If you recall, the LEF Super Booster (that you have to take along with the LEF Mix in order to avoid the undesirable displacement of other forms of vitamin E by alpha-tocopherol) used to contain tocotrienols. Recently, they replaced the tocotrienols with sesame lignans, reasoning that sesame seed increased tissue and serum levels of gamma and alpha tocopherol, and gamma tocopherol + sesame lignans suppressed free radicals and inflammation 25% more than gamma tocopherol + tocotrienols.
They won't be happy when they hear this:
Sen CK, Khanna S, Roy S.
Life Sci. 2006 Feb 2; [Epub ahead of print]; PMID: 16458936
Abstract:
In nature, eight substances have been found to have vitamin E
activity: alpha-, beta-, gamma- and delta-tocopherol; and alpha-,
beta-, gamma- and delta-tocotrienol. Yet, of all papers on vitamin E
listed in PubMed less than 1% relate to tocotrienols. The abundance of
alpha-tocopherol in the human body and the comparable efficiency of
all vitamin E molecules as antioxidants, led biologists to neglect the
non-tocopherol vitamin E molecules as topics for basic and clinical
research. Recent developments warrant a serious reconsideration of
this conventional wisdom. Tocotrienols possess powerful
neuroprotective, anti-cancer and cholesterol lowering properties that
are often not exhibited by tocopherols. Current developments in
vitamin E research clearly indicate that members of the vitamin E
family are not redundant with respect to their biological
functions. alpha-Tocotrienol, gamma-tocopherol, and delta-tocotrienol
have emerged as vitamin E molecules with functions in health and
disease that are clearly distinct from that of alpha-tocopherol. At
nanomolar concentration, alpha-tocotrienol, not alpha-tocopherol,
prevents neurodegeneration. On a concentration basis, this finding
represents the most potent of all biological functions exhibited by
any natural vitamin E molecule. An expanding body of evidence support
that members of the vitamin E family are functionally unique. In
recognition of this fact, title claims in manuscripts should be
limited to the specific form of vitamin E studied. For example,
evidence for toxicity of a specific form of tocopherol in excess may
not be used to conclude that high-dosage "vitamin E" supplementation
may increase all-cause mortality. Such conclusion incorrectly implies
that tocotrienols are toxic as well under conditions where
tocotrienols were not even considered. The current state of knowledge
warrants strategic investment into the lesser known forms of vitamin
E. This will enable prudent selection of the appropriate vitamin E
molecule for studies addressing a specific need.
AOR wins this round.
