31 replies to this topic

[dogbarf]

I know there's been a thread on centro before, but I was wondering specifically if anyone has experience with both, and whether or not there was a noticeable difference. I'm a student on a budget, and the difference in price is significant. I'm a big fan of DMAE and take it with piracetam. Has anyone switched to centro from DMAE, and why was it worth it?

[LifeMirage]

I know there's been a thread on centro before, but I was wondering specifically if anyone has experience with both, and whether or not there was a noticeable difference. I'm a student on a budget, and the difference in price is significant. I'm a big fan of DMAE and take it with piracetam. Has anyone switched to centro from DMAE, and why was it worth it?

Centrophenoxine is quite more potent than DMAE, both as a nootropic and an antiaging compound....if cost is an issue buying it in bulk form should not be remarkably more expensive. But you would have to try it to see if it gives you the effects you are looking for. For some the more potent ACh precursors such as Alpha GPC or CDP-Choline are the most effective when taken with Piracetam.

[dogbarf]

I was under the impression that dmae was a choline precursor, and that recent studies show that it may even be (slightly) anticholinergic?

[LifeMirage]

I was under the impression that dmae was a choline precursor, and that recent studies show that it may even be (slightly) anticholinergic?

DMAE (DiMethylAminoEthanol) can easily be converted into choline (also know as TriMethylAminoEthanol) by methylation and is converted into PhosphatidylAminoEthanol when incorporated into cellular membranes.

As far as Centrophenoxine the answer is alittle complex as it has several effects on ACh levels, receptor activity, etc…

Neuropharmacology. 1982 Apr;21(4):349-54.

"Meclofenoxate, the p-cholorophenoxyacetic acid ester of deanol, was found to dramatically elevate choline (Ch) levels…..

In summary, meclofenoxate induced dramatic alterations in CNS choline metabolism and may, therefore, be a useful therapeutic tool for potentiating depressed cholinergic neurons."

[syr_]

Centrophenoxine is quite more potent than DMAE, both as a nootropic and an antiaging compound....if cost is an issue buying it in bulk form should not be remarkably more expensive. But you would have to try it to see if it gives you the effects you are looking for. For some the more potent ACh precursors such as Alpha GPC or CDP-Choline are the most effective when taken with Piracetam.

If my goal would be only preserving skin elasticity, would still Centrophenoxine use preferred to DMAE?

[LifeMirage]

Yes.

[syr_]

Thank you
Gotta find it now...

[mitkat]

If my goal would be only preserving skin elasticity, would still Centrophenoxine use preferred to DMAE?

Little know fact: that is one of the major reasons I started taking centro. As stated in the imminst chat, I'm a vain mofo [wis]

Are you also using moisturizer? Duke was talking about a master moisturizer he has made from 5 different lotions, adding in green tea max, etc...pretty awesome stuff.

[johnmk]

Is there supposed to be an acute beneficial effect as well on skin elasticity, or is it only preserving what you've got?

[mitkat]

I think it's supposed to give an acute benefit, in removing the lipofuscin in skin cells, but of course, I don't remember where i read that. Johnmk...you GOONIE!

[syr_]

If my goal would be only preserving skin elasticity, would still Centrophenoxine use preferred to DMAE?

Little know fact: that is one of the major reasons I started taking centro. As stated in the imminst chat, I'm a vain mofo [wis]

Are you also using moisturizer? Duke was talking about a master moisturizer he has made from 5 different lotions, adding in green tea max, etc...pretty awesome stuff.

Yeah, I use nivea moisturizing cream with vit. E about 4 times a week, on my arms (i have mixed skin, mostly dry). I find it pretty good but the smell is not too neutral.
I also tried a dry oil, used after shower but didnt like it (particularly for the perfume).

I'm not up to homemade a DYI, but I'm surely interested to know more of what Duke made
The smell is very important, I gave up on a pretty good moisturizer for the perfume (again) that I didnt like in it.

In general I prefer to improve the appearance working from the inside (vitamins, anti-ox, collagen release stimulators etc).
I believe that most of this stuff does NOT work topically and that most creams are a big waste of money. Collagen/HA for istance, DMAE may work good topically.

I'm interested in discussing skin antiaging futher (maybe a new topic, we are hijacking this thread a bit).

[syr_]

OK, I'm bumping this because I cant find centrophenoxine in bulk powder in Europe (its a Rx drug in most countries :( ), while I could easily get DMAE.

I would like other opinions on this, and I'm interested ONLY on the anti-aging effect on the skin (elasticity and lipofuscin removal).

[jackinbox]

For skin elasticity, do you have to use DMAE topicaly or oraly?

[syr_]

It would work orally too (like centro) and that was the route I'm thinking.

[fntms]

OK, I'm bumping this because I cant find centrophenoxine in bulk powder in Europe (its a Rx drug in most countries :( ), while I could easily get DMAE.

I would like other opinions on this, and I'm interested ONLY on the anti-aging effect on the skin (elasticity and lipofuscin removal).

Where would you get bulk DMAE in Europe? I'd be interested. Thanks.

[impulsive]

If my goal would be only preserving skin elasticity, would still Centrophenoxine use preferred to DMAE?

Little know fact: that is one of the major reasons I started taking centro. As stated in the imminst chat, I'm a vain mofo [wis]

Are you also using moisturizer? Duke was talking about a master moisturizer he has made from 5 different lotions, adding in green tea max, etc...pretty awesome stuff.

anymore info on this?

I have extremley dry skin... I have to use aveeno moisturizer on my body, and only nivea on my face (other wise i break out)

really sucks being a male, and saying, "I need cream on my face!" haha

although in the end, my face has no acne, and very very smooth, ladies love it [thumb]

[dogbarf]

Just an ironic note, since this post was rehashed; Despite abandoning that "budget" almost a year ago and completely overspending on nootropics, I've yet to try Centro, let alone replace my almost-gallon container of DMAE.

[cellfighter]

I take cheap bulk centrophenoxine. Tastes disgusting!!!

[syr_]

DMAE just tastes bitter. I have a lot to use, then maybe i'll switch to centro.

[xanadu]

I found centro to be too stimulating. I use dmae and it seems to do the job. It's a very noticeable difference between using piracetam with no choline source and using 250mg of dmae per day. Just cap it up, invest in a capping machine kit. There are some good threads on capping, do a search.

[parsons]

If my goal would be only preserving skin elasticity, would still Centrophenoxine use preferred to DMAE?

Little know fact: that is one of the major reasons I started taking centro. As stated in the imminst chat, I'm a vain mofo [wis]

Are you also using moisturizer? Duke was talking about a master moisturizer he has made from 5 different lotions, adding in green tea max, etc...pretty awesome stuff.

dug this thread up when doing research on centrophenoxine.  I didn't realize that centro can help with skin elasticity.  I knew it can remove lipufuscin but that also effects skin elasticity or is there another mechanism?  Any studies or links regarding centro and skin elasticity?

[kilgoretrout]

I found centro to be too stimulating. I use dmae and it seems to do the job. It's a very noticeable difference between using piracetam with no choline source and using 250mg of dmae per day. Just cap it up, invest in a capping machine kit. There are some good threads on capping, do a search.

I had been using Piracetam but after about a month it started making feel actually dopey or sleepy, and I was starting to have balance/dizziness problems that it seems to cause in some.

So I added 100mg daily of DMAE-H3 (Twinlab... though I bet plain old DMAE in capsules would work the same).

And I can CONFIRM! the above. Almost instantly, within hours, the dizziness and drowsyness were reduced by about 85%... and after a week now of adding the DMAE the combination is GREAT, just amazingly GREAT! BOTH those side effects are 100% gone. Thank goodness.

While the Piracetam (nor the DMAE) by itself did not seem to do much for my diagnosed (but only briefly treated a few years ago) "Adult ADD"... the combination of Piracetam and DMAE-H3 seems to be doing something very very good.

Finally!

[HarPe]

I found centro to be too stimulating. I use dmae and it seems to do the job. It's a very noticeable difference between using piracetam with no choline source and using 250mg of dmae per day. Just cap it up, invest in a capping machine kit. There are some good threads on capping, do a search.

Centro is essentially DMAE+Niacin, correct? Is it different in functionality from combining Niacin and DMAE? If so, how?

I've heard DMAE raises blood Choline levels, but that it also inhibits the conversion to ACh or something like that... If this is true, i wonder where the effect of Centro comes from. From the Niacin?

[Imagination]

I found centro to be too stimulating. I use dmae and it seems to do the job. It's a very noticeable difference between using piracetam with no choline source and using 250mg of dmae per day. Just cap it up, invest in a capping machine kit. There are some good threads on capping, do a search.

I had been using Piracetam but after about a month it started making feel actually dopey or sleepy, and I was starting to have balance/dizziness problems that it seems to cause in some.

So I added 100mg daily of DMAE-H3 (Twinlab... though I bet plain old DMAE in capsules would work the same).

And I can CONFIRM! the above. Almost instantly, within hours, the dizziness and drowsyness were reduced by about 85%... and after a week now of adding the DMAE the combination is GREAT, just amazingly GREAT! BOTH those side effects are 100% gone. Thank goodness.

While the Piracetam (nor the DMAE) by itself did not seem to do much for my diagnosed (but only briefly treated a few years ago) "Adult ADD"... the combination of Piracetam and DMAE-H3 seems to be doing something very very good.

Finally!

Have you tried the DMAE without the piracetam? It's probably just the DMAE thats working I think.

[nito]

if anyone's got two credible, safe and quality source to where you can buy dmae and centro then please share. I have tried CDP , but would like to try these two now.

[HarPe]

Centro is Parachlorophenoxyacetic Acid + DMAE

Ah right, the Niacin was in Picamilon, d'oh...

[nito]

hey does anybody know if you can mix choline with DMAE or are they to be taken separately?

[pycnogenol]

if anyone's got two credible, safe and quality source to where you can buy dmae and centro then please share.

Anyone buy Centro from nutraceuticsrx.com ?

http://www.nutraceut...rophenoxine.htm

Edited by pycnogenol, 09 December 2009 - 04:33 PM.

[en1gma]

hey does anybody know if you can mix choline with DMAE or are they to be taken separately?

I'm interested in learning about this as well. I've been reading about this for awhile now and still can't seem to get a clear answer. Supposedly DMAE can be anti-cholinergic? But yet some people swear by it in terms of supplementing 'racetams?

If it is in fact anti-cholinergic, can mixing it with another choline source give you the benefit of both?

I really hope all of you incredibly knowledgeable folks here at ImmInst can answer this question for us