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resveratrol reactivates HIV

resveratrol hiv

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#1 normalizing

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Posted 11 June 2017 - 06:29 AM


ok this is what i found; http://pubs.acs.org/...cs.jafc.7b00418

 

ok i just found this, i have no access to the full article and i cannot figure out how to get full access but i decided to post this intro regardless since its a new thing and i found it interesting regardless of the little information present so i really have no opinion and understanding of this thus far


Edited by hazy, 11 June 2017 - 06:31 AM.


#2 Supierce

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Posted 11 June 2017 - 12:55 PM

The headline sounds alarming, but I would focus on the conclusion: "Collectively, this research reveals that resveratrol is a natural LRA and shows promise for HIV therapy." Maybe by activating latent HIV, resveratrol brings it out of hiding so that other therapies can eradicate it.


Edited by Supierce, 11 June 2017 - 01:01 PM.


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#3 normalizing

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Posted 11 June 2017 - 06:59 PM

yeah i was confused about it too, but if it really brings HIV from hiding, isnt that a novel thing and gives resveratrol a major role in the disease? it would seem so, but its just a small study nobody talks about



#4 sensei

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Posted 02 January 2018 - 06:07 PM

yeah i was confused about it too, but if it really brings HIV from hiding, isnt that a novel thing and gives resveratrol a major role in the disease? it would seem so, but its just a small study nobody talks about

 

Nope, it's not novel

 

HDAC (histone de-acetylase)  inhibitors for sure reactivate HIV

 

Reactivation of latent HIV by histone deacetylase inhibitors.

 

https://www.ncbi.nlm...pubmed/23517573

 

 

Garlic for one does the same thing

 

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.

https://www.ncbi.nlm...pubmed/19197985



#5 normalizing

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Posted 03 January 2018 - 04:18 AM

so garlic can be bad for people with hiv?



#6 sensei

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Posted 03 January 2018 - 04:21 AM

so garlic can be bad for people with hiv?

 

No -- quite the opposite

 

Activating latent HIV allows for anti-retrovirals to destroy the virus and the infected cell (virus factory) -- it can help in clearing the latent reservoir

 

Latent HIV hides from meds



#7 normalizing

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Posted 04 January 2018 - 03:47 AM

i see. but if you use only things like garlic and resveratrol to bring latent HIV but not use anti-retrovirals to deal with it, that will not be a good thing overall. as in, what does it really do then? those two arent going to destroy any retroviruses by themselves



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#8 sensei

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Posted 04 January 2018 - 02:59 PM

i see. but if you use only things like garlic and resveratrol to bring latent HIV but not use anti-retrovirals to deal with it, that will not be a good thing overall. as in, what does it really do then? those two arent going to destroy any retroviruses by themselves

 

Well,

 

Some sulfur compounds in garlic ARE anti-retroviral with respect to HIV.

 

But,

 

Yes, you would need to take a cocktail of anti-HIV meds -- or a neutralizing antibody (or several) -- to take advantage of the reactivation and empty the reservoir of latent HIV.

 

With CRISPR the spectre of HIV is beginning to fade.

 

Researchers have already completely removed HIV from infected cells using the CRISPR gene editing technique.

 

 

https://www.genengne...nimals/81254287

 

 

http://www.sciencedi...525001617301107






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