There is little evidence except in vitro that rosmarinic acid breaks crosslinks. The in vitro study involved carsonic as well as rosmarinic acid in a 98% pure extraction. You can get a max of 30% from Dynveo, a company owned by one of the members on Longecity. I tried getting the 98% from Sigma Aldrich but they won't sell to me. I wouldn't put too much stake in it breaking glucosepane crosslinks however, as the in vitro study did not reveal the type of AGE they were testing on. If it wasn't glucosepane then it's largely useless and a shot in the dark at best since we just don't know. I've been taking rosmarinic acid off and on a lot with carnosine for the past year or so and honestly, I just don't know. Given what I know about AGEs and the fact that there are multiple pathways in glycation besides ROS and transition metals, we're probably better off breaking than trying to block. Does RA break? According to that study yes in vitro it breaks better than ALT-711 but even then, ALT-711 did not affect glucosepane or even pentosidine to my knowledge. These are two types of AGEs that are tough to break and the most common one is glucosepane.
From what I understand, recently, Yale scientists in the Spiegel lab have successfully synthesized glucosepane in order to find drug candidates that break the crosslinks.
What if they find the crosslink breaker, what then? They'll just reforge if you stop taking the drug, how do you sweep out the AGEs once the crosslinks are broken? Is that possible to do?
Edited by Nate-2004, 02 August 2017 - 08:30 PM.