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Asc2P Vitamin C

asc2p vitamin vitamin c ascorbyl phosphate magnesium phosphorylated ascorbate

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#1 recon

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Posted 01 November 2017 - 10:49 PM


Hi,

 

I was wondering, does anyone have a source for Asc2P, aka phosphorylated ascorbate, aka L-ascorbic acid 2-phosphate magnesium (?), aka magnesium ascorbyl phosphate (?) ?

 

I searched for them but I have only encountered many topical creams. 

 

The only one still available is probably http://www.supersmar...2P-250-mg--0641

 

Apparently, in-vitro studies have shown that it "appreciably reduced the age-related decline in levels of telomerase" and other forms of age-related declines.

 

Thanks in advance!


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#2 Daniel Cooper

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Posted 01 November 2017 - 11:19 PM

Interesting.  Could you possibly post that study?

 

 

 



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#3 recon

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Posted 01 November 2017 - 11:44 PM

Interesting. Could you possibly post that study?

I haven’t look much into them but I believe this is the in-vitro study on telomeres:

Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress.
Yokoo S, et al. J Cell Biochem. 2004.
https://www.ncbi.nlm...ubmed/15378602/

An excerpt from the abstract:
“The cellular life-span of cultivated human skin epidermis keratinocytes NHEK-F was shown to be extended up to 150% of population doubling levels (PDLs) by repetitive addition with two autooxidation-resistant derivatives of ascorbic acid (Asc), Asc-2-O-phosphate (Asc2P), and Asc-2-O-alpha-glucoside (Asc2G), respectively, but to be not extended with Asc itself.”


There’s one more on cancer metastasis as well:

Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress.
Nagao N, et al. J Cancer Res Clin Oncol. 2000
https://www.ncbi.nlm...ubmed/11003563/


I first came across this substance in an old Life Enhancement online magazine from 2001 (http://www.life-enha...es-and-dementia)

Although all of them are in-vitro but I thought that since this is a relatively nontoxic Vitamin C, may as well add it or to replace my current “ordinary” ascorbate.

It’s quite unfortunate that this substance just died and no further studies were conducted.

Edited by recon, 01 November 2017 - 11:45 PM.

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#4 Believer

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Posted 02 November 2017 - 08:55 PM

The chemical is so obscure and lots of things affect telomeres mildy that it wouldn't make sense.

Instead try sodium selenite which is also touted to increase telomerase activity.

https://www.scienced...895398809600611


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#5 Daniel Cooper

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Posted 02 November 2017 - 08:57 PM

The only thing I would worry about with a selenium compound is overdosing.  The advantage I see with Asc2P is that it should be very difficult to overdose.

 

 

 


Edited by Daniel Cooper, 02 November 2017 - 09:00 PM.

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#6 recon

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Posted 04 November 2017 - 12:51 AM

This is a good supplement to look at also because we’re probably taking Vitamin C as well, and Asc2P seems to be one of the “autooxidation-resistant derivatives of ascorbic acid”. Probably better than just M the regular ascorbic acid that may be oxidised easily.
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#7 Believer

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Posted 04 November 2017 - 01:51 AM

I encourage you to try it if you have the money. Would give us new knowledge ;)

Just know that vitamin C with carnitine in higher dosages (I believe it was this combo) to prevent telomere attrition has already been attempted and shown to be completely useless, telomeres were still getting shorter. This was over at the vitamin c foundation's forum, the telomere subforum. I know they are two different vitaminers of vitamin C.



#8 recon

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Posted 04 November 2017 - 04:06 AM

I found another study on this topic:

Life Sci. 1998;63(11):935-48.
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress.
Furumoto K1, Inoue E, Nagao N, Hiyama E, Miwa N.
https://www.ncbi.nlm...pubmed/9747894/

An excerpt -
“Here, we succeeded in artificial slowdown of age-dependent telomere shortening to 52-62% of the untreated control, in human vascular endothelial cells, by addition of the oxidation-resistant type of ascorbic acid (Asc), Asc-2-O-phosphate (Asc2P), which concurrently achieved both extension of cellular life-span and prevention of cell size enlargement indicative of cellular senescence”

#9 recon

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Posted 04 November 2017 - 04:32 AM

I encourage you to try it if you have the money. Would give us new knowledge ;)
Just know that vitamin C with carnitine in higher dosages (I believe it was this combo) to prevent telomere attrition has already been attempted and shown to be completely useless, telomeres were still getting shorter. This was over at the vitamin c foundation's forum, the telomere subforum. I know they are two different vitaminers of vitamin C.

I may!

I’m now looking at two products on the market. There seems to be no other product having Asc2P.

1. Supersmart.com; 250 mg, 60 Veg Caps, $37.30
Other ingredients: microcrystalline cellulose, magnesium stearate, silicon dioxide
http://www.supersmar...2P-250-mg--0641

2. Terraternal; 150 mg, 60 Caps, $56
http://www.terratern...te/617/177.aspx

The second option list neither the type of capsule or the other ingredients. Plus, it’s apparently out of stock until 11/15/2017, and it’s more expensive. Haven’t looked at the shipping fees between them yet though.

Any recommendation between them? Any other products you may find?

#10 zorba990

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Posted 04 November 2017 - 11:18 PM

Magnesium ascorbyl phosphate is readily available in bulk for cosmetic use.
E.g. https://www.makingco...hate_p_323.html

Edited by zorba990, 04 November 2017 - 11:19 PM.


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#11 recon

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Posted 05 November 2017 - 12:28 AM

Magnesium ascorbyl phosphate is readily available in bulk for cosmetic use.
E.g. https://www.makingco...hate_p_323.html

Hi,

Yeah, I’ve been using the topical formulation from Deciem The Ordinary: http://theordinary.c...hate-10pct-30ml

But now I’m looking for an oral consumption to try to benefit from the telomerase activation and the oxidation-resistant Vitamin C.





Also tagged with one or more of these keywords: asc2p, vitamin, vitamin c, ascorbyl, phosphate, magnesium, phosphorylated ascorbate

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