Name: SENS5 - LysoSENS A synthetic biology approach to treat age-related macular degeneration
Category: BioScience
Date Added: 21 December 2011 - 08:39 PM
Submitter: jdgauchat
Short Description: The Fifth SENS conference - Lorenzo Albanello
© SENS Foundation 2011 - http://www.sens.org
The Fifth SENS conference - Lorenzo Albanello
Speaker & Author: Lorenzo Albanello
SENS Foundation Research Center
A2E is a toxic compound that is formed in the lysosomes of retinal pigment epithelial (RPE) cells, as a normal by-product of the vitamin A metabolism that is essential for photoreceptor activity. It is a major component of RPE lipofuscin, which is thought to mediate light-induced oxidative damage associated with aging due to its photosensitive nature; its presence leads to the formation of epoxides that are even more toxic to the host cell. I'm studying the potential of enzyme replacement strategies to help the RPE get rid of A2E, breaking it down into less toxic catabolic products. This can be achieved in two ways: either by systemically delivering particular enzymes that are engineered to target a receptor that will cause those enzymes to be endocytosed and directed into the cells' lysosomes; or by using a gene therapy approach to enable the RPE to degrade A2E autonomously. Both approaches are being investigated by the LysoSENS project, which is now using novel methods for gene assembly to accelerate our research, giving us the ability to study our therapeutic strategies in medium-throughput assays in cultured RPE cells.
View Video
[Video] SENS5 - LysoSENS A synthetic biology approach to treat age-related macular degeneration
Started by
jdgauchat
, Aug 16 2016 03:08 PM
video
No replies to this topic
Also tagged with one or more of these keywords: video
Round Table Discussion →
Technology →
AI & Singularity →
NUWA - one really big and wicked AIStarted by Dream Big , 27 Nov 2021 video, vision, complex |
|
|
||
Round Table Discussion →
Risks & Survival →
COVID →
COVID-19 Solutions Videos - CritiqueStarted by Mind , 30 Mar 2020 covid-19, mind, video |
|
|
||
Round Table Discussion →
Risks & Survival →
Cryonics →
[Video] American Chemical Society on CryonicsStarted by caliban , 20 Dec 2019 video |
|
|
||
Community →
News & Resources →
Multi-Media →
Turn your cell phone into a Cell phoneStarted by Engadin , 14 Mar 2019 cell phone, wallpaper, video |
|
|
||
Science & Health →
Brain Health →
Brain Science News 012: 19 Strategies of Willpower, Stress Trick, Facebook Impairs Decision-Making, and moreStarted by spinola , 23 Feb 2019 video, psychology |
|
|
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users