5 replies to this topic

[bigt]

Hi people, I've been on this site for a long time and found the information excellent, now I'm going to ask a couple of questions and see if you guys can helpout. My brother in law has just been diagnosed with a very serious Butterfly Glioma on the brain, I've been doing some digging around and found some really good papers on the effect of RES on tumours, such as: Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway (Yuan Yuan,1,2 Xue Xue, Ruo-Bing Guo, Xiu-Lan Sun & Gang Hu1). Personally I've been taking RES for about 20 years so I've suggested that he also takes it, alongside a full ketogenic  diet, interestingly his Oncologist agrees and says that it is one of the most promising non pharmaceutical supplements he has come across. Now for my first question, have any of you had actual experience including dosage levels for this form of supplementation?

 

My second question is a little bit concerning because I’m not sure if somebody is trolling or trying some misinformation, I’ve been getting my RES from two main sources, RevGenetics, and though the web site is a pain and has recently not allowed me to get an order delivered to the UK for some reason, I do trust them. The second source has been I-Herb and Genceutic Naturals, pTeroBlue, Pterostilbene + Resveratrol, 350 mg, 60 V-Caps. These have always appeared to have been fine but I've never actually had them analysed, now on the I-Herb review part of the website comes this:-

 

Fake products just rice flour with some dried berries. Not recomended. regreted to buy

Posted by 5573606424698072913 on Sep 09, 2016 | Verified Purchase

fake products just rice flour with some dried berries. Not recomended to buy. I had tested it. Mainly contain rice flour. Hope iherbs more strict on this.

 

Can anybody shed any light on this?

 

[maxwatt]

Short of testing the product, I don't know of a way to tell.  I've not heard of pteroblue, that's neither plus or minus. 

 

As for resveratrol dosing, pharmokinetic studies  have shown a linear dose to blood level relationship up to doses of one gram.  Beyond that, less is absorbed but you are probably increasing blood levels with up to 4 or 5 gram doses. Doses that high produce diarrhea in many people.  Rather than a two gram dose, one might do better with two one gram doses. 8 to 12 hours apart. 

 

My guess is one should take the highest dose one can tolerate, and if there is any sign of intestinal distress, cut back. 

 

Individuals I've known who had lung cancer did not benefit from resveratrol.  A dog with liver cancer that had metastasized apparently recovered,  and lived another two years though he was expected to live for 3 month at most.  His owner put him down when his legs stopped working and she could no longer carry the 135 pound dog up to her 3rd floor apartment.  The dosage was a teaspoon mixed with salmon or other dog food.  The owner did not measure precisely.

 

I hope your brother does well.

[RWhigham]

Google  "Andrographis for glioblastoma". There are several articles such as:

 

Adjunctive Botanical Therapy for Glioblastoma  Clinical cases for several adjunctive supplements including Andrographis

 

Andrographolide Induces Apoptosis of C6 Glioma Cells via the ERK-p53-Caspase 7-PARP Pathway

 

Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression

 

Edited by RWhigham, 02 December 2017 - 04:25 AM.

[RWhigham]

The majority of herbs modify different detox family enzymes (CYP's) making them stronger.or weaker. For example, grapefruit juice is a well known inhibitor of various CYP's.

 

Concurrently taking a medicine and herb that share CYP's can cause the medicine to be eliminated faster (reducing efficacy) or slower (increasing side effects and toxicity).. A narrow therapeutic window (typical of chemo) could be wreaked.

 

The herb and medicine would not conflict if they use different CYP's but this may be difficult to ascertain.

Edited by RWhigham, 02 December 2017 - 07:15 PM.

[bigt]

Many thanks for that, the papers make interesting reading, any idea of where to get andrographolide?

 

Unfortunately the prognosis is not good, he has had surgery, to remove as much of the tumour as possible, followed by radio and chemo therapy. Interestingly enough his consultant agreed that Resveratrol was a good choice and he has been taking that together with a medicinal form of cannabis, this has appeared to slow the tumour growth. It is fighting back, by causing fluid retention and saline imbalance,

 

I'll let you know what happens.

[RWhigham]

 

 

 any idea of where to get andrographolide?

 

It's readily available at Amazon . Make sure you pick a standardized extract like for example "Now" Andrographis which is standardized to 10% andrographolide in a 400 mg capsule (giving 40 mg of andrographolide). Avoid "full spectrum" products which are the raw herb, not a concentrated extract.