14 replies to this topic

[matisvijs]

I originally got interested in vitamin E due to Ray Peat’ s writings on its anti-estrogenic effects. One of the things that jumped out while researching this vitamin, was the slew of studies and evidence about its liver protective effects. I suggest anyone with liver problems (elevated enzymes, NAFLD etc.) or anyone wanting to protect their liver prophylactically (or using something liver toxic) look into it. Here’ s some of the evidence I was talking about:

 

https://www.ncbi.nlm...pubmed/20427778 – shows a significant reduction in biomarkers of NAFLD (Non-alcoholic fatty liver disease):

‘Vitamin E therapy, as compared with placebo, was associated with a significantly higher rate of improvement in nonalcoholic steatohepatitis (43% vs. 19%, P=0.001)...’

‘...both agents were associated with reductions in hepatic steatosis (P=0.005 for vitamin E and P<0.001 for pioglitazone) and lobular inflammation...’

‘Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes...’

The study used a dose of 800 IU daily for almost 2 years.

 

https://www.ncbi.nlm.nih.gov/pubmed/23933938 - researchers expect that a treatment with vitamin E for more than 2 years can ameliorate non-alcoholic steatohepatitis (cure/improve liver inflammation and damge caused by a buildup of fat in the liver):

 

‘...transaminase activities, insulin resistance index, and hepatic fibrosis markers were significantly improved.’ ‘...liver fibrosis improved in seven patients...’ The study used a dose of 300 IU/day of vitamin E long term (2 years). Serum enzymes (ALT) and biomarkers of fibrosis improved.

 

 

http://www.sciencedi...386634604000403 - reduced liver enzymes by 53% (ALT) alongside a reduction in serum lipid peroxidation. Used 300 mg of vitamin E.

ALT – Alanine Aminotransferase is an enzyme found in the liver. ALT is measured to see if the liver is damaged or diseased. Low levels of ALT are normally found in the blood. But when the liver is damaged or diseased, it releases ALT into the bloodstream, which makes ALT levels go up. Most increases in ALT levels are caused by liver damage.

 

 

https://www.ncbi.nlm...pubmed/11564008 - decreased circulating ALT levels, reduced fibrosis and inflammation of the liver, with the addition of 300 mg vitamin E daily. From the study:

 

‘...Some cases of non-alcoholic steatohepatitis progress to cirrhosis’

'Transforming growth factor-beta1 is implicated in the development of liver fibrosis, and is inhibited by alpha-tocopherol (vitamin E) in the liver.’

‘The serum alanine transaminase level decreased in non-alcoholic fatty liver patients...’

‘The histological findings, such as steatosis, inflammation and fibrosis, of the non-alcoholic steatohepatitis patients were improved after alpha-tocopherol treatment...’ ‘The plasma transforming growth factor-beta1 level in non-alcoholic steatohepatitis patients was significantly elevated compared with that in non-alcoholic fatty liver patients and healthy controls, and decreased, accompanied by an improvement in serum alanine transaminase level, with alpha-tocopherol treatment...’

‘Long-term alpha-tocopherol treatment may be safe and effective for non-alcoholic steatohepatitis.’

 

TGF beta 1 - plasma transforming growth factor-beta1, here’s a wikipedia article on it: https://en.wikipedia...wiki/TGF_beta_1  

 

Dosage: As you can see most studies used a range of 400IU-800IU of vitamin E daily. For prophylactic use I would wager that even 100-200 IUs/day or 400 IUs every 2-3 days would be enough to achieve the protective action of vitamin E on the liver.

 

Recommended brands/buying sources (always use mixed tocopherols):

http://amzn.to/2iNwZW4

http://amzn.to/2iNsElT

http://amzn.to/2iNwDig

 

Here is Dr. Wilfrid E. Shute's updated book  (whom Ray Peat has mentioned in his articles),who’s a legend when it comes to reaserching this vitamin:

http://amzn.to/2iNA3l7

 

 

 

 

 

 

 

Edited by matisvijs, 01 January 2017 - 05:17 PM.

[pamojja]

 

Recommended brands/buying sources (always use mixed tocopherols):

http://amzn.to/2iNwZW4

http://amzn.to/2iNsElT

http://amzn.to/2iNwDig

 

Sorry, but all the products you linked too don't specify the amount of actual gamma-, beta- and delta-tocopherols. Hiding essential ingredients facts, it can be safely assumed they contain minute amount of the other tocopherols added only to justify calling it 'mixed tocopherols'. But the bulk basically the same as regular cheap alpha tocopherol.

 

Never buy products which don't exactly disclose their ingredients. You wont get what you thought.

[matisvijs]

 

 

Recommended brands/buying sources (always use mixed tocopherols):

http://amzn.to/2iNwZW4

http://amzn.to/2iNsElT

http://amzn.to/2iNwDig

 

Sorry, but all the products you linked too don't specify the amount of actual gamma-, beta- and delta-tocopherols. Hiding essential ingredients facts, it can be safely assumed they contain minute amount of the other tocopherols added only to justify calling it 'mixed tocopherols'. But the bulk basically the same as regular cheap alpha tocopherol.

 

Never buy products which don't exactly disclose their ingredients. You wont get what you thought.

 

Well, the products are from some of the most reputable companies in the business. Are there any brands that actually disclose that? If you could post/link some, that'd be helpful then.

[pamojja]

http://www.iherb.com...20-Softgels/205

http://www.iherb.com...-Softgels/71779

http://www.iherb.com...20-Softgels/299

http://www.iherb.com...0-Softgels/8294

http://www.iherb.com...0-Gelcaps/18430

http://www.iherb.com...-Softgels/15880

 

and countless others.

[matisvijs]

http://www.iherb.com...20-Softgels/205

http://www.iherb.com...-Softgels/71779

http://www.iherb.com...20-Softgels/299

http://www.iherb.com...0-Softgels/8294

http://www.iherb.com...0-Gelcaps/18430

http://www.iherb.com...-Softgels/15880

 

and countless others.

Thanks.

[Dorian Grey]

We might also wish to consider Vitamin-E is the most common vitamin deficiency in the standard American diet (and likely elsewhere), with over 90% not getting recommended amounts without supplementation.  

 

 

 

Attached Files

•  Vitamin-E Most Common Deficiency.pdf   200.13KB   10 downloads

[sthira]

Why not instead of supplements just eat more sunflower seeds, almonds, spinach and chard?

[pamojja]

Why not instead of supplements just eat more sunflower seeds, almonds, spinach and chard?

 

Think the aim of this thread is the dosing of a vitamin for pharmacological effects, and not just avoidance of deficiency. In that case it's advisable to eat more of those, along with supplementation.

[joelcairo]

Everyone says to use mixed tocopherols, but what is the actual basis for this? Almost all the experimental studies I have seen on "vitamin E" have used alpha tocopherol alone.

 

Personally I'm a lot more impressed by the effects of tocotrienols in general than tocopherols. Here's a review of clinical studies that seems to suggests that tocotrienols are at least as healthful if not moreso, but comes down on the side of taking both.

http://www.nutraceut..._disease/114312

Edited by joelcairo, 01 January 2017 - 06:59 PM.

[pamojja]

Everyone says to use mixed tocopherols, but what is the actual basis for this? Almost all the experimental studies I have seen on "vitamin E" have used alpha tocopherol alone.

 

Alpha tocopherol, when taken alone at supplemental and higher doses than available from food, depletes serum levels of the other tocopherols.

 

A lot of info on aor's product page. Take a look under Reseach tab, and then under Research and References and Abstract sliders:

 

http://www.aor.ca/en/product/total-e

 

Personally I'm a lot more impressed by the effects of tocotrienols in general than tocopherols. Here's a review of clinical studies that seems to suggests that tocotrienols are at least as healthful if not moreso, but comes down on the side of taking both.

 

Totally agree. And best to take them separate, one with morning meal, the other with the next meal. Or alternate alpha with gammas each other day.

[Dorian Grey]

Everyone says to use mixed tocopherols, but what is the actual basis for this? Almost all the experimental studies I have seen on "vitamin E" have used alpha tocopherol alone.

 

Personally I'm a lot more impressed by the effects of tocotrienols in general than tocopherols. Here's a review of clinical studies that seems to suggests that tocotrienols are at least as healthful if not moreso, but comes down on the side of taking both.

http://www.nutraceut..._disease/114312

 

I've tried "High Gamma" E and found it seemed to give me a foul taste / sour stomach.  I do take E with mixed toco's, but as mentioned above, mine probably doesn't contain much of the non-alpha toco's.  

 

Jarrow "Toco-Sorb" has low dose alpha-E (19 IU) with mixed tocotrienols (57mg) you might be interested in.  

[joelcairo]

Personally I take something called DeltaGold, which is available from a few different manufacturers, as I am mainly interested in delta-tocotrienol and gamma-tocotrienol, and not the other forms or any tocopherols. I'm not claiming it's the best, but for my purposes and based on the research I have seen that's what I have settled on.

[Dorian Grey]

Why not instead of supplements just eat more sunflower seeds, almonds, spinach and chard?

 

Sunflower seed oil is highly polyunsaturated, which I wish to avoid due to oxidation issues.  I manage a few almonds a month, but spinach and chard haven't crossed my lips in the last half century and aren't likely to in the future.  

 

Most all essential nutrients can be obtained through dietary means...  Problem is, most folks don't eat an optimal and adequately varied diet regularly.  I'm a meat & potatoes guy most of the time so supplementation is essential for me.  

Edited by synesthesia, 01 January 2017 - 08:01 PM.

[matisvijs]

 

Why not instead of supplements just eat more sunflower seeds, almonds, spinach and chard?

 

Sunflower seed oil is highly polyunsaturated, which I wish to avoid due to oxidation issues.  I manage a few almonds a month, but spinach and chard haven't crossed my lips in the last half century and aren't likely to in the future.  

 

Most all essential nutrients can be obtained through dietary means...  Problem is, most folks don't eat an optimal and adequately varied diet regularly.  I'm a meat & potatoes guy most of the time so supplementation is essential for me.  

 

Yes, most of the food sources of vitamin E are either very high in PUFA or estrogenic, as far as I've seen (though the opinions on whether that's good or bad vary).

[Kalliste]

2-3 paranuts per day.

(brazil nut)

Edited by Cosmicalstorm, 29 January 2017 - 08:05 PM.