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Abstract
Summary: Although single-nucleotide somatic mutations in the proximal promoter of the human telomerase
reverse transcriptase (TERT) gene create novel consensus sequences for transcription factors that enhance
TERT expression, the precise mechanism of how telomerase is reactivated in cancer cells remains poorly understood.
In this issue, Akıncılar and colleagues identify a potential mechanism of TERT reactivation that is mediated by
a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region.
This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters.
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http://cancerdiscove...ract#abstract-1
