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Crunching the numbers: Researchers use math in search for diabetes cure

research for a cure for type 2 diabetes pancreatic beta cells

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#1 alc

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Posted 01 January 2017 - 06:57 PM


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Bertram’s math equations can simulate many potential biological responses. Researchers test those predictions in an experimental lab with a glass microfluidic device — beautiful in the simplicity of its outer appearance but also daunting in the complexity of its inner design.

 

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With Roper’s microfluidic device, researchers delivered tiny doses of glucose — about one microliter or 1/1000th of a raindrop — to the dormant pancreatic beta cells of mice. When those controlled doses were administered in rhythmic pulses of exactly the right size and frequency, mimicking a healthy body, they triggered inherent oscillators in the islet cells. That caused the cells to vibrate and secrete insulin in a “healthy” fashion.

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http://artsandscienc...h-diabetes-cure

 

http://journals.plos...al.pcbi.1005143

 

http://journals.plos...&type=printable






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