... Better than their peers. Used in moderation and cycled correctly with proper support, steroids could do more for older people and muscle loss and weakness than any other treatment available today. You just need to watch RBC counts and donate blood occasionally if you're concerned , and watch your lipid values and eat a healthy diet with proper supplements for lipids, such as niacin and garlic. And they key word is CYCLE, don't live on them all year long.

Here is a link to a nandrolone government trial...

https://clinicaltria...how/NCT02055456

Edit: I'm only referring to injectibles. Oral steroids are hell on the liver. Orals can be nasty nasty stuff.

Edited by Rocket, 30 July 2016 - 02:58 AM.

[sthira]

Researchers at the National Institutes of Health (NIH) are studying if the medication danazol can be used to treat people with short telomere disease who also have bone marrow failure, liver, or lung disease.

In recent studies, danazol, at high doses, showed a positive influence on telomere length. Additional research is needed to learn more about the role of different doses of danazol on telomere disease as well as its effects on secondary diseases.

Eligible participants:

Are 3 and older (minors must have parent/guardian consent to participate);

Are diagnosed with a short telomere disease;

Also have abnormalities affecting the bone marrow such as aplastic anemia or low blood counts OR lung disease OR liver disease

Study procedures:

Before starting danazol, you will have tests and evaluations including measurements of your telomere length.

Depending on your secondary disease you may also have a bone marrow biopsy, lung function tests, or evaluation of your liver.

You will then begin taking danazol either 100 mg twice a day, or 200 mg twice a day for up to a year.

While taking danazol you will have outpatient visits to the NIH Clinical Center after 6 months, a year, and 6 months after stopping danazol.

Your participation in this study will last about 2 years.

Study-related tests, procedures, and medications are at no-cost. Travel within the United States may be reimbursed by the study team.