15 replies to this topic

[Flex]

I got a gadolinium poisoning back in spring 2016 and wanted to ask if somebody knows any chelates (i.e. treatment options) for this. I found some things by my self and will add them with the time.

I create this thread also to collect informations for any metal intoxication in order to provide a platform for others.

 

Edit: Yeah I´ve visited a doc and everyone should visit a doc in this case but the docs where I went were clueless and I suggested one actualy a treatment option (facepalm) and I´m tired to hear the EDTA panacea. Yes it is a credible antidote but with problematic side effects and of course not very helpful for all metals like Gadolinium, unlike Ca/Zn-Dtpa.

In addition, I´ve stumbled over a lot of misinformations about additional OTC remedies e.g. alpha lipoic acid (ALA) which is actually harmful because it binds metals but releases them elsewhere in the body.

 

Edited by Flex, 01 November 2016 - 11:40 PM.

[gamesguru]

Speed of implementation.  you seriously found about this months ago, only to take action today?  Supremely irrational behavior from a divinely rational mind

 

deferoxamine is too weak, so maybe google kidney supplements?  Is that the right approach?  With so little research on common chelators against gadolinum (most are studied on mercury or lead only.. but unbeknownst to us, one could be an incredible chelator of gadolinium), it is hard to make a call.  But yeah, I wouldn't be surprised to uncover a kidney condition as a major contributor

[fluidity]

I'm on the same boat. My mercury amalgam has destroyed my life. I'm not even the same person I once was before it began leaking. It got worse especially after the I removed it which increased the deposition of mercury into my body. I've been dealing with mercury toxicity for 2 years now and I literally feel as though life is passing by without me experiencing it. This infernal poison is sapping years away from my life and this is during a relatively young age for me(early twenties). I'm not going to get these years back which deeply angers me.

 

As a side recommendation be EXTREMELY careful with iodine. It mobilzes metals but doesn't chelate them out. It raised my symptoms of mercury by 10 fold and I no longer even have the motivation to do anything anymore. My dopamine systems are beyond shot. 

 

I really wish someone can help me here as this is a cry for help. To get my life back after having it eaten away.

Edited by fluidity, 03 November 2016 - 04:18 AM.

[nicklesprout]

fulvic acid "wu jin san".  one of the best metal chelators as far as i've been told:

 

http://www.wujinsan.us/

 

email dr faust. he will respond to you.

[Oakman]

I'm on the same boat. My mercury amalgam has destroyed my life. I'm not even the same person I once was before it began leaking. It got worse especially after the I removed it which increased the deposition of mercury into my body. I've been dealing with mercury toxicity for 2 years now and I literally feel as though life is passing by without me experiencing it. This infernal poison is sapping years away from my life and this is during a relatively young age for me(early twenties). I'm not going to get these years back which deeply angers me.

 

As a side recommendation be EXTREMELY careful with iodine. It mobilzesmetals but doesn't chelate them out. It raised my symptoms of mercury by 10 fold and I no longer even have the motivation to do anything anymore. My dopamine systems are beyond shot. 

 

I really wish someone can help me here as this is a cry for help. To get my life back after having it eaten away.

 

Some suggestions:  

 

https://www.mercola....ox_protocol.htm

 

https://doctorglen.wordpress.com/msm/

[Oakman]

You've likely been to these, but if not, they may help.

 

https://gadoliniumtoxicity.com/

 

https://gadoliniumto...ation/#more-167

[theCLK]

Yes, I've been able to fully chelate my body and mind from HG+ poisoning. Not a fun affair. I'm not too sure about GAD. That's really tough. ALA is good but you need to use Cutler's protocol. The best substance that exists for Heavy Metal poisoning is BDTH2 or known as OSR#1 in development from Boyd Haley. This stuff is bonkers. Rips the shit right out of you, couldn't recommend it enough.

[fluidity]

Yes, I've been able to fully chelate my body and mind from HG+ poisoning. Not a fun affair. I'm not too sure about GAD. That's really tough. ALA is good but you need to use Cutler's protocol. The best substance that exists for Heavy Metal poisoning is BDTH2 or known as OSR#1 in development from Boyd Haley. This stuff is bonkers. Rips the shit right out of you, couldn't recommend it enough.

 

Can you give us some details on your experience with mercury poisoning? I'm currently dealing with it in full force after removing my amalgam. It also affected me back when I chewed some really tough gum everyday and essentially degraded my amalgam thus causing it to leak. I can't gain weight whatsoever, I have no appetite either, I can't seem to stick things to memory(I remember something in class yet forget it a week later), and libido/ of wellbeing are gone for the most part. 

 

I've tried iodine but it seems to exacerbate the problem. In fact I lost soooo much drive and motivation to do anything including getting out of bed after testing out iodine. Along with that I felt a weird lack of touch with my surroundings, almost like a loss in awareness. 

[theCLK]

It's a long and involved process, what specifically would you like to know? These last few weeks i've been really busy, work in film - 16 hour days. Post your concise questions I'll answer.

[Quaker32]

I've heard that liposomal glutathione (tastes like shit), is good for removing heavy metals from the body. 

[theCLK]

that can work. Very expensive solution and some of the jury is still out how well the body uses synthetic glutathione..

[fluidity]

My concise questions here are-

 

What did mercury poisoning do to you cognition and personality wise? How did you subjectively feel everyday while having it. 

 

My other question is where can I get the same substances you took that aided you in chelation.

 

My only other option I'm looking at right now is taking cilantro given it's amazing ability to remove metals. I'm also going to experiment with resveratrol to see if it does anything for copper since my armpits have had a really bad copper stench ever since last year. 

 

After chelating all of these metals out of me I'll probably start using liver supplements to help fix the damage they have done to it in terms of the lack of appetite and gallbladder like pains I've experienced right around where my biliary ducts were. 

[mrs]

Hello,

 

According to Ramalho in the paper "Gadolinium toxicity and treatment", DTPA seems to be the preferred treatment for gadolinium deposition disease:

 

"Chelation centers generally use ethylenediaminetetraacetic acid (EDTA) as the chelation agent, but EDTA, although showing good thermodynamic stability for smaller atomic number elements, such as calcium, is actually a rather poor chelator for heavier cations such as gadolinium. Probably the best available chelator is pentetic acid diethylenetriaminepentaacetic acid (DTPA), which has good thermodynamic stability and approximately 300,000 times more affinity than EDTA for gadolinium. The worry with EDTA therefore is that it may dislodge gadolinium from tissue stores, but may simply translocate it somewhere else in the body. In contrast, DTPA has the binding strength to not only pick up gadolinium but also retain it long enough to be removed from the body through renal excretion, which is the usual route for GBCA elimination."

 

Attached are the only papers I found that mention gadolinium chelation therapy.

 

Mike

Attached Files

•  Chelation of gadolinium with deferoxamine in a patient with nephrogenic systemic fibrosis.pdf   56.7KB   0 downloads
•  Gadolinium toxicity and treatment.pdf   486.08KB   0 downloads
•  Hepatic Gadolinium Deposition and Reversibility after Contrast Agent-enhanced MR Imaging of Pediatric Hematopoietic Stem Cell Transplant Recipients.pdf   274.37KB   0 downloads
•  Intravenous Ca-Zn-DTPA.pdf   250.1KB   0 downloads

[mrs]

There is a new class of silica based material called SAMMS (self-assembled monolayer on mesoporous supports) that might offer an efficient non-toxic oral method for chelation, the downside is they aren't yet commercially available.

 

Attached are a few studies. There is a company publicizing SH-SAMMS, but I contacted them and its still not available - http://www.pdxpharm.com

 

According to the studies, it would be effective for a number of metals, including cesium lead, mercury, cadium and others, including Gadolinium.

 

Please see studies attached.

 

Attached Files

•  In Vitro and In Vivo Evaluation of a Novel Ferrocyanide Functionalized Nanopourous Silica Decorporation Agent for Cesium (Cs) in Rats.pdf   1.17MB   0 downloads
•  Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion preventive approaches to nephrogenic systemic fibrosis.pdf   386.19KB   0 downloads
•  Novel Oral Detoxification of Mercury, Cadmium, And Lead with Thiol-Modified Nanoporous Silica 2.pdf   337.49KB   0 downloads

Edited by mrs, 14 March 2018 - 10:45 AM.

[mrs]

New study due to be published in Jun/2018 using DTPA as a chelation agent for patients with suspected Gadolinium Deposition Disease (GDD):

 

Intravenous Calcium-/Zinc-Diethylene Triamine Penta-Acetic Acid in Patients With Presumed Gadolinium Deposition Disease - A Preliminary Report on 25 Patients

 

 

The aim of this study was to report the use of intravenous calcium (Ca)-/zinc (Zn)-diethylene triamine penta-acetic acid (DTPA) for the treatment of 25 symptomatic patients diagnosed with gadolinium deposition disease (GDD).

MATERIALS AND METHODS:

Written informed consent was obtained. Twenty-five patients (18 women; mean age, 46.8 ± 15.3 years) with a diagnosis of GDD were included. All patients had received at least 1 administration of a gadolinium (Gd)-based contrast agent. Patients received 3 treatment sessions with Ca-/Zn-DTPA, 15 with treatments spaced 1 month apart, and 10 with treatments spaced 1 week apart. In all cases, every treatment consisted of an application of Ca-DTPA and Zn-DTPA separated by 24 hours. Measurements of 24-hour urine Gd content before dosing and on the first and second days of therapy were performed. Symptomatic improvement of patients was determined by use of a 10-point scale of patient symptoms. Serum electrolytes were quantified.

RESULTS:

Gadolinium content increased in the urine, with an overall mean of 30.3-fold increase in the monthly regimen (P < 0.001) and 12.9-fold in the weekly regimen (P < 0.001). Eleven patients experienced transient worsening of at least some of their symptoms, termed a "flare-up" phenomenon, in most of whom symptoms improved or receded. Overall, symptoms improved in 13 patients, unchanged in 10, and worse in 2. Significant clinical improvement was present for headache, brain fog, and bone pain for the monthly regimen and arm pain and leg pain for the weekly regimen. There were no significant changes in major serum electrolytes.

CONCLUSIONS:

Three courses of intravenous Ca-/Zn-DTPA therapy results in significantly increased urine content of Gd after treatment and moderate symptomatic improvement.

 

Once again they claim the superiority of DTPA over EDTA:

 

 

For this study, all patients were treated with DTPA, which binds Gd several magnitudes more tightly (log Ktherm 17.3 vs 22.1, ie, around 288,000 greater affinity) than EDTA.16,17

 

and

 

 

DTPA is a far superior ligand to chelatewith Gd than EDTA based on its log thermodynamic stability constant (log Ktherm 22.1) compared to EDTA (log Ktherm 17.3).16,17

 

The problem with DTPA is it's difficult to acquire and requires a 4H IV treatment. There is currently no oral form. EDTA has sublingual, IV and suppository forms.

 

 Intravenous Calcium-Zinc-Diethylene Triamine Penta-Acetic Acid in Patients With Presumed Gadolinium Deposition Disease.pdf   250.1KB   0 downloads

[mrs]

Attached below is the 'Chelate Table of Stability Constants' from Dojindo, used in the above study. Very interesting.

 

 

Attached Files

•  Chelate_Table_of_Stability_Constants.pdf   41.17KB   7 downloads