10 replies to this topic

[britefella]

Hello.

I am very newish to this area and have almost confused myself in all the learning and research on nootropics. I am also not sure if I am posting in the appropriate place, so sorry if I offend anyone.

I am considering the following mix of supplements and am wanting some feedback on the synergy and dosages please..

My aim is clarity, alertness and creativity - I am a techer by profession and am reputed to already have an extremely good and retentive short and long term memory. However, lately I find I'm slipping a bit.

(I am 41, 200lbs, very healthy and intelligent, excellent diet.)

(I have tinnitus so vinpocetine and ginko are for a dual reason)

PROPOSED:

Aniracetam
Vinpocetine
Huperzine A / Ginko
Centrophenoxine


ALREADY TAKING:

ALCAR
R-ALA
Green tea extract
Omega 3

Thank you in advance.

[gcurrie]

I suggest that you start with one, try for a few weeks, add another, rinse and repeat.

Try starting with vinpocetine. I also have slight tinnitus (low tone rather than high pitched) and vinpocetine seems to keep it under control. Vinpocetine is a selective cerebral vasodilator so it will increase blood flow and oxygen to any parts of the brain that need it. Be aware that you may experience a little light-headedness at first.

Huperzine is something that I never notice the effects on, but I notice it when I stop - my recall becomes a little more strenuous.

The reason to add one at a time is that nootropics can be exceedingly subtle. So much so that it is all to easy to overdo it, and not notice until others ask you why you've gotten so irritable (for example). You want to be able to notice the change in each new addition, and decide whether it is worth continuing. Depending on your particular neurochemical makeup, some things may be better than others.

If you've never tried a racetam, I would recommend piracetam instead. Why? It's much more widely available, it's cheaper, and it seems to work for many people. If it doesn't do it for you, THEN try aniracetam. (I actually take both. Many people swear by one or the other.)

For your stated goals:

vinpocetine and huperzine could help in clarity and recall
a racetam could help for overall verbal acuity, creativity and awareness

others I might recommend (only after you investigate the ones above) are pyritinol and hydergine.

Also, if you get into racetams, you might need to supplement choline. Best forms are Alpha-GPC or CDP-choline. I've heard that centrophenoxine can supply this, but I don't know if that's true. Maybe someone can confirm or deny this.

[tradewinds]

britefella,

It is easy to become overwhelmed taking in all the information from these boards. Seeing you stack I can tell you know enough already to start experimenting, dont overwhelm yourself with too much more info right now. Add one substance at a time and guage the effects. Do not rush, let it happen in good time so that your final stack is the most effective it can possibly be.

IMO Centrophenoxine Aniracetam would be the best to start with out of those for your situation (because they seem to elicit a more pronounced effect), but I believe gcurrie is more experienced than myself, so heed his advice as well.

[Matt]

I noticed that vinpocetine really works, helps you keep concentration. At first it might feel a bit weird, especially about 30 minutes after taking it! I get this head rush or weird type feeling, quickly passes in about 5 minutes and goes away after a short while when taking it everyday.

Vinpocetine actually made me have tinnitus every day... but would last for a very short time and go away. stopped taking vinpo and this went away !

weird?

[mitkat]

Piracetam is a great place to start also. It's inexpensive, very safe, and can hold potent results. You might need a choline source, like said above. I take centro also and find it gives some good results as far as focus goes.

[rhakshasa]

I'm curious, is it possible to get piracatem "offline" in canada? Because I don't have a credit card...

[britefella]

Thank you all for your input, it is appreciated a lot.

One clarification and one more question, please.

I know you need a choline source to run with the racetams, does centro provide an adequate enough source?

Also - what is the more potent for 'anti-aging' - deprynl, idebenone, centro, others?? From what I have read, deprenyl seems to be the one:

(James South MA)
4 series of rat experiments, as well as an experiment with beagle dogs, have shown that deprenyl can extend lifespan significantly, even beyond the “technical lifespan” of a species. Knoll reported that 132 Wistar-Logan rats were treated from the end of their second year of life with either saline injections or 0.25 mg/kg deprenyl injection 3 times weekly until death. (11)

In the saline-treated group the oldest rat reached 164 weeks of age, and the average lifespan of the group was 147 weeks. In the deprenyl group, the average lifespan was 192 weeks, with the shortest-living rat dying at 171 weeks, and the longest-lived rat reaching 226 weeks.

In a second series of experiments Knoll treated a group of 94 “low-performing” (LP) sexually inactive male rats with either saline or deprenyl injections (0.25 mg/kg) from their eighth month of life until death. (11) Knoll had already established a general correlation between sexual activity status and longevity in the rats. The saline-treated LP rats lived an average 135 weeks, while the deprenyl-treated LP rats averaged 153 weeks of life. The saline treated HP rats lived an average 151 weeks of life, while the deprenyl -treated HP rats averaged 185 weeks of life, with 17/50 HP-deprenyl rats exceeding their estimated technical lifespan of 182 weeks. (20)

Knoll’s experiments were partially replicated by Milgram and co-workers and Kitani and colleagues. (11) Milgram’s group used shorter-living Fischer 344 rats, while still starting deprenyl treatment at 2 years of age - in effect later in their lives - and found a marginally significant 16% lifespan extension. The Kitani group, also using the shorter-lived Fischer rats, started their deprenyl treatment at 1.5 years of age, and found a 34% life increase. (11)



11. Knoll, J. (1995) “Rationale for (-)-deprenyl (selegeline) medication in Parkinson’s disease and in prevention of age-related nigral changes” Biomed Pharmacother 49, 187-95.


Thanks.

[mitkat]

I'm curious, is it possible to get piracatem "offline" in canada? Because I don't have a credit card...

I haven't ever seen it anywhere, and I've scoured Toronto. It's not the kind of thing you can get on the shelves anyways it seems. Where do you live?

[britefella]

I'm in Australia . It's weird, you cannot purchase piracetam in Australia as far as I've seen but you can legally import a 3 month personal supply without any permits at all. A 3 month supply is defined as 90 multiplied by the maximum recommended dosage.
Deprynl and centro are schedule 4 drugs here though.....

EDIT: Oops, just realised you were talking to rhakasha not me - I need those smart drugs pretty soon it seems..........

[rhakshasa]

I'm curious, is it possible to get piracatem "offline" in canada? Because I don't have a credit card...

I haven't ever seen it anywhere, and I've scoured Toronto. It's not the kind of thing you can get on the shelves anyways it seems. Where do you live?

I live near to Quebec city (in quebec ) and I haven't seen it either, damn sucks I can't get a credit card!

[mitkat]

Okay, check your PM, we're getting off topic